Pyrantel

A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920)

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Networked: 97 relevant articles (35 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mahabir, Sean P: 9 articles (07/2020 - 09/2019)
2.	Becskei, Csilla: 7 articles (07/2020 - 03/2020)
3.	Kryda, Kristina: 6 articles (03/2020 - 09/2019)
4.	Thys, Mirjan: 4 articles (03/2020 - 03/2020)
5.	Meyer, Leon: 3 articles (03/2020 - 03/2020)
6.	Martin, Richard J: 3 articles (07/2012 - 01/2010)
7.	Robertson, Alan P: 3 articles (07/2012 - 01/2010)
8.	Marchiondo, Alan A: 3 articles (06/2006 - 01/2005)
9.	Wozniakiewicz, Magda: 2 articles (07/2020 - 03/2020)
10.	Chapin, Sara: 2 articles (03/2020 - 09/2019)

Related Diseases

1.	Infections 03/01/1999 - "Statistical analysis of the pre-intervention faecal egg counts showed that there was a significant pre-treatment chance bias, despite randomization of subjects into treatment groups, arising from the main effect of sex (heavier infections among males) and a sex x treatment interaction (the sex bias was not evident in the pyrantel-treatment group). " 01/01/1999 - "Repetitive treatment with pyrantel failed to eradicate the ascarid infection. " 08/01/1995 - "On Day 25 post-infection, goats were randomized into an untreated control group and two pyrantel treatment groups (20 mg kg-1 bodyweight once, and 40 mg kg-1 bodyweight as two doses 24 h apart). " 02/01/1984 - "dubius by treatment with pyrantel 9, 11 and 15 days after infection with normal larvae did not restore the host's ability to respond to SRBC given on day 14. " 06/01/1979 - "4. The egg negative conversion rate and the egg reduction rate in the administration of pyrantel dry syrup at a single dose of 5 mg/kg body weight were 100% each in single infection of A. "
2.	Ascariasis 12/01/1980 - "Prophylactic medication with pyrantel to prevent liver condemnation in pigs naturally exposed to Ascaris infections." 01/01/1978 - "The best results were obtained using oxantel, either alone or in combination with pyrantel, at 15 to 20mg/kg. Only 2 of 152 patients with ascariasis were not cured after a single dose of pyrantel (given as oxantel-pyrantel) of 10, 15 or 20mg/kg, and both these patients were from the group given the lowest dose. " 03/01/1989 - "A multicentre, randomized trial was carried out to compare the efficacy of two single-dose treatments for ascariasis: mebendazole 200 mg, and pyrantel 10 mg/kg. Each centre enrolled 200 patients with a suspected diagnosis of ascariasis, 100 for each treatment, and the treatments were randomized for each centre. " 03/01/1989 - "Thus pyrantel was found to be significantly more efficacious than mebendazole for single-dose treatment of ascariasis." 08/01/1975 - "Comparison of pyrantel and tetramisole in ascariasis."
3.	Trichuriasis 01/01/1978 - "For trichuriasis, oxantel-pyrantel given twice, 12 hours apart, appears to be the best treatment schedule and further clinical trials using this regimen are suggested." 11/01/2002 - "Both drugs had a moderate efficacy against Trichuris trichiura infection, but pyrantel-oxantel had a higher cure rate (31.5% vs. 23.3%, P < 0.01), though the reductions in egg counts did not differ significantly and were more than 80%. " 10/03/1998 - "Randomised trial of albendazole and pyrantel in symptomless trichuriasis in children." 10/03/1998 - "Symptomless trichuriasis impairs growth and albendazole or pyrantel may affect growth, independently of a therapeutic action on parasites. " 01/01/1978 - "Against Trichuris infections, the average cure rate and egg reduction rate of oxantel-pyrantel treated groups was 87.5% and 92.3% respectively, and that for mebendazole was 65% and 89.1%. "
4.	Nematode Infections 01/01/1978 - "The combination, oxantel-pyrantel is a safe and effective treatment for multiple intestinal nematode infection." 11/01/2002 - "Evaluation of the efficacy of pyrantel-oxantel for the treatment of soil-transmitted nematode infections." 01/01/1978 - "Anthelminthic effect of oxantel and oxantel-pyrantel in intestinal nematode infections." 11/01/2002 - "A randomized controlled trial comparing the efficacy of pyrantel-oxantel (10 mg/kg) with mebendazole (500 mg) was performed on 1329 schoolchildren aged 6-9 years on Pemba Island in September-October 2000 to evaluate alternative single-dose drugs for regular treatment of intestinal nematode infections. " 11/01/2002 - "Pyrantel-oxantel (10 mg/kg) offers a valuable alternative to mebendazole as a single-dose treatment for the control of intestinal nematode infections in children in endemic areas of sub-Saharan Africa, due to its comparable efficacy, its low cost and its suitability for use in young children."
5.	Hookworm Infections (Hookworm Infection) 12/01/1997 - "duodenale is resistant to pyrantel and despite its relatively low cost and wide availability, should not be considered a drug of choice at this dose rate in the treatment of hookworm infections (A. " 12/01/1997 - "Failure of pyrantel in treatment of human hookworm infections (Ancylostoma duodenale) in the Kimberley region of north west Australia." 04/01/1984 - "Relative efficacy of mebendazole and pyrantel in hookworm infection. " 01/01/2018 - "We demonstrate that Cry5B strongly synergizes in vivo with both tribendimidine and pyrantel at specific dose ratios against hookworm infections. " 01/01/1990 - "[Effect of albendazole and pyrantel in treating intestinal helminthiasis and controlling the recurrence of hookworm infections]."

Related Drugs and Biologics

1.	Tablets
2.	moxidectin
3.	sarolaner
4.	oxantel
5.	Mebendazole (Anti-Worm)
6.	Ivermectin (Mectizan)
7.	Levamisole (Decaris)
8.	Anthelmintics
9.	Praziquantel (Biltricide)
10.	Pyrantel Pamoate (Pyrantel Embonate)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Therapeutics
3.	Duration of Therapy