Quinestrol (Estrovis)

The 3-cyclopentyl ether of ETHINYL ESTRADIOL. After gastrointestinal absorption, it is stored in ADIPOSE TISSUE, slowly released, and metabolized principally to the parent compound. It has been used in ESTROGEN REPLACEMENT THERAPY. (From AMA Drug Evaluations Annual, 1992, p1011)

Also Known As:

Networked: 23 relevant articles (0 outcomes, 1 trials/studies)

Drug Context: Research Results

Experts

1.	Liu, Ming: 3 articles (10/2019 - 01/2012)
2.	Zhang, Zhibin: 2 articles (10/2019 - 01/2012)
3.	Chen, Funing: 2 articles (12/2014 - 10/2014)
4.	Chen, Yaoxing: 2 articles (12/2014 - 10/2014)
5.	Li, Jian: 2 articles (12/2014 - 10/2014)
6.	He, Siyuan: 1 article (11/2022)
7.	Wang, Yong: 1 article (11/2022)
8.	Wu, Kangjuan: 1 article (11/2022)
9.	Zhang, Meiwen: 1 article (11/2022)
10.	Zhou, Xunjun: 1 article (11/2022)

Related Diseases

1.	Hemorrhage 07/01/1980 - " The bleeding pattern showed no statistical significance between the quinestrol-treated group and placebo group in terms of the overall effects on the following definitions: acceptable bleeding, amenorrhea, irregular bleeding and prolonged bleeding. " 07/01/1980 - " Hence, the use of quinestrol in this trial did not significantly change the bleeding pattern of depot-medroxyprogesterone acetate users." 09/01/1972 - " In order to induce periodic hemorrhage, 6 mg of the synthetic progestogen ethynodiol diacetate was added to the Quinestrol. " 07/01/1980 - "In a double-blind clinical trial the effect on the bleeding pattern disrupted by progesterone-only injectable contraception of quinestrol, an estrogen which is stored in body fat and is slowly released over days, was studied in 236 Thai women giving informed consent and having irregular or nonexistent bleeding patterns since the start of Depo-Provera contraception. "
2.	Body Weight (Weight, Body) 05/01/2020 - "Effect of quinestrol on body weight, vital organs, biochemicals and genotoxicity in adult male lesser bandicoot rat, Bandicota bengalensis." 12/01/2014 - "The pathways involved in quinestrol-induced spermatogenic apoptosis were studied in adult male rat by using daily intragastric administration of 0.01 mg/kg, 0.1 mg/kg and 1 mg/kg body weight quinestrol for two consecutive weeks. " 10/01/2014 - "The effects of quinestrol on spermatogenesis were investigated in adult male mice by daily intragastric administration of quinestrol with various doses of 5, 10, 50 and 100mg/kg body weight for 10 days. " 01/01/2011 - "The results showed that body weight significantly increased after quinestrol treatment, except in the group that received the highest dose. " 01/01/2011 - "The hypothesis that quinestrol exerts testicular damage via oxidative stress was investigated in male gerbils using a daily oral gavage of 3.5 mg/kg body weight for 2 weeks (the multidose-treated group) or 35 mg/kg body weight (the single-dose-treated group). "
3.	Infertility (Sterility) 04/01/1970 - "[Quinestrol therapy in cervical factor sterility]." 04/01/1967 - "Quinestrol therapy in functional infertility." 07/01/1966 - "Quinestrol therapy in functional infertility." 01/01/2012 - "These data demonstrate that quinestrol, alone or in combination with levonorgestrel, induces subfertility in male rats mainly by interfering with germ cell differentiation. " 02/01/1971 - "Combined therapy with quinestrol and clomiphene in functional sterility."
4.	Hyperplasia 01/01/1976 - " Cystic hyperplasia was found to occur spontaneously, particularly in nonlactators, and with greater severity in patients who had received a long-acting estrogenic agent (quinestrol) for lactation suppression." 02/01/1970 - "Endometrial biopsies indicated by their lack of hyperplasias that the quinestrol did not accumulate."
5.	Amenorrhea 03/01/1975 - "Post-partum amenorrhea showed a progressive prolongation from an average of 47.9 days in the controls to 64.6 and 72.6 days respectively in the 2 and 4 mg quinestrol groups. " 07/01/1980 - " The bleeding pattern showed no statistical significance between the quinestrol-treated group and placebo group in terms of the overall effects on the following definitions: acceptable bleeding, amenorrhea, irregular bleeding and prolonged bleeding. "

Related Drugs and Biologics

1.	Medroxyprogesterone Acetate (Depo-Provera)
2.	Levonorgestrel (Plan B)
3.	Estradiol Congeners (Synthetic Estrogens)
4.	Raloxifene Hydrochloride (Evista)
5.	Estrogen Receptor Modulators (Antiestrogen)
6.	Progesterone
7.	Progestins (Progestagens)
8.	Fertility Agents
9.	Ethynodiol Diacetate
10.	Estrogens (Estrogen)

Related Therapies and Procedures

1.	Therapeutics
2.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
3.	Injections
4.	Contraception (Birth Control)