Quinidine (Chinidin)

An optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.

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Networked: 1482 relevant articles (91 outcomes, 126 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Antzelevitch, Charles: 8 articles (01/2016 - 01/2005)
2.	Belhassen, Bernard: 8 articles (12/2015 - 09/2004)
3.	Viskin, Sami: 6 articles (12/2015 - 09/2004)
4.	Huang, Christopher L-H: 5 articles (06/2012 - 01/2007)
5.	Pope, Laura E: 4 articles (11/2014 - 05/2006)
6.	Borggrefe, Martin: 4 articles (06/2007 - 01/2005)
7.	Wolpert, Christian: 4 articles (06/2007 - 01/2005)
8.	Schimpf, Rainer: 4 articles (06/2007 - 01/2005)
9.	Glick, Aharon: 3 articles (12/2015 - 09/2004)
10.	Arguin, Paul M: 3 articles (10/2015 - 07/2010)

Related Diseases

1.	Atrial Fibrillation 10/01/1990 - "Thus, quinidine treatment is more effective than no antiarrhythmic therapy in suppressing recurrences of atrial fibrillation but appears to be associated with increased total mortality." 09/01/2005 - "Quinidine is effective for treatment of atrial fibrillation (AF) in horses, but often accelerates ventricular response rate. " 12/01/2001 - "Oral quinidine was safe and effective in the conversion of persistent atrial fibrillation to sinus rhythm." 04/15/1984 - "Intravenous quinidine therapy was a safe and effective means of converting the acute onset of atrial fibrillation to normal sinus rhythm in anesthetized horses." 04/01/1973 - "Electrocardiography for diagnosis and control of efficacy of oral quinidine sulfate in a case of atrial fibrillation in a Holstein cow."
2.	Ventricular Tachycardia 07/01/2012 - "Vasospastic angina with J-wave pattern and polymorphic ventricular tachycardia effectively treated with quinidine." 04/01/1995 - "Nineteen patients with inducible ventricular tachycardia underwent serial electrophysiologic studies for evaluation of quinidine efficacy. " 08/01/1992 - "Isointegral ECG body surface mapping was performed in 51 patients with inducible ventricular tachycardia having programmed stimulation studies at baseline and after oral quinidine therapy. " 12/01/1984 - "Intravenous quinidine by intermittent bolus for electrophysiologic studies in patients with ventricular tachycardia." 04/01/2013 - "Premature ectopic beats and monomorphic ventricular tachycardia were observed in 50% of quinidine-treated heart preparations. "
3.	Brugada Syndrome 03/01/2009 - "The long-term reproducibility of the EP efficacy of quinidine in patients with idiopathic VF and Brugada syndrome is excellent. " 01/01/2013 - "We report two cases of Brugada syndrome that presented with electrical storm and were treated successfully with oral quinidine, an "endangered species" drug. " 09/28/2004 - "Efficacy of quinidine in high-risk patients with Brugada syndrome." 12/01/2015 - "Quinidine in Brugada Syndrome: Still a Long Way to Go…." 07/01/2013 - "To examine the effectiveness of WK, alone and in combination with quinidine, to suppress arrhythmogenesis in an experimental model of Brugada syndrome (BrS). "
4.	Cardiac Arrhythmias (Arrythmia) 11/15/2013 - "Among them one compound showed characteristics similar to quinidine in different arrhythmia models as well as electrocardiogram (ECG) studies which suggests that it possesses not only α1-adrenoceptor blocking properties but also affinity for cardiac Na(+) and K(+) channels, similar to class IA antiarrhythmic agents. " 02/01/2007 - "The aim of this study was to evaluate the pharmacokinetics and pharmacodynamics of quinidine-induced QT prolongation in healthy Caucasian and Korean subjects to investigate interethnic differences in susceptibility to drug-induced arrhythmia. " 12/15/2015 - "Gender had no influence on arrhythmia recurrence: 1 year after quinidine initiation, Kaplan-Meier probability of freedom from recurrent arrhythmia was 62.4% in men and 57.9% in women (p = 0.33). " 12/15/2015 - "Time to quinidine discontinuation and arrhythmia recurrence were evaluated using Cox proportional hazards models. " 03/01/2014 - "The case highlights the importance of quinidine for management of ventricular arrhythmias in the context of early repolarisation and suggests that J wave amplitude may be an important indicator of therapeutic drug levels and arrhythmia susceptibility. "
5.	Tachycardia (Tachyarrhythmias) 05/01/2005 - "In 1 patient, quinidine was effective in eliminating both ST-segment elevation and repetitive tachyarrhythmia episodes. " 09/01/2012 - "Oral quinidine therapy converted the tachyarrhythmia to sinus rhythm. " 03/01/2011 - "In five of six hearts, 10 μM quinidine slowed the frequency but did not terminate the tachyarrhythmia. " 10/01/2006 - "Quinidine proved to be efficient in prolonging the QT interval and rendering ventricular tachyarrhythmias non-inducible in patients with a mutation in KCNH2 (HERG). " 10/01/2005 - "Furthermore, in patients with a mutation in HERG (SQT1), quinidine rendered ventricular tachyarrhythmias noninducible and restored the QT interval/heart rate relationship toward a reference range. "

Related Drugs and Biologics

1.	Procainamide (Procan)
2.	Amiodarone (Amiodarona)
3.	Propafenone (Rythmol)
4.	Verapamil (Calan)
5.	Disopyramide (Norpace)
6.	Flecainide (Tambocor)
7.	Sotalol (Sotalol Hydrochloride)
8.	Dextromethorphan (Levomethorphan)
9.	Quinine (Quinson)
10.	Lidocaine (Xylocaine)

Related Therapies and Procedures

1.	Electric Countershock (Cardioversion)
2.	Oral Administration
3.	Drug Therapy (Chemotherapy)
4.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
5.	Ligation