Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)

A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

Also Known As:

Networked: 292 relevant articles (2 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gershwin, M Eric: 12 articles (11/2014 - 06/2002)
2.	Coppel, Ross L: 8 articles (11/2014 - 05/2003)
3.	Palmer, Jeremy M: 7 articles (12/2008 - 02/2002)
4.	Harris, Robert A: 6 articles (01/2015 - 06/2003)
5.	Ansari, Aftab A: 6 articles (11/2014 - 05/2003)
6.	Leung, Patrick S C: 6 articles (11/2014 - 05/2003)
7.	Stacpoole, Peter W: 6 articles (03/2013 - 06/2006)
8.	Jones, David E J: 6 articles (09/2008 - 02/2002)
9.	Kirby, John A: 5 articles (12/2008 - 02/2002)
10.	Gershwin, M E: 4 articles (02/2014 - 08/2000)

Related Diseases

1.	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 11/01/2004 - "The activity of the purified bovine pyruvate dehydrogenase complex was studied spectrophotometrically in presence of the serum (1: 1000) from five patients with primary biliary cirrhosis and from ten disease free controls. " 01/01/1995 - "Biliary epithelial expression of pyruvate dehydrogenase complex in primary biliary cirrhosis: an immunohistochemical and immunoelectron microscopic study." 09/23/1991 - "A major issue in the study of the pathogenesis of primary biliary cirrhosis is whether the E2 subunit of the pyruvate dehydrogenase complex (PDH-E2), the major autoantigen in the disease, exists as a tissue-specific isoform. " 08/27/2015 - "Role of Lipoylation of the Immunodominant Epitope of Pyruvate Dehydrogenase Complex: Toward a Peptide-Based Diagnostic Assay for Primary Biliary Cirrhosis." 08/01/2013 - "Primary biliary cirrhosis ensues from a multi-lineage loss of tolerance to the E2 component of the pyruvate dehydrogenase complex. "
2.	Hemorrhagic Shock 08/01/2000 - "We have demonstrated previously that dichloroacetate (DCA) treatment in rodents ameliorates, via activation of the pyruvate dehydrogenase complex, the cardiovascular depression observed after hemorrhagic shock. "
3.	Starvation 01/01/2008 - "The mitochondrial pyruvate dehydrogenase complex (PDC) is inactivated in many tissues during starvation and diabetes. " 08/01/2006 - "The PDC (pyruvate dehydrogenase complex) is strongly inhibited by phosphorylation during starvation to conserve substrates for gluconeogenesis. " 08/01/1999 - "Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes." 01/15/1987 - "Regulation of renal and hepatic pyruvate dehydrogenase complex on carbohydrate re-feeding after starvation. " 11/15/1985 - "Effects of administration of tri-iodothyronine on the response of cardiac and renal pyruvate dehydrogenase complex to starvation for 48 h."
4.	Leigh Disease (Leigh's Disease) 09/01/1999 - "This study reports a 38-year-old woman with adult Leigh syndrome associated with partial deficiency of the pyruvate dehydrogenase complex. " 06/01/2007 - "Deficiency of pyruvate dehydrogenase complex E1 alpha subunit (PDHA1) is the common cause of Leigh syndrome. " 08/01/2002 - "Mutations in the E3-binding protein component of pyruvate dehydrogenase complex have been demonstrated in a few cases of Leigh syndrome. " 12/01/1997 - "All three patients had non-pyruvate dehydrogenase complex (PDHC) deficiencies: two exhibited Leigh syndrome (complex I deficiency and unknown etiology), and one abnormal myelination (multienzyme deficiency), demonstrated on magnetic resonance imaging (MRI). " 08/01/1997 - "We report molecular analysis of thiamin-responsive pyruvate dehydrogenase complex (PDHC) deficiency in a patient with an X-linked form of Leigh syndrome. "
5.	Insulin Resistance 10/01/2013 - "Since the mitochondrial pyruvate dehydrogenase complex (PDC) controls the rate of carbohydrate oxidation, impairment of PDC activity mediated by high-fat intake has been advocated as a causative factor for the skeletal muscle insulin resistance, metabolic syndrome, and the onset of type 2 diabetes (T2D). " 05/01/2012 - "High-fat feeding inhibits pyruvate dehydrogenase complex (PDC)-controlled carbohydrate (CHO) oxidation, which contributes to muscle insulin resistance. " 06/01/1995 - "The pyruvate dehydrogenase complex: nutrient control and the pathogenesis of insulin resistance." 04/15/1987 - "The activity of the pyruvate dehydrogenase complex in heart and liver from mice during the development of obesity and insulin resistance." 12/01/2003 - "The purpose of this study was to determine whether changes in triglyceride concentration and/or altered pyruvate dehydrogenase complex (PDHc) activity contribute to the beta cell dysfunction, and to analyze the effect of dietary fish oil on the altered patterns of insulin secretion and peripheral insulin resistance. "

Related Drugs and Biologics

1.	Dichloroacetate (Dichloroacetic Acid)
2.	Antibodies
3.	Pyruvic Acid (Pyruvate)
4.	Autoantibodies
5.	Antigens
6.	Glucose (Dextrose)
7.	Dihydrolipoyllysine-Residue Acetyltransferase (Dihydrolipoyl Transacetylase)
8.	Enzymes
9.	Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)
10.	pyruvate dehydrogenase (acetyl-transferring) kinase (pyruvate dehydrogenase kinase)

Related Therapies and Procedures

1.	Ketogenic Diet
2.	Heterologous Transplantation (Xenotransplantation)
3.	Transplantation (Transplant Recipients)
4.	Intramuscular Injections