Pyrrolnitrin

3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole. Antifungal antibiotic isolated from Pseudomonas pyrrocinia. It is effective mainly against Trichophyton, Microsporium, Epidermophyton, and Penicillium.

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Networked: 16 relevant articles (3 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dennert, Francesca: 2 articles (01/2017 - 01/2017)
2.	Maurhofer, Monika: 2 articles (01/2017 - 01/2017)
3.	Adam, Ariane: 2 articles (10/2007 - 11/2006)
4.	De Laurentis, Walter: 2 articles (10/2007 - 11/2006)
5.	Naismith, James H: 2 articles (10/2007 - 11/2006)
6.	van Pee, Karl-Heinz: 2 articles (10/2007 - 11/2006)
7.	Aellen, Nora: 1 article (01/2017)
8.	Bloemberg, Guido: 1 article (01/2017)
9.	Fesselet, Marie: 1 article (01/2017)
10.	Flury, Pascale: 1 article (01/2017)

Related Diseases

1.	Mycoses (Diseases, Fungus) 10/30/2007 - "Pyrrolnitrin is a commonly used and clinically effective treatment for fungal infections and provides the structural basis for the more widely used fludioxinil. " 05/01/1969 - "The antifungal activity of pyrrolnitrin, previously shown to be effective against superficial infections, was evaluated against experimental systemic mycoses. " 11/01/2006 - "Pyrrolnitrin is the active ingredient of drugs for the treatment of superficial fungal infections and was used as a lead structure for the development of fludioxonil. "
2.	Infections 05/01/1969 - "The antifungal activity of pyrrolnitrin, previously shown to be effective against superficial infections, was evaluated against experimental systemic mycoses. " 01/01/2017 - "Although virulence of mutants lacking one or several of the other antimicrobial compounds, i.e., 2,4-diacetylphloroglucinol, phenazines, pyrrolnitrin, or pyoluteorin, was not reduced, these metabolites might still play a role in an insect background since all investigated biosynthetic genes for antimicrobial compounds of strain CHA0 were expressed at some point during insect infection. "
3.	Tinea Pedis (Athlete's Foot) 01/01/1999 - "[Therapeutic efficacy of a topical antifungal solution preparation formulated with pyrrolnitrin and clotrimazole in combination (Pyroace W) in guinea pig model of tinea pedis]." 01/01/1999 - "The therapeutic efficacy of a topical antifungal solution containing a mixture of 0.2% pyrrolnitrin and 0.4% clotrimazole (Pyroace W) was tested in a guinea pig model of tinea pedis using a 1% newly solution formulated preparation of miconazole (Dermalin-L) as a reference drug. "
4.	Contact Dermatitis (Eczema, Contact) 01/01/1982 - "Contact dermatitis from pyrrolnitrin." 11/01/1981 - "Contact dermatitis from pyrrolnitrin." 10/01/1975 - "Contact dermatitis from pyrrolnitrin (an antimycotic agent)." 10/01/1975 - "Two cases are described of acute contact dermatitis from an antifungal cream, containing pyrrolnitrin, employed for the treatment of tinea cruris. "
5.	Tinea (Ringworm) 05/01/1967 - "[Therapy of trichophytosis by pyrrolnitrin preparations]." 02/08/2002 - "The UV irradiation of pyrrolnitrin (1a), which is an antibiotic clinically useful against dermatophytosis and possesses a unique 2-(pyrrol-3-yl)nitrobenzene moiety in the molecule, in an anhydrous aprotic solvent resulted in the exclusive formation of transient 7,4'-dichlorospiro[1,3-dihydrobenzo(c)isoxazole-3,3'-pyrrolin-2'-one] (2a) via the intramolecular oxidation of the juxtaposed pyrrole ring by the triplet-excited nitro group. "

Related Drugs and Biologics

1.	Solutions
2.	Miconazole (Monistat)
3.	Clotrimazole (Lotrimin)
4.	Ointments (Pastes)
5.	Biological Control Agents
6.	Solvents
7.	Soil
8.	Pyrroles
9.	Phenazines
10.	Isoxazoles

Related Therapies and Procedures

1.	Therapeutics