Diphosphates (Pyrophosphates)

03/01/2013 - "The objective of this eight week, single-center, two-cell, double-blind, and randomized clinical study was to evaluate the dentin hypersensitivity reduction efficacy of a mouthwash using Pro-Argin™ Mouthwash Technology containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride in an alcohol-free base ("Arginine Mouthwash") compared to an ordinary mouthwash without any active ingredients ("Negative Control"). "
03/01/2013 - "Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a negative control mouthwash on dentin hypersensitivity reduction. "
03/01/2013 - "Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a commercial mouthwash containing 2.4% potassium nitrate and 0.022% sodium fluoride and a control mouthwash containing 0.05% sodium fluoride on dentine hypersensitivity: a six-week randomized clinical study."

10/15/1970 - "[Remission of tumors under the influence of inorganic diphosphate]."
01/01/2021 - "Human Vγ9Vδ2 T cells recognize pyrophosphates produced by microbes and transformed cells and play a role in anti-infective immunity and tumor surveillance. "
01/01/2019 - "Background: Solitary lesions in the extremities showing 99mTc-methylene diphosphate (MDP) uptake are often encountered on whole-body bone scan (WBS), and proper interpretation of this diagnostic method is important for patients with known cancer. "
07/22/2011 - "Each of the four monophosphate analogues (including Z and E isomers) demonstrated in vitro cytotoxicity against selected human cancer cell lines comparable to their corresponding diphosphate congeners. "
09/01/1983 - "Uptake of technetium-99m methylene diphosphate (99mTc-MDP) by the primary tumor occurred in 20 of 27 cases, but correlation between tumor uptake and calcification was not statistically significant. "

11/01/1984 - "Fructose diphosphate has proved effective experimentally in ameliorating the effects of local and global ischemia of the heart. "
12/01/1986 - "Hemodynamics and metabolic effects of fructose 1-6 diphosphate in ischemia and shock--experimental and clinical observations."
04/01/2005 - "Polyadenosine diphosphate-ribose polymerase inhibition modulates skeletal muscle injury following ischemia reperfusion."
01/01/1997 - "A combined course of cytochrome C and fructose diphosphate also limited the size of the necrotic zone 72 h after transitory ischemia. "
07/01/1992 - "In separate groups of hearts, adenine nucleotide content (adenosine triphosphate, diphosphate, and monophosphate) was measured before ischemia, at end-ischemia, and 30 minutes after reperfusion. "

11/17/2020 - "Previous studies revealed the anticalculus activity of pyrophosphates, however there was no clinical study that evaluated microbiome changes associated with calculus inhibition. "
01/01/1995 - "Since dentifrices containing soluble pyrophosphates are known to significantly reduce calculus formation, this study was designed to investigate whether CHX-induced staining and increased calculus may be reduced by the use of such dentifrices. "
03/01/1988 - "[The effect of a dentifrice containing pyrophosphates on calculus accumulation]."
05/01/1985 - "In comparison with the control group, who used the sodium fluoride formula without the pyrophosphates, the test group had significantly less calculus by occurrence and severity. "
11/01/2020 - "During the last 50 years, an increasing number of toothpastes have been marketed that include pyrophosphates as anti-tartar (calculus) agents. "

04/01/2010 - "Bisphosphonates, synthetic pyrophosphate analogs, have shown promise in inhibiting bone resorption in human and animal trials. "
05/01/2014 - "Bisphosphonates, synthetic analogues to inorganic pyrophosphates found in the bone matrix, inhibit bone resorption. "
02/01/2014 - "Bisphosphonates are inorganic pyrophosphate analog which accumulate on the bone surface, cause osteoclast apoptosis, and inhibit bone resorption. "
11/01/2009 - "Bisphosphonates are synthetic analogs of naturally occurring pyrophosphates, and they inhibit osteoclast-mediated bone resorption. "
05/01/2007 - "Bisphosphonates are pyrophosphate analogs able to inhibit osteoclast-mediated bone resorption widely used in the treatment of diseases with high bone turnover. "