Ranula

A form of retention cyst of the floor of the mouth, usually due to obstruction of the ducts of the submaxillary or sublingual glands, presenting a slowly enlarging painless deep burrowing mucocele of one side of the mouth. It is also called sublingual cyst and sublingual ptyalocele.

Also Known As:

Networked: 66 relevant articles (7 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Lymphangioma (Cavernous Lymphangioma)
2.	Sclerosis
3.	Mucocele
4.	Cysts
5.	Branchioma (Branchial Cleft Cysts)

Experts

1.	Ohta, Nobuo: 3 articles (02/2014 - 03/2003)
2.	Fukase, Shigeru: 3 articles (02/2014 - 03/2003)
3.	Aoyagi, Masaru: 3 articles (02/2014 - 03/2003)
4.	Syebele, Kabunda: 3 articles (07/2013 - 02/2011)
5.	Roh, Jong-Lyel: 3 articles (09/2008 - 09/2004)
6.	Garofalo, Salvatore: 2 articles (04/2014 - 02/2007)
7.	Suteu, Liana: 2 articles (04/2014 - 02/2007)
8.	Suzuki, Yusuke: 2 articles (02/2014 - 11/2010)
9.	Bütow, Kurt-W: 2 articles (06/2011 - 02/2011)
10.	Zola, Malcolm: 2 articles (06/2007 - 05/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ranula:

1.	PicibanilIBA 05/01/2012 - "We report a very rare case of a plunging ranula extending into the parapharyngeal space, which was treated successfully with OK-432. " 02/01/2002 - "Our experience suggests that OK-432 injection is an effective treatment for ranula. " 02/01/2014 - "Our results confirmed that OK-432 therapy is simple, easy, safe, and effective and can be used as a substitute for surgery in the treatment of ranula extending to the parapharyngeal space. " 02/01/2014 - "The aim of this study was to evaluate the outcome and complications of the OK-432 treatment of patients with ranula extending to the parapharyngeal space. " 02/01/2006 - "This study examined the effectiveness of intracystic injection of OK-432 for treatment of ranula. "
2.	NickelIBA 04/01/2014 - "Eighteen patients, including 3 who had relapsed after either simple marsupialization or ranula removal alone, received oral nickel gluconate, mercurius heel, and glandula submandibularis suis D10/D30/D200. " 02/01/2007 - "This preliminary study evaluates the effectiveness of the use of Nickel Gluconate-Mercurius Heel-Potentised Swine Organ Preparations as the primary treatment of pediatric ranula and intraoral mucocele. " 02/01/2007 - "Homotoxicological therapy with Nickel Gluconate-Mercurius Heel-Potentised Swine Organ Preparations D10/D30/D200 is an effective primary treatment of pediatric ranula and intraoral mucocele." 02/01/2007 - "Nickel Gluconate-Mercurius Heel-Potentised Swine Organ Preparations: a new therapeutical approach for the primary treatment of pediatric ranula and intraoral mucocele." 02/01/2007 - "Eighteen children (9 ranulas, 9 labial mucoceles, 2 lingual mucoceles) were treated with oral administration of Nickel Gluconate-Mercurius Heel-Potentised Swine Organ Preparations D10/D30/D200. "
3.	gluconic acid (gluconate)FDA LinkGeneric 04/01/2014 - "Eighteen patients, including 3 who had relapsed after either simple marsupialization or ranula removal alone, received oral nickel gluconate, mercurius heel, and glandula submandibularis suis D10/D30/D200. " 02/01/2007 - "This preliminary study evaluates the effectiveness of the use of Nickel Gluconate-Mercurius Heel-Potentised Swine Organ Preparations as the primary treatment of pediatric ranula and intraoral mucocele. " 02/01/2007 - "Homotoxicological therapy with Nickel Gluconate-Mercurius Heel-Potentised Swine Organ Preparations D10/D30/D200 is an effective primary treatment of pediatric ranula and intraoral mucocele." 02/01/2007 - "Nickel Gluconate-Mercurius Heel-Potentised Swine Organ Preparations: a new therapeutical approach for the primary treatment of pediatric ranula and intraoral mucocele." 02/01/2007 - "Eighteen children (9 ranulas, 9 labial mucoceles, 2 lingual mucoceles) were treated with oral administration of Nickel Gluconate-Mercurius Heel-Potentised Swine Organ Preparations D10/D30/D200. "
4.	SilkFDA Link 08/01/1995 - "Alternatively, the ranula can be treated with the placement of a silk suture or seton into the dome of the cyst. "
5.	Type A Botulinum Toxins (Botulinum A Toxin)FDA Link 01/01/2008 - "We report an innovative method for ranula by using botulinum toxin type A on 3 patients. " 01/01/2008 - "Ranula successfully treated by botulinum toxin type A: report of 3 cases."
6.	Dental Implants (Dental Implant)IBA 08/01/2006 - "Plunging ranula formation as a complication of dental implant surgery: a case report."
7.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 10/01/1989 - "We have used a technique of fibrin glue injection into the cystic space of the ranula after it had been evacuated by aspiration. " 10/01/1989 - "Fibrin glue in the surgical treatment of ranulas."
8.	Antithyroid Agents (Antithyroid Drugs)IBA 10/18/1959 - "[A new treatment of ranula: synthetic antithyroid agents. "
9.	SiliconesIBA 01/01/2005 - "It is suggested to use silicone membrane in operations of plastic cystotomy in cases of ranula. "
10.	RNA (Ribonucleic Acid)IBA 06/01/2011 - "Various concentrations of HIV-1 RNA were found in ranula fluid, which appears to serve as a viral reservoir in HIV-infected patients."

Therapies and Procedures

1.	Sclerotherapy 02/01/2014 - "Although sclerotherapy is applied for plunging ranula, it can be primarily treated with surgery such as marsupialization, simple excision, and transcervical excision. " 12/01/2011 - "A variety of surgical procedures have been quoted in the literature ranging from marsupialization, excision of the ranula, sclerotherapy, and excision of the sublingual gland. " 09/01/2008 - "The size of the ranula was compared before and after sclerotherapy. " 09/01/2008 - "Plunging ranula may be also primarily treated with nonsurgical sclerotherapy, but there is little experience in pediatric patients. " 02/01/2006 - "Twenty of 26 patients (77%) showed a complete response after sclerotherapy: higher in plunging ranula (86%) than in intraoral ranula (74%). "
2.	Intralesional Injections 06/01/2006 - "To assess the efficacy of treatment of a ranula in children by intralesional injection of OK-432. " 06/01/2006 - "Treatment of ranula in pediatric patients with intralesional injection of OK-432." 05/01/2006 - "Twenty-one patients with plunging ranula were treated with intralesional injection of OK-432. " 03/01/2005 - "The intralesional injection of OK-432 has been proposed as an effective treatment of lymphangiomas and ranulas. " 01/01/1994 - "In the present study, we report on 2 cases in whom we conducted intralesional injection of OK-432 for cervical lymphangioma and ranula found in 20 and 35 year-old female patients. "
3.	Highly Active Antiretroviral Therapy (HAART) 07/01/2013 - "This study suggests that HAART might present a potential therapeutic effect on ranula in HIV-positive patients." 07/01/2013 - "The study includes a retrospective observation of 3 patients who were initially part of a prospective study on the comparative effect of HAART on ranulas in 14 HIV-positive patients. " 07/01/2013 - "The study's aim was to assess the potential therapeutic effect of highly active antiretroviral therapy (HAART) on ranulas in human immunodeficiency virus (HIV)-positive patients. " 07/01/2013 - "The effect of HAART on ranula was assessed at 3, 6 and 12 month. " 07/01/2013 - "The potential impact of highly active antiretroviral therapy on the treatment and epidemiology of ranula in human immunodeficiency virus-positive patients."
4.	Oral Surgery (Maxillofacial Surgery) 03/01/2011 - "The clinical histories of patients diagnosed with oral ranula, seen between 1998 and 2008 at the Oral and Maxillofacial Surgery Unit of a reference Children 's Hospital (0-14 years) were reviewed. " 07/01/2004 - "To retrospectively study the prevalence, age and gender distribution, the HIV serostatus of ranula patients and the trend in prevalence of ranula and Kaposi's sarcoma (KS) in patients at the two largest referral Oral and Maxillofacial Surgery specialist centres in Harare, Zimbabwe. "
5.	Low-Level Laser Therapy (LLLT) 11/01/2012 - "The aim of this preliminary study was to investigate the influence of low level laser therapy (LLLT) in alleviating pain caused by micro-marsupialization and the healing of oral ranulas and selected mucoceles. "