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Ranitidine (Zantac)

A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.

Also Known As:

Zantac; Ranitidin; AH-19065; Biotidin; N (2-(((5-((Dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine; Ranisen; Ranitidine Hydrochloride; Sostril; Zantic; AH 19065; AH19065; Hydrochloride, Ranitidine; 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-

Networked: 2073 relevant articles (355 outcomes, 480 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Furans: 53
    - Ranitidine: 2073

Experts

1.	Tamaddonfard, Esmaeal: 7 articles (06/2015 - 03/2008)
2.	Ciociola, A A: 6 articles (11/2004 - 07/2000)
3.	Farshid, Amir Abbas: 4 articles (06/2015 - 02/2010)
4.	Khalilzadeh, Emad: 4 articles (01/2011 - 03/2008)
5.	Halici, Zekai: 4 articles (01/2010 - 11/2004)
6.	Roth, Robert A: 4 articles (07/2008 - 07/2004)
7.	Ganey, Patricia E: 4 articles (07/2008 - 07/2004)
8.	Hawkey, C J: 4 articles (10/2007 - 09/2002)
9.	Naesdal, J: 4 articles (04/2007 - 09/2002)
10.	Yeomans, N D: 4 articles (04/2007 - 09/2002)

Related Diseases

1.	Duodenal Ulcer (Curling's Ulcer) 06/01/1995 - "The purpose of this study was to investigate if the use of a higher night time dose of ranitidine (300 mg) could keep significantly more duodenal ulcer patients in remission than the usual maintenance dose (150 mg). " 04/01/1991 - "We conclude that ranitidine is effective in preventing NSAID-associated duodenal ulcers and may be appropriate prophylaxis for certain high-risk patients." 08/01/1992 - "These results show that in patients with acute duodenal ulcer, 300 mg ranitidine administered at the end of the evening meal provides better control of nocturnal acidity than administration at bedtime and hence is suggested for optimization of therapeutic efficacy." 01/01/1992 - "While it is well-established that ranitidine 150 mg/day is effective in preventing recurrence and complications of duodenal ulcer, the economic impact of maintenance therapy is unknown. " 05/10/1990 - "We conclude that long-term, continuous treatment with ranitidine is effective in maintaining remission of duodenal ulcers, protects the patients against the risk of complications, and is safe."
2.	Ulcer 02/13/1982 - "Ranitidine appears to be a safe and highly effective treatment of gastric ulceration, with about 90% of ulcers healed after eight weeks." 12/01/2005 - "The clinical effects of the combination of Jianweiyuyang granules and ranitidine capsules were better than those of western medicine, with improvement in symptoms and syndrome (P < 0.01 to 0.05), but there was not significant difference with the rate of ulcer healing and the Hp clearance among the combination of Jianweiyuyang granules and ranitidine capsules, Jianweiyuyang granules, and ranitidine capsules (P > 0.05). " 08/01/1985 - "Nocturnal gastric acid inhibition was significantly greater in patients who responded to ranitidine than in those whose ulcer did not heal. " 06/01/1982 - "Ulcer symptoms resolved or improved in a greater proportion of patients on ranitidine, and this was associated with a significantly lower antacid consumption. " 02/01/1990 - "Other ulcer related symptoms such as fullness etc. were more rapidly relieved with ranitidine. "
3.	Stomach Ulcer (Gastric Ulcer) 06/10/1990 - "The results of this trial suggest that, in the treatment of gastric ulcers, the early-evening administration of ranitidine 300 mg is more effective than other modes of ingestion." 11/01/1996 - "Compared with placebo, ranitidine was more effective in maintaining healed gastric ulcers regardless of previous gastric ulcer history, smoking status, age (< 65 vs > or = 65 years), or sex. " 07/01/1993 - "Ranitidine 150 mg twice daily is effective for the treatment of gastric ulcers. " 07/01/1993 - "Ranitidine 300 mg at bedtime is effective for gastric ulcers: a 12-wk, multicenter, randomized, double-blind, placebo-controlled comparison. " 12/01/1989 - "The results suggest that ranitidine is effective in preventing gastric ulcer relapse."
4.	Peptic Ulcer (Peptic Ulcers) 09/01/1985 - "Ranitidine 300 mg hs appears to be equally safe and effective as the standard regimen of 150 mg bid in the short-term treatment of uncomplicated gastroduodenal ulcer." 06/01/1984 - "Ranitidine--new relief for peptic ulcers." 11/01/2006 - "We conducted a literature review of clinical trials examining use of ranitidine 150 mg twice daily to heal gastroduodenal ulcers (GU) in NSAID recipients. " 03/01/1991 - "The study shows that ranitidine 150 mg twice daily effectively heals NSAID associated peptic ulcers. " 03/01/1991 - "In a multicentre study the effect of ranitidine on healing non-steroidal anti-inflammatory drug (NSAID) associated peptic ulcers was compared in a group of patients who had stopped NSAID treatment with another group who continued with NSAID treatment. "
5.	Heartburn (Pyrosis) 04/01/1999 - "To compare the efficacy of dosing ranitidine 75 mg or placebo 30 min prior to a proven heartburn-provoking meal in completely preventing or reducing subsequent heartburn symptoms. " 06/01/1987 - "However, the 89 evaluable ranitidine-treated patients with normal endoscopy also experienced a marked and rapid reduction in heartburn at the end of 1 wk. The symptomatic improvement in the endoscopically abnormal ranitidine patients was significantly greater (p less than 0.05) than that observed in the endoscopically normal ranitidine group. " 10/01/1983 - "The results of a six week double blind placebo controlled trial (stage I) in 36 patients shows that ranitidine (150 mg bd) is superior to placebo in the acute treatment with significant symptomatic improvement concerning heartburn and regurgitation, and in healing or improvement of endoscopic lesions. " 04/01/1999 - "All three ranitidine doses were statistically significantly superior to placebo in providing overall episodic heartburn relief for the first episode (P < 0.002), last episode (P</=0.004), and all episodes combined (P < 0.001). " 04/01/1999 - "The ranitidine 75 mg regimen was clinically (> 10 percentage points) and statistically (P < 0.05) significantly more effective than placebo for all measured efficacy end-points in relieving heartburn and reducing antacid consumption. "

Related Drugs and Biologics

1.	Omeprazole (Esomeprazole)
2.	Cimetidine (Biomet)
3.	Famotidine (Pepcid)
4.	pantoprazole (Protonix)
5.	Sucralfate (Carafate)
6.	lansoprazole (Prevacid)
7.	Histamine (Histamine Dihydrochloride)
8.	Misoprostol (Cytotec)
9.	Nizatidine (Axid)
10.	Ranitidine (Zantac)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Blood Transfusion (Blood Transfusions)
3.	Endoscopic Hemostasis
4.	Sclerotherapy
5.	Premedication