An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE.
Also Known As:
Purpura, Thrombotic Thrombocytopenic; Congenital Thrombotic Thrombocytopenic Purpura; Familial Thrombotic Thrombocytopenic Purpura; Moschcowitz Disease; Schulman-Upshaw Syndrome; Disease, Moschcowitz; Disease, Moschkowitz; Purpuras, Thrombotic Thrombocytopenic; Purpuras, Thrombotic Thrombopenic; Schulman Upshaw Syndrome; Syndrome, Schulman-Upshaw; Thrombocytopenic Purpura, Thrombotic; Thrombocytopenic Purpuras, Thrombotic; Thrombopenic Purpura, Thrombotic; Thrombopenic Purpuras, Thrombotic; Thrombotic Thrombocytopenic Purpuras; Thrombotic Thrombopenic Purpura; Thrombotic Thrombopenic Purpuras; Moschkowitz Disease; Purpura, Thrombotic Thrombopenic; Thrombotic Thrombocytopenic Purpura, Congenital; Thrombotic Thrombocytopenic Purpura, Familial