Pyrogens

Substances capable of increasing BODY TEMPERATURE and cause FEVER and may be used for FEVER THERAPY. They may be of microbial origin, often POLYSACCHARIDES, and may contaminate distilled water.

Networked: 229 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hartung, Thomas: 6 articles (01/2015 - 03/2005)
2.	Roth, Joachim: 4 articles (05/2009 - 06/2002)
3.	Hübschle, Thomas: 3 articles (05/2009 - 06/2002)
4.	Gerstberger, Rüdiger: 3 articles (05/2009 - 06/2002)
5.	Schindler, Stefanie: 3 articles (01/2009 - 03/2005)
6.	Daneshian, Mardas: 3 articles (01/2009 - 03/2005)
7.	von Aulock, Sonja: 3 articles (01/2009 - 03/2005)
8.	Souza, Glória E P: 2 articles (12/2011 - 02/2008)
9.	Wendel, Albrecht: 2 articles (07/2008 - 03/2005)
10.	Spreitzer, Ingo: 2 articles (10/2006 - 03/2005)

Related Diseases

1.	Fever (Fevers) 03/01/1990 - "The hypothesis that hypothalamic thermosensitive neurons play a major role in both normal thermoregulation and in fever production and lysis has particularly helped to advance our understanding of the neuronal mechanisms underlying the response to pyrogens. " 10/25/1991 - "Recent studies suggest that the organum vasculosum laminae terminalis (OVLT), which lacks the blood-brain barrier, may be necessary for fever induction by systemic pyrogens. " 01/01/1985 - "Central injection and lesion studies have shown that the brain, in particular the PO/AH, is the site of action of fever-inducing agents, termed pyrogens. " 06/01/1974 - "These studies demonstrate for the first time two chemically and biologically distinctive pyrogens derived from circulating human white blood cells and have important implications for our understanding of the pathogenesis of fever in man." 01/01/1960 - "Steroid fever studies: physiological differences between bacterial pyrogens and endogenous steroid pyrogens of man."
2.	Burns 09/01/1991 - "In children with burns in whom early pyrexia is common, central thermoregulation may also be affected by cytokine pyrogens. " 06/01/1999 - "Indomethacin eliminated the chronic increase in T(B) following burn injury, and this effect was not produced by changes in plasma levels of the endogenous pyrogens IL-1alpha and IL-6."
3.	Obstructive Lung Diseases (Obstructive Lung Disease) 01/01/2015 - "As the test can quantitatively assess human-relevant airborne pyrogens, the contribution of pyrogens to chronic obstructive lung diseases and childhood asthma can for the first time be defined and home and workplace safety improved in the future. "
4.	Asthma (Bronchial Asthma) 01/01/2015 - "As the test can quantitatively assess human-relevant airborne pyrogens, the contribution of pyrogens to chronic obstructive lung diseases and childhood asthma can for the first time be defined and home and workplace safety improved in the future. "
5.	Infection 01/01/1978 - "Thus, our analysis leads to the conclusion that the majority of the febrile reactions registered among the present patients were determined by endogenous factors such as infection, while exogenous factors such as dialysate bacteria and pyrogens seem to have played only a minor role." 09/01/1973 - "[Effect of bacterial and leukocytic pyrogens on the course of influenzal infection in rabbits]." 09/01/1948 - "A study of the relationship between the fever caused by bacterial pyrogens and the fever accompanying acute infections." 01/01/2004 - "Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed." 09/01/2003 - "Infection is the most common cause of fever, reflecting the effect of pyrogens on the hypothalamus. "

Related Drugs and Biologics

1.	Interleukin-6 (Interleukin 6)
2.	Indomethacin (Indometacin)
3.	Cytokines
4.	Interleukin-1 (Interleukin 1)
5.	Dinoprostone (PGE2)
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Interleukin-1beta (Interleukin 1 beta)
8.	Prostaglandins
9.	Antipyretics
10.	leukocyte endogenous mediator

Related Therapies and Procedures

1.	Intravenous Injections
2.	Injections
3.	Catheters
4.	Renal Dialysis (Hemodialysis)
5.	Bioreactors