Pyridoxal

The 4-carboxyaldehyde form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid.

Also Known As:

Networked: 249 relevant articles (8 outcomes, 31 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Selhub, Jacob: 10 articles (12/2013 - 11/2002)
2.	Cellini, Barbara: 7 articles (10/2015 - 11/2006)
3.	Huang, Yi-Chia: 7 articles (12/2014 - 07/2005)
4.	Clayton, Peter T: 6 articles (10/2015 - 04/2005)
5.	Oppici, Elisa: 5 articles (10/2015 - 01/2012)
6.	Downs, Diana M: 5 articles (04/2015 - 08/2013)
7.	Kato, Norihisa: 5 articles (05/2014 - 12/2003)
8.	Montioli, Riccardo: 5 articles (02/2014 - 11/2006)
9.	Mills, Philippa B: 4 articles (10/2015 - 04/2005)
10.	Midttun, Øivind: 4 articles (06/2015 - 08/2011)

Related Diseases

1.	Neoplasms (Cancer) 11/01/1993 - "Trials using immunocompromised animals indicated that although some qualitative differences may be detected between the control and experimental animals, tumor growth in these animals is so aggressive that multiple applications or higher concentrations of pyridoxal may be needed to obtain useful data." 10/18/2004 - "Pyridoxal phosphatase is a novel cancer autoantigen in the central nervous system." 01/01/1985 - "If tumors were first established in mice and then treated with pyridoxal for six days, a 39% reduction in tumor growth was observed. " 05/01/1984 - "Assays conducted without added pyridoxal 5'-phosphate revealed that the enzyme in microsomes isolated from the tumor was more readily depleted of this cofactor than was that in control microsomes; this phenomenon was most pronounced with the larger tumors. " 01/01/1985 - "In in vivo studies, mice pretreated with pyridoxal for two weeks and then injected with B16 melanoma cells had a 62% reduction in tumor weight compared with controls at the end of a three-week period. "
2.	Schizophrenia (Dementia Praecox) 11/01/2014 - "Pyridoxal levels were lower in schizophrenia and increased according to the clinical course of the illness. " 03/01/2011 - "As compared to that of the 61 control patients, 45 patients with schizophrenia yielded significantly high levels of AGEs in the plasma and low serum pyridoxal levels. " 01/01/2012 - "We found that seventeen schizophrenia (approximately 17.4%) showed increases in plasma pentosidine content although they have no physical complications, and concomitantly marked decrease of pyridoxal levels was found in schizophrenia. " 11/01/2014 - "Thus, extremely high pentosidine levels in a portion of patients may be caused by higher daily antipsychotic doses, whereas pyridoxal levels were lower in schizophrenia and increased according to the clinical course. " 09/01/2014 - "In June 2010, we reported on idiopathic carbonyl stress in a subpopulation of schizophrenia patients, leading to a failure of metabolic systems with plasma pentosidine accumulation and serum pyridoxal depletion. "
3.	Ischemia 06/14/2002 - "We studied potential protective effects of pyridoxal 5'-phosphate (PLP) and pyridoxal hydrochloride (pyridoxal) on the retinal neurons in a monkey model of transient global ischemia. " 07/01/2007 - "In the present study, we investigated ischemia-induced changes of pyridoxal 5'-phosphate synthesizing enzyme and degrading enzyme and neuroprotective effects and roles of pyridoxal 5'-phosphate against ischemic damage in the gerbil hippocampal CA1 region. " 07/01/2007 - "However, pyridoxal 5'-phosphate treatment into ischemic brains decreased GABA transaminase immunoreactivity in the CA1 region after ischemia. " 07/01/2007 - "Treatment with pyridoxal 5'-phosphate into brains (4 microg/5 microl, i.c.v.) at 30 min before transient ischemia protected about 80% of CA1 pyramidal cells 4 days after ischemia and induced elevation of glutamic acid decarboxylase 67 immunoreactivity in the CA1 region. " 01/01/2001 - "Neuroprotective effects of pyridoxal phosphate and pyridoxal against ischemia in monkeys."
4.	Body Weight (Weight, Body) 04/01/1989 - "The rats were injected with an i.v. bolus (125-200 mg Hb/kg body weight) of either 3H-labeled HbXL or noncross-linked pyridoxal 5'-phosphate modified Hb (diPLPHb) as a control. " 09/01/1995 - "Dietary supplementation significantly improved the concentrations of thiamin pyrophosphate and pyridoxal 5'-phosphate, increased body weight and decreased serum homocysteine concentration in the supplement group. " 05/01/1984 - "Azaserine at a dose of 10 mg/kg body weight which causes substantial DNA damage in normal rat pancreas, failed to induce DNA damage detectable by alkaline elution in the pancreas of pyridoxal-deficient rats. " 07/01/1989 - "Kittens fed a -PN diet had depressed body weight gain, food intake, plasma pyridoxal phosphate (PLP) and pyridoxal (PL), Hb and hematocrit, and had elevated urinary oxalate, plasma tyrosine and plasma cystathionine. " 01/01/1990 - "Plasma and erythrocyte pyridoxal levels increased by 118% and 117% respectively after 3 hours of aminophylline infusion, (4 mg/kg body weight/hour), however, infusion of beta-hydroxyethyltheophylline, which does not inhibit pyridoxal kinase, had no effect on either intra- or extracellular vitamin B6 aldehyde derivative levels. "
5.	Melanoma (Melanoma, Malignant) 11/01/1993 - "Efficacy of pyridoxal treatment in controlling the growth of melanomas in cell culture and an animal pilot study." 01/01/1983 - "These results indicate that pyridoxal and its metabolite, pyridoxal 5'-phosphate, may be involved in the growth regulation of a human malignant melanoma cell line." 01/01/1983 - "Experimentation revealed that the high-dose pyridoxal supplemented medium severely inhibited the growth of melanoma cells over a 72-hour growth period. " 01/01/1983 - "The in vitro growth characteristics of a human malignant melanoma cell line cultured in 0.5 mM pyridoxal supplemented medium were studied. " 01/01/1983 - "High-dose pyridoxal supplemented culture medium inhibits the growth of a human malignant melanoma cell line."

Related Drugs and Biologics

1.	Pyridoxine (Pyridoxin)
2.	Homocysteine
3.	Folic Acid (Vitamin M)
4.	pentosidine
5.	pimagedine (aminoguanidine)
6.	Erythrocyte Anion Exchange Protein 1 (Band 3 Protein)
7.	Vitamin B 6
8.	Messenger RNA (mRNA)
9.	Pyridoxal Phosphate (Pyridoxal 5 Phosphate)
10.	Theophylline (Theon)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Lasers (Laser)
4.	Intraperitoneal Injections
5.	Drug Therapy (Chemotherapy)