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Radiation-Sensitizing Agents

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Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.

Also Known As:

Agents, Radiation-Sensitizing; Radiation Sensitizers; Radiation Sensitizing Agents; Radiation-Sensitizing Drugs; Radiosensitizing Drugs; Agents, Radiation Sensitizing; Agents, Radiosensitizing; Drugs, Radiation-Sensitizing; Drugs, Radiosensitizing; Radiation Sensitizing Drugs; Sensitizers, Radiation; Sensitizing Agents, Radiation; Radiosensitizing Agents

Networked: 136 relevant articles (10 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 56
  - Physiological Effects of Drugs: 1
    - Radiation-Sensitizing Agents: 136
      - Photosensitizing Agents: 894

Experts

1.	Lawrence, Theodore S: 3 articles (03/2004 - 01/2003)
2.	Mehta, Minesh P: 2 articles (03/2012 - 11/2005)
3.	Khuntia, Deepak: 2 articles (03/2012 - 11/2005)
4.	Rich, Tyvin A: 2 articles (05/2005 - 08/2003)
5.	Dawson, Laura A: 2 articles (03/2004 - 01/2003)
6.	Harrington, K J: 2 articles (04/2001 - 12/2000)
7.	Vile, R G: 2 articles (04/2001 - 12/2000)
8.	Peters, A M: 2 articles (04/2001 - 12/2000)
9.	Stewart, J S: 2 articles (04/2001 - 12/2000)
10.	Zhang, Yonggang: 1 article (12/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1988 - "There is good reason to believe that improvement in local tumor control can be expected by the addition of chemotherapeutic agents, specifically designed radiation sensitizers, and differentiation-inducing agents, as well as by the manipulation of dose rates and dose distributions. " 04/01/2011 - "Even though radiation alone may result in low local recurrence rates, the use of additional radiosensitizing agents may provide an increase in local disease control in addition to improved tumor regression rates. " 10/15/2010 - "The study demonstrated the ability of hydroxychalcones to radiosensitize cancer cells and provides new leads for developing novel radiation sensitizers." 12/01/2015 - "Systemic treatment with these radiation-sensitizing agents selectively enhanced the potency of external beam radiation therapy for established PSMA-positive tumors. " 08/01/2015 - "NPs can either encapsulate radiation sensitizing agents, thereby protecting them from degradation, or sensitize cancer cells to ionizing radiation via their physicochemical properties, e.g. "
2.	Brain Neoplasms (Brain Tumor) 09/01/2004 - "These technological developments and newly designed radiosensitizing agents will improve local control rates and survival times, thereby enhancing the quality of life in patients suffering from various kinds of brain tumors." 03/01/1972 - "[Clinical and experimental results of interstitial Brachy-Curie-therapy combined with radiation sensitizing agents in infiltrative growing brain neoplasms]." 01/01/1980 - "The use of radiosensitizing agents with more novel radiation therapy fractionations and in combination with adjunctive drug therapies holds some promise for improving the disappointing results obtained thus far with chemotherapy for malignant brain tumors." 01/01/1972 - "[Clinical and experimental results of interstitial Curie-therapy combined with radiosensitizing agents in DS carcinoma of the rat and in infiltrating brain neoplasms]." 11/01/2005 - "Newer radiosensitizing agents (e.g., efaproxiral [RSR-13] and motexafin gadolinium) have shown promise in the treatment of brain tumors, especially in specific patient subsets. "
3.	Carcinoma (Carcinomatosis) 01/01/1970 - "Effect of radiation-sensitizing agents in radiation therapy of mouse mammary carcinoma." 05/15/1981 - "Surgical adjuvant therapy in colon carcinoma: a human tumor spheroid model for evaluating radiation sensitizing agents." 01/01/1972 - "[Clinical and experimental results of interstitial Curie-therapy combined with radiosensitizing agents in DS carcinoma of the rat and in infiltrating brain neoplasms]." 01/01/1991 - "In cervical carcinoma, trials utilizing a variety of radiation-sensitizing agents have failed to demonstrate superiority over that of hydroxyurea, which has been shown to improve survival in advanced disease. " 01/01/1987 - "The continued investigation into the use of radiation sensitizers in cervical carcinoma is of interest and several studies using weekly low-dose cisplatin have established the feasibility of this approach, although long-term survival benefits have not yet been documented. "
4.	Genomic Instability 12/21/2007 - "Further study of the 12 radiation susceptibility genes identified in this screen may help to elucidate the molecular mechanisms of cell cycle progression, DNA repair, cell death, cell growth and genomic instability, and to develop new radiation sensitizing agents for radiotherapy."
5.	Fever (Fevers) 01/01/1996 - "Some new trends of this therapy are also mentioned (hyperbaric oxygenation, radiosensitizing agents, hyperthermia etc.). " 05/01/1990 - "This paper reviews the rationale and clinical results with the use of altered fractionation schemes, brachytherapy, radiation sensitizers, hyperthermia, particle therapy, and radiosurgery in the treatment of these patients. " 07/01/1982 - "These are planning with CT Scan, conformation radiotherapy, radiation sensitizers and protectors, hyperfractionation, hyperthermia, intraoperative radiotherapy, heavy particle radiotherapy and isotopic immunoglobulin therapy." 01/01/1999 - "Hyperthermia may enhance the effect of both radiotherapy and chemotherapy, and newer radiosensitizing agents also need evaluating. " 02/15/1993 - "To increase tumor control, research is being conducted combining irradiation with chemotherapy, radiation sensitizers, hyperthermia, and new modalities such as neutron irradiation. "

Related Drugs and Biologics

1.	Oxygen
2.	Hydroxyurea (Hydrea)
3.	Misonidazole
4.	Etanidazole
5.	Hemoglobins (Hemoglobin)
6.	Emulsions
7.	motexafin gadolinium
8.	efaproxiral (RSR-13)
9.	Fluosol-DA
10.	carbogen

Related Therapies and Procedures

1.	Radiotherapy
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Immunotherapy
5.	Brachytherapy