Pyridoxic Acid

The catabolic product of most of VITAMIN B 6; (PYRIDOXINE; PYRIDOXAL; and PYRIDOXAMINE) which is excreted in the urine.

Also Known As:

4-Pyridoxic Acid; 4-Pyridoxinic Acid; 4-Pyridoxylic Acid; 4 Pyridoxic Acid; 4 Pyridoxinic Acid; 4 Pyridoxylic Acid; Pyridoxinecarboxylic Acid; 4-Pyridinecarboxylic acid, 3-hydroxy-5-(hydroxymethyl)-2-methyl-

Networked: 55 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Isonicotinic Acids: 144
      - Pyridoxic Acid: 55
        4-pyridoxic acid 5'-phosphate
        4-pyridoxic acid lactone
        pyridoxyl-histidine methyl ester
    - Picolinic Acids: 1
      - Pyridoxic Acid: 55
        4-pyridoxic acid 5'-phosphate
        4-pyridoxic acid lactone
        pyridoxyl-histidine methyl ester
- Heterocyclic Acids
  - Isonicotinic Acids: 144
    - Pyridoxic Acid: 55

Experts

1.	Midttun, Øivind: 5 articles (01/2020 - 06/2015)
2.	Ueland, Per M: 4 articles (01/2018 - 06/2015)
3.	Tell, Grethe S: 3 articles (01/2018 - 06/2015)
4.	Ulvik, Arve: 3 articles (01/2018 - 06/2015)
5.	Vollset, Stein E: 3 articles (01/2018 - 06/2015)
6.	Zuo, Hui: 3 articles (01/2018 - 06/2015)
7.	Chen, Jing: 2 articles (01/2022 - 01/2020)
8.	Kestenbaum, Bryan: 2 articles (01/2022 - 01/2020)
9.	Seliger, Stephen: 2 articles (01/2022 - 01/2020)
10.	Zelnick, Leila R: 2 articles (01/2022 - 01/2020)

Related Diseases

1.	Chronic Renal Insufficiency 12/01/2023 - "Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker-Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney Disease." 01/01/2023 - "The secretory clearance of 3 solutes (cinnamoylglycine, kynurenic acid, and pyridoxic acid) were on average 10%-15% lower among WLWH compared with those without HIV independent of eGFR, albuminuria and chronic kidney disease risk factors, including HCV, and injection drug use. "
2.	Albuminuria 01/01/2023 - "The secretory clearance of 3 solutes (cinnamoylglycine, kynurenic acid, and pyridoxic acid) were on average 10%-15% lower among WLWH compared with those without HIV independent of eGFR, albuminuria and chronic kidney disease risk factors, including HCV, and injection drug use. "
3.	Inflammation (Inflammations) 01/01/2005 - "Adjuvant arthritis in rats did not affect 4-pyridoxic acid excretion or muscle storage of pyridoxal 5'-phosphate, but it resulted in significantly lower pyridoxal 5'-phosphate levels in circulation and in liver during inflammation. " 03/01/1999 - "There was evidence that plasma pyridoxal phosphate was sensitive to metabolic conditions associated with inflammation and the acute-phase reaction, and that plasma pyridoxic acid was sensitive to renal function. " 01/01/2018 - "The PAr index, defined as the ratio 4-pyridoxic acid/(pyridoxal + PLP), reflects increased vitamin B6 catabolism during inflammation. " 01/01/2019 - "Increased vitamin B6 catabolism related to inflammation, as measured by the PAr index (the ratio of 4-pyridoxic acid over the sum of pyridoxal and pyridoxal-5'-phosphate), has been positively associated with lung cancer risk in two prospective European studies. " 06/15/2015 - "We recently proposed the ratio 3-hydroxykynurenine/xanthurenic acid (HK/XA) as an indicator of functional vitamin B6 status, and the 4-pyridoxic acid (PA) /(pyridoxal (PL) +PLP) ratio (PAr) as a marker of vitamin B6 catabolism during inflammation. "
4.	Weight Gain 01/01/2016 - "This study estimates associations between maternal vitamins B12, B6 (pyridoxal phosphate [PLP] and 4-pyridoxic acid [PA]), and homocysteine (Hcy) concentrations, offspring weight (birth weight and 3-year weight gain), and DNA methylation at four differentially methylated regions (DMRs) known to be involved in fetal growth and development (H19, MEG3, SGCE/PEG10, and PLAGL1). " 03/01/1999 - "Vitamin B-6 status was evaluated according to several biological criteria (weight gain, urinary excretion of xanthurenic acid after tryptophan loading, plasma pyridoxal 5'-phosphate, apparent pyridoxal 5'-phosphate-saturation of liver kynureninase, urinary excretion of 4-pyridoxic acid and fecal output of vitamin B-6). "
5.	Avitaminosis (Vitamin Deficiency) 01/01/1981 - "Flavine coenzymes have been found to promote more efficient normalization of pyridoxine and riboflavin balance in the body and to improve the general status of the animals, to increase the excretion of riboflavin and 4-pyridoxic acid with urine, to prove more rapid cure of vitamin deficiency." 09/01/1993 - "Alterations in metabolism of riboflavin did not involve the vitamin deficiency as shown by analysis of vitamins B6 and PP (4-pyridoxic acid and I-methyl nicotinamide, respectively) excretion with urine as well as by study of the coenzymes content in blood of healthy and sick children with various rates of riboflavin consumption. "

Related Drugs and Biologics

1.	Kynurenic Acid (Kynurenate)
2.	cinnamoylglycine
3.	Vitamins
4.	Pyridoxal
5.	Vitamin B 6
6.	Pyridoxal Phosphate (Pyridoxal 5 Phosphate)
7.	Riboflavin (Vitamin B2)
8.	Niacinamide (Nicotinamide)
9.	Creatinine
10.	Coenzymes (Enzyme Cofactors)

Related Therapies and Procedures

1.	Enzyme Replacement Therapy
2.	Therapeutics