Xanthogranulomatous Pyelonephritis

A chronic inflammatory condition of the KIDNEY resulting in diffuse renal destruction, a grossly enlarged and nonfunctioning kidney associated with NEPHROLITHIASIS and KIDNEY STONES.

Also Known As:

Networked: 96 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Malacoplakia
2.	Pyelonephritis
3.	Abscess
4.	Renal Cell Carcinoma (Grawitz Tumor)
5.	Carcinoma (Carcinomatosis)

Experts

1.	Schaeffer, Edward M: 2 articles (09/2012 - 11/2009)
2.	Wen, Y K: 2 articles (09/2008 - 12/2007)
3.	AlDarrab, Rakan M: 1 article (10/2015)
4.	AlAkrash, Hamad S: 1 article (10/2015)
5.	AlKhateeb, Sultan S: 1 article (10/2015)
6.	AlBqami, Nasser M: 1 article (10/2015)
7.	Jamil, Imran: 1 article (05/2014)
8.	Khawaja, Athar: 1 article (05/2014)
9.	Ahmed, Faizan: 1 article (05/2014)
10.	Shohab, Durre: 1 article (05/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Xanthogranulomatous Pyelonephritis:

1.	Anti-Bacterial Agents (Antibiotics)IBA 02/01/1996 - "A case of focal xanthogranulomatous pyelonephritis (XPN) in a child, successfully cured with antibiotics only, is presented, and this report is followed by a review of the literature on XPN in both children and adults. " 12/01/2001 - "We recommend the use of antibiotics as a first-line treatment for patients with focal xanthogranulomatous pyelonephritis." 06/01/2013 - "Initially, we diagnosed it as xanthogranulomatous pyelonephritis and treated it with antibiotics. " 12/01/2008 - "Xanthogranulomatous pyelonephritis successfully treated with antibiotics only." 09/01/2008 - "In addition to describing this unusual case, we provide a short review of xanthogranulomatous pyelonephritis successfully treated with antibiotics only."
2.	Megalocytic interstitial nephritisIBA 03/01/1981 - "The cases of megalocytic interstitial nephritis and xanthogranulomatous pyelonephritis represent the first reported electron-microscopic studies on human kidney of these diseases. " 12/01/1980 - "The pathologic findings and these immunologic studies are discussed in relation to xanthogranulomatous pyelonephritis and megalocytic interstitial nephritis and the pathogenesis of this disease." 03/01/1989 - "Histologic spectrum and its relationship to megalocytic interstitial nephritis and xanthogranulomatous pyelonephritis." 11/01/1998 - "Renal malacoplakia may be related to megalocytic interstitial nephritis and xanthogranulomatous pyelonephritis. " 03/01/1981 - "Light-microscopic and ultrastructural examinations of megalocytic interstitial nephritis, xanthogranulomatous pyelonephritis, and malakoplakia of the kidney were compared. "
3.	crystalloid solutionsIBA 03/01/1981 - "The study confirmed the presence of a polymorphous cellular infiltrate with predominate histiocytes containing crystalloid material in the case of megalocytic interstitial nephritis; a polymorphous cellular infiltrate with histiocytes predominating in the case of xanthogranulomatous pyelonephritis; and macrophages containing Michaelis-Gutmann bodies in the case of malakoplakia. "
4.	tebufenozide (Mimic)IBA 01/01/2002 - "Xanthogranulomatous pyelonephritis can mimic the clinical, cytological and imaging features of renal neoplasia." 07/01/1995 - "Like xanthogranulomatous pyelonephritis, it can clinically and radiologically mimic carcinoma. " 01/01/1995 - "Xanthogranulomatous pyelonephritis is a rare disease that may mimic various renal lesions, especially renal tumors, in its focal form. " 12/01/2011 - "Focal xanthogranulomatous pyelonephritis (XGP) is a chronic inflammatory condition that can mimic other disease conditions such as pyelonephritis, tuberculosis, renal abscess, renal cell carcinoma, and renal metastasis. "
5.	Carbon MonoxideIBA 10/01/2003 - "We report a case of co-existent massive renal replacement lipomatosis and xanthogranulomatous pyelonephritis." 10/01/2003 - "Co-existent massive renal replacement lipomatosis and xanthogranulomatous pyelonephritis--a case report." 02/15/2009 - "Indications for open surgery were complex stone burden of 297 cases, nephrectomy for non-functioning kidneys of 137 cases, with anatomical abnormalities of 134 cases, ESWL or endoscopy failure of 57 cases, with co-morbid medical diseases of 30 cases, with renal carcinoma of 5 cases, with xanthogranulomatous pyelonephritis of 3 cases, with kidney injury of 2 cases, and with other ipsilateral operation of 2 cases. "
6.	AntigensIBA 01/01/1981 - "Nine kidneys with typical xanthogranulomatous pyelonephritis (XP) involvement were investigated on the occurrence of bacteria, bacterial fragments and antigen, in light microscopy using Gram staining and immunohistochemistry, and by electron microscopy. " 03/01/1995 - "coli OK antigens, lysozyme and alpha-1-antichymotrypsin was useful in identifying the prediagnostic stage of malacoplakia and in differentiating the lesion from xanthogranulomatous pyelonephritis."
7.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 10/01/2007 - "Xanthogranulomatous pyelonephritis is associated with higher tissue expression of monocyte chemotactic protein-1."
8.	Muramidase (Lysozyme)IBA 03/01/1995 - "Antigenicity of lysozyme and alpha-1-antichymotrypsin on the von Hansemann cells was equivocal, but these enzymes were strongly positive on macrophages of xanthogranulomatous pyelonephritis. " 03/01/1995 - "coli OK antigens, lysozyme and alpha-1-antichymotrypsin was useful in identifying the prediagnostic stage of malacoplakia and in differentiating the lesion from xanthogranulomatous pyelonephritis."
9.	MucinsIBA 10/01/1987 - "Mucin secreting adenocarcinoma of pelvis with xanthogranulomatous pyelonephritis (a case report)."
10.	LipidsIBA 01/01/2006 - "Xanthogranulomatous pyelonephritis (XGP) is a rare entity characterized by the formation of inflammatory renal masses rich in macrophages loaded with lipids. "

Therapies and Procedures

1.	Nephrectomy 05/01/2014 - "The other kidney required nephrectomy for xanthogranulomatous pyelonephritis. " 01/01/2013 - "She was diagnosed as stage III Xanthogranulomatous pyelonephritis and managed with radical nephrectomy with favourable outcome. " 01/01/2013 - "The role of laparoscopic nephrectomy in pediatric xanthogranulomatous pyelonephritis: a case report." 09/01/2012 - "Re: Laparoscopic nephrectomy in xanthogranulomatous pyelonephritis: 7-year single-surgeon outcome. " 08/01/2012 - "Laparoscopic nephrectomy for the treatment of xanthogranulomatous pyelonephritis is feasible and associated with low levels of morbidity. "
2.	Homologous Transplantation (Allograft) 12/01/1997 - "Xanthogranulomatous pyelonephritis rarely occurs in renal allografts. " 12/01/1997 - "Xanthogranulomatous pyelonephritis in a renal allograft recipient." 07/01/1997 - "Xanthogranulomatous pyelonephritis caused by Surgical in a renal allograft." 07/01/1996 - "[Xanthogranulomatous pyelonephritis in renal allograft. " 01/01/1994 - "Xanthogranulomatous pyelonephritis in renal allografts: report of 2 cases."
3.	Transplants (Transplant) 12/01/2003 - "The reported case presents a febrile patient with a failing renal graft, in whom xanthogranulomatous pyelonephritis was established by histologic evaluation of transplantectomy specimens. " 01/01/2002 - "[Xanthogranulomatous pyelonephritis associated with pregnancy, in ex-transplant donor with single kidney]." 12/01/1997 - "Associated patient symptomology is nonspecific, and graft imaging with ultrasonography and computed tomography was not helpful as it would be with native kidney xanthogranulomatous pyelonephritis. " 01/01/1994 - "No graft was lost as a result of xanthogranulomatous pyelonephritis and no nephrectomy was required in either patient. " 04/01/2011 - "We describe a case of xanthogranulomatous pyelonephritis (XPN) in the native kidney in a patient of post transplant ADPKD which presented as frequently relapsing UTI with graft dysfunction where in accurate diagnosis was made possible with the aid of 18-fluorodeoxyglucose (FDG) - Positron emission computerized tomography (PET/CT)."
4.	Transplantation (Transplant Recipients) 04/01/1997 - "Xanthogranulomatous pyelonephritis in the native kidney of a renal transplant recipient." 01/01/1994 - "We report 2 cases of xanthogranulomatous pyelonephritis that occurred in renal transplant recipients. " 09/01/1992 - "An unusual case of a 44-year-old male renal transplant recipient who developed bilateral xanthogranulomatous pyelonephritis (XPN) of his native kidneys is presented. " 01/01/1984 - "Xanthogranulomatous pyelonephritis in renal transplant recipient." 09/01/1992 - "Bilateral xanthogranulomatous pyelonephritis involving native kidneys in a renal transplant recipient: association with renal cell carcinoma and amyloidosis."
5.	Ligation 08/01/2004 - "We report a case of SMA ligation during left nephrectomy for xanthogranulomatous pyelonephritis, review the intraoperative evaluation of suspected SMA injury, and describe our vascular repair using a vein patch from the native left renal vein."