Pyridoxamine

01/01/2012 - "Pyridoxamine ameliorates lipid peroxidation and insulin resistance in KK-Ay mice. "
02/01/2009 - "It appears that pyridoxamine ameliorated lipid peroxidation and insulin resistance in KK-A(y)/Ta mice. "
09/01/2010 - "Therefore, in this study, we examined whether pyridoxamine, an inhibitor of AGE formation could ameliorate insulin resistance in KK-A(y) mice, a model animal of obese, type 2 diabetes. "
01/01/2016 - "Delayed Intervention With Pyridoxamine Improves Metabolic Function and Prevents Adipose Tissue Inflammation and Insulin Resistance in High-Fat Diet-Induced Obese Mice."
09/01/2010 - "Pyridoxamine, an inhibitor of advanced glycation end product (AGE) formation ameliorates insulin resistance in obese, type 2 diabetic mice."

07/20/2015 - "Pyridoxamine (PM) is a prospective drug for the treatment of diabetic complications. "
02/01/2009 - "Pyridoxamine inhibits the development of diabetic complications. "
02/01/2009 - "Pleiotropic effect of pyridoxamine on diabetic complications via CD36 expression in KK-Ay/Ta mice."
10/01/2008 - "The AGE inhibitor pyridoxamine (PM) prevents irreversible protein glycation, thereby reducing various diabetic complications. "
11/01/2003 - "Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: a novel therapy for treatment of diabetic complications."

01/01/2012 - "Of note, pyridoxamine has also shown promise in the treatment of diabetic nephropathy if started early in the disease course. "
02/01/2009 - "The objective of the present study was to examine the pleiotropic effects of pyridoxamine, especially CD36 expression in KK-A(y)/Ta mice with type 2 diabetic nephropathy. "
04/01/2014 - "In this review, the authors explore pyridoxamine and other emerging therapeutic agents in the battle against diabetic nephropathy. "
01/01/2012 - "Pyridoxamine, advanced glycation inhibition, and diabetic nephropathy."
01/22/2008 - "Pyridoxamine (PM) is a promising drug candidate for treatment of diabetic nephropathy. "

01/01/2016 - "Pyridoxamine reduces postinjury fibrosis and improves functional recovery after acute kidney injury."
05/15/2022 - "This study was done to examine the effect of pyridoxamine against thioacetamide-induced hepatic fibrosis. "
01/01/2014 - "Cirrhosis associated with pyridoxal 5'-phosphate treatment of pyridoxamine 5'-phosphate oxidase deficiency."
07/01/2007 - "We demonstrate that although aminoguanidine, pyridoxamine, and BMP-7 significantly inhibit glomerular lesions, BMP-7 is most effective in the inhibition of tubular inflammation and tubulointerstitial fibrosis in these mice. "
02/01/2011 - "A number of novel therapeutic agents have also been tested in db/db mice, including inhibitors of inflammation (chemokine receptor antagonists, anti-CCL2 RNA aptamer, anti-c-fms antibody); oxidative stress (oxykine, biliverdin); the renin-angiotensin-aldosterone system (aliskiren, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, eplerenone); advanced glycation end products (AGE; pyridoxamine, alagebrium, soluble AGE receptor); angiogenesis (NM-3, anti-CXCL12 RNA aptamer, soluble Flt-1); lipid accumulation (statins, farnesoid X receptor agonists, Omacor); intracellular signaling pathways (PKC-β or JNK inhibitors); and fibrosis [transforming growth factor (TGF)-β antibody, TGF-βR kinase inhibitor, soluble betaglycan, SMP-534, CTGF-antisense oligonucleotide, mutant PAI-1, pirfenidone], which have identified potential therapeutic targets for clinical translation. "

01/01/2018 - "High-dose pyridoxamine add-on treatment was, in part, effective for a subpopulation of schizophrenia patients with enhanced carbonyl stress. "
01/01/2018 - "The aim of this clinical trial was to obtain proof of concept for high-dose pyridoxamine as a novel treatment for schizophrenia with enhanced carbonyl stress. "
01/01/2018 - "Pyridoxamine: A novel treatment for schizophrenia with enhanced carbonyl stress."
01/01/2018 - "Ten Japanese schizophrenia patients with high plasma pentosidine, which is a representative biomarker of enhanced carbonyl stress, were recruited in a 24-week, open trial in which high-dose pyridoxamine (ranging from 1200 to 2400 mg/day) was administered using a conventional antipsychotic regimen. "
01/01/2018 - "To explore the association between schizophrenia and six types of B vitamins, including choline, biotin, riboflavin, pyridoxamine, pyridoxine and nicotinamide, based on the hydrophilic interaction liquid chromatography column (HILIC) Liquid Chromatography-Mass Spectrometry (LC-MS) platform. "