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Pyruvate Carboxylase

A biotin-dependent enzyme belonging to the ligase family that catalyzes the addition of CARBON DIOXIDE to pyruvate. It is occurs in both plants and animals. Deficiency of this enzyme causes severe psychomotor retardation and ACIDOSIS, LACTIC in infants. EC 6.4.1.1.
Also Known As:
Carboxylase, Pyruvate; Pyruvate:carbon-dioxide ligase (ADP-forming)
Networked: 183 relevant articles (1 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Jitrapakdee, Sarawut: 10 articles (03/2021 - 07/2007)
2. Shulman, Gerald I: 5 articles (11/2019 - 07/2013)
3. MacDonald, Michael J: 5 articles (01/2017 - 10/2008)
4. Liu, Yang: 4 articles (10/2021 - 01/2021)
5. Teegarden, Dorothy: 4 articles (04/2021 - 01/2017)
6. Phannasil, Phatchariya: 4 articles (03/2021 - 01/2015)
7. Liu, Chang: 3 articles (06/2021 - 01/2021)
8. Pan, Yu: 3 articles (06/2021 - 01/2021)
9. Zhang, Yifan: 3 articles (06/2021 - 01/2021)
10. Donkin, Shawn S: 3 articles (04/2021 - 01/2017)

Related Diseases

1. Insulin Resistance
2. Neoplasms (Cancer)
3. Breast Neoplasms (Breast Cancer)
4. Leigh Disease (Leigh's Disease)
5. Hepatocellular Carcinoma (Hepatoma)

Related Drugs and Biologics

1. Lipids
2. Enzymes
3. Glucose (Dextrose)
4. Glutamic Acid (Glutamate)
5. Glutamine (L-Glutamine)
6. Phosphates (Orthophosphate)
7. Alanine (L-Alanine)
8. Small Interfering RNA (siRNA)
9. Pyruvate Decarboxylase (Decarboxylase, Pyruvate)
10. Aspartic Acid (Aspartate)

Related Therapies and Procedures

1. Intravenous Infusions
2. Drug Therapy (Chemotherapy)
3. Therapeutics
4. Injections