Radioisotopes (Radionuclides)

Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Also Known As:

Networked: 1836 relevant articles (78 outcomes, 201 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Goldenberg, David M: 25 articles (01/2015 - 05/2002)
2.	Sharkey, Robert M: 16 articles (01/2015 - 05/2002)
3.	Press, Oliver W: 10 articles (07/2015 - 05/2002)
4.	Barbet, Jacques: 9 articles (01/2015 - 05/2002)
5.	Bao, Ande: 9 articles (09/2014 - 01/2005)
6.	Chang, Chien-Hsing: 9 articles (10/2012 - 05/2002)
7.	Rossi, Edmund A: 9 articles (10/2012 - 05/2002)
8.	Brechbiel, Martin W: 9 articles (09/2012 - 04/2002)
9.	Pagel, John M: 8 articles (07/2015 - 11/2010)
10.	Wilbur, D Scott: 8 articles (07/2015 - 05/2002)

Related Diseases

1.	Neoplasms (Cancer) 08/11/2005 - "Since group C presented a greater promise for tumor accumulation, it represents, to date, the most suitable candidate for radiolabeling with long-lived positron emission tomography (PET) radioisotopes." 05/01/2002 - "One promising approach involving pretargeted delivery of radionuclides has been shown to be capable of significantly increasing the radioactive uptake in tumor relative to normal organs, thereby potentially improving the efficacy of both detection and therapy of cancer. " 01/01/2005 - "Based on these findings, the use of higher beta-energy radionuclides, such as 188Re and 90Y is more effective in delivering a higher absorbed dose to the tumor center at tumor diameters around 10 mm." 10/01/1999 - "Metallic radionuclides provide higher tumor radiation doses but not necessarily an improved therapeutic index, that is, the ratio of tumor:normal tissue radiation doses. " 01/01/2013 - "Among these radionuclides, Cobalt-60, incorporated in Telecobalt Unit, is commonly used in therapeutic treatment of cancer. "
2.	Pain (Aches) 06/01/2005 - "Radioisotopes are effective in providing pain relief with response rates of between 40% and 95%. " 07/01/2007 - "In some selected cases use of radioisotopes and other noninvasive or minimally invasive techniques may be useful in the management of metastatic bone pain. " 05/01/2013 - "(18)F-fluoride PET/CT may be helpful in deciding if the implementation of bone pain palliation using bone-seeking radionuclides at pain onset is necessary." 01/01/2005 - "The pain, which was the rationale to use the radioactive isotopes, was relieved and the patients restored their previous mobility. " 09/02/2004 - "The mechanism by which pain is relieved with the use of radionuclides is still not yet completely understood, however, the treatment is simple and provides a low risk of mielotoxicity. "
3.	Neoplasm Metastasis (Metastasis) 02/15/2010 - "Targeted RIT with beta-emitting radionuclides seems not to be effective in microscopic disease, because metastases developed at sites without previously known disease." 04/01/2012 - "This article offers a narrative review of bone-seeking radionuclides, examines the evidence of safety and efficacy for the treatment of painful skeletal metastases, and presents guidelines for their appropriate use in this patient population. " 01/01/2012 - "The goal of the study was to evaluate and compare the effectiveness of treatment with radionuclides of strontium-89 and samarium-153 in patients with generalized bone metastases. " 03/01/2015 - "We hypothesized that sentinel lymph node biopsy (SLNB) of the lateral neck compartment with radioisotopes may detect occult metastasis, which could prevent recurrence. " 08/01/2014 - "New targeted therapies and radionuclides are promising option for treatment of bone metastases but still under investigation. "
4.	Lymphoma (Lymphomas) 11/01/2001 - "These mAbs can also be used to guide radionuclides to the lymphoma. " 03/01/1987 - "CT in particular, and to a lesser extent ultrasound and radionuclides, now plays an important part in helping the clinician to manage patients with lymphoma. " 08/01/1963 - "THE USE OF RADIOACTIVE ISOTOPES IN THE TREATMENT OF LYMPHOMAS." 01/01/2001 - "Conjugating MAbs to radionuclides is a strategy for improving the efficacy of MAb lymphoma therapy by delivering radiation in close proximity to the tumour (radioimmunotherapy or RIT). " 04/01/2011 - "Radioimmunotherapy (RIT) makes use of continuous low dose radiation emitted by radioisotopes targeted directly to the lymphoma cells. "
5.	Leukemia 02/01/1996 - "The goals of this study were to learn whether the DOTA chelator was useful for targeting lead radionuclides (203,212 Pb) to cells and tissues invaded by the Rauscher leukemia virus (RVB3) and to investigate the therapeutic efficacy of targeted 212Pb in treating the murine leukemia. " 01/01/2009 - "This suggests that the observed high rates of infant leukemias may be a teratogenic effect from incorporated radionuclides. " 09/01/2008 - "[Biological cycle of radionuclides and dynamics of cattle leukemia in the Orenburg region]." 11/01/2003 - "In human, higher risk of leukemia is reported in the children of fathers who had been exposed to radionuclides at the nuclear reprocessing plants or to diagnostic doses of radiation. " 05/01/1994 - "No significant difference was marked in hemoblastoses (excluding acute leukemia) in non-contaminated and contaminated with radionuclides regions of the district, and in contaminated zones depending on effective equivalent doze. "

Related Drugs and Biologics

1.	Antibodies
2.	Monoclonal Antibodies
3.	Antigens
4.	Liposomes (Liposome)
5.	Diphosphonates
6.	Somatostatin (Somatotropin Release-Inhibiting Factor)
7.	Somatostatin Receptors (Somatostatin Receptor)
8.	Peptide Receptors (Peptide Receptor)
9.	Cytotoxins
10.	Iodine

Related Therapies and Procedures

1.	Radioimmunotherapy
2.	Radiotherapy
3.	Brachytherapy
4.	Heterologous Transplantation (Xenotransplantation)
5.	Drug Therapy (Chemotherapy)