Pyruvaldehyde (Methylglyoxal)

An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.

Also Known As:

Networked: 430 relevant articles (10 outcomes, 55 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wu, Lingyun: 17 articles (12/2011 - 03/2002)
2.	Thornalley, Paul J: 15 articles (06/2014 - 07/2005)
3.	Schalkwijk, Casper G: 9 articles (06/2015 - 09/2006)
4.	Rabbani, Naila: 9 articles (06/2014 - 10/2008)
5.	Ray, Manju: 8 articles (01/2015 - 06/2003)
6.	Brownlee, Michael: 8 articles (06/2014 - 01/2006)
7.	Münch, Gerald: 7 articles (01/2013 - 01/2005)
8.	Vasdev, Sudesh: 7 articles (12/2011 - 01/2004)
9.	Stehouwer, Coen D A: 6 articles (06/2015 - 04/2008)
10.	Pan, Tzu-Ming: 6 articles (07/2014 - 12/2012)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2010 - "Accumulative evidence suggests an important role of GLO1 expression in protection against methylglyoxal-dependent protein adduction and cellular damage associated with diabetes, cancer, and chronological aging. " 01/01/2008 - "Contrary to the effect of existing anticancer drugs, this methylglyoxal-based formulation is devoid of any toxic effect and reasonably effective against a wide variety of cancers. " 10/01/2011 - "Atomic force microscopic study demonstrated gross structural alteration specifically of tumor mitochondria on methylglyoxal treatment. " 09/01/2011 - "Together these studies demonstrate a specific effect of methylglyoxal on mitochondrial complex I of malignant cells and importantly some distinct alteration of this complex in cancer cells." 10/01/2009 - "These studies culminated in a recent investigation to evaluate a methylglyoxal-based formulation in treating a small group of cancer patients, and the results were promising. "
2.	Neuroblastoma 04/10/2015 - "The levels of ADTIQ and methylglyoxal were detected by LC-MS/MS. Here we report the chemical synthesis of ADTIQ, demonstrate its biosynthesis in SH-SY5Y neuroblastoma cell line and investigate its role in the pathogenesis of PD. " 10/15/2003 - "To this purpose, we comparatively evaluated the signaling transduction pathway elicited by methylglyoxal in human glioblastoma (ADF) and neuroblastoma (SH-SY 5Y) cells. " 12/05/2015 - "Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells." 06/01/2006 - "To simulate a reduced glyoxalase I activity, we applied an inhibitor of glyoxalase I, p-bromobenzylglutathione cyclopentyl diester (pBrBzGSCp(2)), to SH-SY5Y neuroblastoma cells to induce chronically elevated methylglyoxal concentrations. " 06/15/2015 - "The aim of this study was to investigate the role of sulforaphane, an isothiocyanate found in cruciferous vegetables, in counteracting methylglyoxal-induced damage in SH-SY5Y neuroblastoma cells. "
3.	Insulin Resistance 08/01/2009 - "The present study was designed to investigate whether methylglyoxal could directly induce insulin resistance and salt sensitivity in Sprague-Dawley rats. " 07/01/2014 - "In this work, we have evaluated the role of the AGE precursor methylglyoxal (MGO) in generating endothelial insulin resistance both in cells and in animal models. " 08/01/2009 - "These results indicate that methylglyoxal-induced insulin resistance and salt sensitivity at least in part by increasing oxidative stress and/or AGEs formation in Sprague-Dawley rats. " 08/01/2009 - "Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats." 11/25/2006 - "Methylglyoxal (MG), a highly reactive molecule, has been implicated in the development of insulin resistance. "
4.	Inflammation 05/01/2014 - "Furthermore, this study suggests a cascade linking inflammation, reduced GLO-1, methylglyoxal- and AGE-accumulation, and subsequent apoptosis. " 03/01/2015 - "Serum levels of methylglyoxal-derived hydroimidazolone-1 in diabetes patients are increased and associated with low-grade inflammation, but not yet arterial stiffness or wall thickness. " 06/26/2013 - "Abnormal cellular accumulation of the dicarbonyl metabolite methylglyoxal (MG) results in cell damage, inflammation, and oxidative stress. " 08/01/2012 - "The article deals with studying of the relationship between biologic reaction of inflammation with glycosylation reaction and content of methylglyoxal in blood serum. " 12/01/2008 - "Methylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells."
5.	Diabetic Nephropathies (Diabetic Nephropathy) 01/01/2014 - "The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy." 12/05/2013 - "Advanced glycation endproducts (AGEs) and its precursor methylglyoxal are associated with diabetic nephropathy (DN). " 03/01/2011 - "To investigate the association of plasma levels of methylglyoxal (MG) and markers of inflammation/endothelial dysfunction with diabetic nephropathy (DN). " 03/01/2011 - "Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy." 12/01/2014 - "(+)-Catechin ameliorates diabetic nephropathy by trapping methylglyoxal in type 2 diabetic mice."

Related Drugs and Biologics

1.	Copper
2.	Catechin (Z 7300)
3.	1- (5- hydroxy- 3- methyl- 1- phenyl- 1H- pyrazol- 4- yl)- 6- methyl- 1,3- dihydrofuro(3,4- c)pyridine- 7- ol
4.	vescalagin
5.	salvin
6.	Proteins (Proteins, Gene)
7.	Glucose (Dextrose)
8.	3-deoxyglucosone
9.	Glyoxal (Ethanedial)
10.	Advanced Glycosylation End Products

Related Therapies and Procedures

1.	Immunomodulation
2.	Peritoneal Dialysis
3.	Subcutaneous Injections
4.	Drug Therapy (Chemotherapy)
5.	Carbohydrate-Restricted Diet (Low Carbohydrate Diet)