Radium

Radium. A radioactive element of the alkaline earth series of metals. It has the atomic symbol Ra, atomic number 88, and atomic weight 226. Radium is the product of the disintegration of uranium and is present in pitchblende and all ores containing uranium. It is used clinically as a source of beta and gamma-rays in radiotherapy, particularly BRACHYTHERAPY.

Networked: 1635 relevant articles (32 outcomes, 75 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fosså, Sophie D: 8 articles (01/2013 - 01/2002)
2.	Holte, H: 5 articles (05/2012 - 09/2000)
3.	Petrylak, Daniel P: 4 articles (12/2015 - 03/2012)
4.	Bjerkehagen, Bodil: 4 articles (01/2009 - 09/2002)
5.	Bruland, Oyvind S: 3 articles (04/2015 - 01/2009)
6.	Sandstad, B: 3 articles (09/2011 - 11/2005)
7.	Holte, Harald: 3 articles (12/2009 - 09/2005)
8.	Saeter, Gunnar: 3 articles (01/2008 - 09/2002)
9.	Hall, Kirsten Sundby: 3 articles (01/2008 - 09/2002)
10.	Leenhouts, H P: 3 articles (09/2002 - 06/2000)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2015 - "This situation has changed with the introduction of radium 223 because of evidence of improved survival in patients, the good safety profile and the opportunity to avoid clonal selection of tumor cells. " 09/01/1977 - "Only a therapy scheme which parts from the good results of the long term radium therapy in combination with an adequately dosed and distributed deep therapy has a chance to replace the radium therapy of gynecological tumors in the long run." 01/01/1919 - "Non-Operable Tumor of the Orbit and Brow, Treated Successfully with Radium. " 11/01/1993 - "In 1912 many physicians considered radium a cure for cancer but few could afford it because radium cost a fortune. " 12/18/1909 - "IS RADIUM A CURE FOR CANCER?"
2.	Carcinoma (Carcinomatosis) 01/01/1977 - "The results of treatment of 30 patients with penis carcinoma cured with radium and 18 patients treated with 192Ir were compared. " 06/01/1953 - "[Comparative efficacy of radium and roentgen contact irradiation in skin carcinoma]." 10/01/1952 - "[Giant carconohematometra six years after cervical carcinoma apparently cured by radium and x-ray treatment]." 01/01/1949 - "Probable trends in the irradiation treatment of carcinoma of the cervix uteri with the improved expanding type of radium applicator." 12/01/1947 - "Analysis of technical factors and results of treatment in carcinoma of the cervix uteri; description of improved radium applicator."
3.	Prostatic Neoplasms (Prostate Cancer) 11/01/2013 - "Prostate cancer: radium-223: a new treatment option for bone-metastatic CRPC." 07/28/2014 - "The α emitter (223)Radium dichloride is the first radiopharmaceutical that significantly prolongs life in castrate resistant prostate cancer patients with wide-spread bone metastatic disease. " 04/01/2014 - "Radium 223 has huge potential in combination strategies as well as for use earlier in the natural history of metastatic prostate cancer." 12/01/2013 - "We present a concise review on the therapeutic use of 223Ra dichloride in this clinically important setting including excerpts on the radium history, physical properties, the alpharadin in symptomatic prostate cancer clinical trial, and practical information on its use in the clinic. " 09/30/2013 - "Radium - 223 (Xofigo) for prostate cancer."
4.	Neoplasm Metastasis (Metastasis) 07/01/2015 - "Radium-223 dichloride (radium-223 [Xofigo]) is a first-in-class α-emitting radiopharmaceutical shown to significantly prolong overall survival in patients with CRPC with symptomatic bone metastases and no visceral metastases. " 07/01/2015 - "Radium-223: Optimizing Treatment and Research of Osteoblastic Bone Metastasis." 08/01/2013 - "Collectively, these results suggest that radium Ra 223 dichloride is a promising candidate for managing bone metastases in patients with CRPC. " 02/01/2013 - "To prospectively evaluate the efficacy and safety of three different doses of radium chloride (Ra 223) in patients with CRPC and bone metastases. " 10/01/2011 - "On the other hand, for targeting bone metastases, 223Ra is the ideal radionuclide because simple cationic radium can be used for this purpose. "
5.	Osteosarcoma (Osteogenic Sarcoma) 11/01/2015 - "Osteosarcoma survivors (n=8) previously treated at the Norwegian Radium Hospital, Oslo University Hospital, participated in the study. " 07/01/1987 - "Toxicity studies using rodents have shown that the long-lived radium isotope radium 226 is about six times less toxic per unit of absorbed radiation dose to the skeleton than the short-lived isotope radium 224 with respect to the production of osteosarcoma. " 05/01/2015 - "Alpha Emitter Radium 223 in High-Risk Osteosarcoma: First Clinical Evidence of Response and Blood-Brain Barrier Penetration." 01/01/2009 - "Synchronous and metachronous skeletal osteosarcomas: the Norwegian Radium Hospital experience." 07/01/2002 - "The authors found no evidence that radium, at current levels in Wisconsin drinking water, resulted in excess cases of osteosarcoma."

Related Drugs and Biologics

1.	sipuleucel-T (APC8015)
2.	4- acetoxy- 13- ((3- ((tert- butoxycarbonyl)amino)- 2- hydroxy- 3- phenylpropanoyl)oxy)- 1- hydroxy- 7,10- dimethoxy- 9- oxo- 5,20- epoxytax- 11- en- 2- yl benzoate
3.	abiraterone
4.	Radon
5.	Iridium
6.	Uranium
7.	Cesium
8.	Halothane (Fluothane)
9.	Hormones
10.	Thorium

Related Therapies and Procedures

1.	Radiotherapy
2.	Castration
3.	Drug Therapy (Chemotherapy)
4.	Hysterectomy
5.	Brachytherapy