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B-Cell Antigen Receptors (B Cell Antigen Receptors)

Subscribe to New Research on B-Cell Antigen Receptors

IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.

Also Known As:

B Cell Antigen Receptors; Receptors, Antigen, B-Cell; Immunoglobulins, Membrane-Bound; Immunoglobulins, Surface; Membrane Bound Immunoglobulin; Membrane-Bound Immunoglobulins; Receptors, Antigen, B Cell; Surface Immunoglobulins; Antigen Receptors, B Cell; Bound Immunoglobulin, Membrane; Immunoglobulin, Membrane Bound; Immunoglobulins, Membrane Bound; Membrane Bound Immunoglobulins; Receptors, B-Cell Antigen; Antigen Receptors, B-Cell

Networked: 162 relevant articles (1 outcomes, 7 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489

Experts

1.	Chapman-Fredricks, J R: 1 article (07/2015)
2.	Hsu, D K: 1 article (07/2015)
3.	Alvarez Cubela, S: 1 article (07/2015)
4.	Kunkalla, K: 1 article (07/2015)
5.	Lossos, I S: 1 article (07/2015)
6.	Zhu, D: 1 article (07/2015)
7.	Liu, F-T: 1 article (07/2015)
8.	Bhatt, S: 1 article (07/2015)
9.	Vega, F: 1 article (07/2015)
10.	Veelken, H: 1 article (07/2015)

Related Diseases

1.	Hereditary Spherocytosis 09/15/2002 - "Red cell (RBC) deformability and membrane-bound immunoglobulin G (IgG) were studied to better understand premature clearance of erythrocytes in hereditary spherocytosis. "
2.	Lymphoma (Lymphomas) 02/01/1975 - "An immuno-ultrastructural study of surface immunoglobulins in metastasizing and non-metastasizing hamster lymphomas." 08/01/2002 - "Immunohistochemistry revealed neither lymphoma markers nor clonal cytoplasmic nor cell surface immunoglobulins. " 02/01/1993 - "The lymphoma cells expressed monoclonal surface immunoglobulins with moderate to strong intensity in all 7 of the patients diagnosed as leukemic. " 12/01/1990 - "All lymphomas tested were negative for thy-1.2, and five of them expressed surface immunoglobulins. " 01/01/1986 - "The technique did not reveal any surface immunoglobulins in two cases of malignant lymphomas of Burkitt type. "
3.	Neoplasms (Cancer) 01/01/1991 - "Our study confirms other published data on V gene expression in B-CLL in that the surface immunoglobulins in these tumors are unmutated." 07/01/2015 - "OAEMZLs are monoclonal tumors expressing a biased repertoire of mutated surface immunoglobulins. " 03/01/2003 - "Remarkably, pooled cells rapidly re-expressed Pax5 and formed tumors of relatively mature lymphoid phenotype, with surface immunoglobulins being abundantly expressed. " 07/01/1992 - "JH (on both primary tumor and the cell line) and C kappa were rearranged without expression of cytoplasmic or surface immunoglobulins. " 10/15/1989 - "The surface immunoglobulins and the HLA type of these tumor cells were identical with those of the parental cells. "
4.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 04/01/2004 - "Studies of B cell antigen receptors (BCRs) expressed by leukemic lymphocytes from patients with B cell chronic lymphocytic leukemia (B-CLL) suggest that B lymphocytes with some level of BCR structural restriction become transformed. " 01/01/1985 - "Characterization of chronic lymphocytic leukemia (CLL) cells with low density of surface membrane bound immunoglobulins (smIg)." 01/01/1979 - "Results from normal human lymphocytes and cells from cases of Chronic Lymphoblastic Leukemia (CLL) indicate that the method makes it possible to recognize cells with surface immunoglobulins and permits some correlation between the surface architecture of the cells and the presence of surface Ig. " 01/01/1976 - "[Surface immunoglobulins of lymphocytes in chronic lymphocytic leukemia]." 08/01/1973 - "Cell-surface immunoglobulins in chronic lymphocytic leukemia and allied disorders."
5.	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/01/1982 - "Distribution of intercellular, intracytoplasmic and surface immunoglobulins in type B non-Hodgkin lymphoma: employment of indirect immunofluorescence in the detection of immunomorphological features." 05/01/1973 - "Surface immunoglobulins on lymphocytes in chronic lymphocytic leukaemia and lymphosarcoma." 02/01/1974 - "Surface immunoglobulins of lymphocytes in chronic lymphocytic leukemia and disseminated lymphosarcoma." 03/01/1982 - "Tumor cells from a total of 116 children with non-Hodgkin's lymphoma were studied for their pattern of reactivity with a battery of cell markers, including their capacity for spontaneous formation of sheep erythrocyte rosettes (E-rosettes), demonstration of surface immunoglobulins (SIg), and positivity with antisera against T-cell antigens, the common acute-lymphoblastic-leukemia-associated antigen (cALLa), and Ia-like antigens. " 01/01/1977 - "In the present study, 15 children with non-Hodgkin lymphoma have been immunologically evaluated by the following parameters on peripheral blood (PB) lymphocytes: phytohemagglutinin responsiveness (PHA-r); non-immune rosette formation with sheep red blood cells (RF-L) as T-cell marker; presence of surface immunoglobulins (sIg-L) as B-cell marker; serum immunoglobulins levels (IgA, IgM, IgG). "

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	Immunoglobulin A (IgA)
3.	Immunoglobulins (Immunoglobulin)
4.	Immunoglobulin M (IgM)
5.	HLA-DR Antigens (HLA-DR)
6.	Biological Markers (Surrogate Marker)
7.	Peroxidase (Myeloperoxidase)
8.	HLA-B27 Antigen (HLA B27 Antigen)
9.	Antigens
10.	Complement Receptors (Complement Receptor)

Related Therapies and Procedures

1.	Radical Mastectomy
2.	Transplantation (Transplant Recipients)
3.	Combination Drug Therapy (Combination Chemotherapy)