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Schoenlein-Henoch Purpura (Purpura, Schoenlein Henoch)

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A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.

Also Known As:

Purpura, Schoenlein Henoch; Anaphylactoid Purpura; Nonthrombocytopenic Purpura; Allergic Purpura; Henoch Purpura; Purpura, Schoenlein-Henoch; Henoch Schonlein Purpura; Henoch-Schonlein Purpura; Purpura, Nonthrombopenic; Purpura, Schonlein-Henoch; Hemorrhagic Vasculitis; Hemorrhagica, Purpura; Henoch Schoenlein Purpura; Henoch Schonlein Purpuras; Henoch-Schonlein Purpuras; Nonthrombopenic Purpura; Nonthrombopenic Purpuras; Purpura, Allergic; Purpura, Anaphylactoid; Purpura, Henoch; Purpura, Henoch Schonlein; Purpura, Henoch-Schoenlein; Purpura, Henoch-Schonlein; Purpura, Rheumatoid; Purpura, Schonlein Henoch; Purpuras, Henoch Schonlein; Purpuras, Henoch-Schonlein; Purpuras, Nonthrombopenic; Purpuras, Schonlein-Henoch; Schoenlein Henoch Purpura; Schonlein Purpura, Henoch; Schonlein Purpuras, Henoch; Schonlein-Henoch Purpura; Schonlein-Henoch Purpuras; Henoch-Schoenlein Purpura; Purpura Hemorrhagica; Purpura, Nonthrombocytopenic; Rheumatoid Purpura; Vasculitis, Hemorrhagic

Networked: 486 relevant articles (12 outcomes, 26 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Nephritis
2.	Nephrotic Syndrome (Syndrome, Nephrotic)
3.	Infection
4.	Purpura
5.	Anti-Glomerular Basement Membrane Disease (Goodpasture's Syndrome)

Experts

1.	Shin, Jae Il: 5 articles (07/2014 - 06/2007)
2.	Lee, J S: 4 articles (01/2009 - 08/2000)
3.	Bo, Hu: 3 articles (03/2014 - 03/2012)
4.	Chen, Tao: 3 articles (12/2011 - 11/2009)
5.	Guo, Zai-Pei: 3 articles (12/2011 - 11/2009)
6.	Suyama, Kazuhide: 3 articles (04/2011 - 03/2007)
7.	Kawasaki, Yukihiko: 3 articles (04/2011 - 03/2007)
8.	Hashimoto, Koichi: 3 articles (04/2011 - 03/2007)
9.	Hosoya, Mitsuaki: 3 articles (04/2011 - 03/2007)
10.	Shin, J I: 3 articles (01/2009 - 08/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Schoenlein-Henoch Purpura:

1.	Methylprednisolone FDA LinkGeneric 10/01/2009 - "In this patient both Schönlein-Henoch purpura and gastrointestinal haemorrhage were successfully treated with intravenous methylprednisolone, avoiding surgical intervention. " 01/01/2007 - "[Complete remission of nephrotic syndrome with methylprednisolone pulses in an adult with Schönlein-Henoch purpura]." 04/01/1998 - "Between 1980 and 1994, 38 children with severe forms of Schönlein-Henoch purpura glomerulonephritis were entered into a prospective study to evaluate methylprednisolone pulse therapy on the outcome of nephropathy in terms of clinical symptoms and histopathological changes. " 04/01/1998 - "Methylprednisolone pulse therapy in the treatment of severe forms of Schönlein-Henoch purpura nephritis." 09/01/1995 - "[Successful treatment of rapidly progressive glomerulonephritis associated with Henoch-Schoenlein purpura with high doses of methylprednisolone]."
2.	Prednisone (Sone)FDA LinkGeneric 09/01/1993 - "Early prednisone treatment and nephropathy in anaphylactoid purpura." 02/01/1992 - "A prospective study was performed to verify whether early administration of prednisone could be useful in preventing the development of nephropathy in anaphylactoid purpura. " 02/01/1992 - "Effectiveness of early prednisone treatment in preventing the development of nephropathy in anaphylactoid purpura." 03/01/1989 - "[The effect of prednisone in the development of nephropathy in Schoenlein-Henoch purpura]." 01/20/1957 - "[Treatment of Schönlein-Henoch purpura; most rapid and durable cure in three cases treated with prednisone]."
3.	Azathioprine (Imuran)FDA LinkGeneric 01/01/1998 - "Response of crescentic Henoch-Schoenlein purpura nephritis to corticosteroid and azathioprine therapy." 03/01/2000 - "We also examined the efficacy of treatment with prednisone (1 to 2 mg/kg/d) and azathioprine (1 to 2 mg/kg/d) for severe Henoch-Schonlein purpura (HSP) nephritis. " 03/01/2000 - "Effective therapy for severe Henoch-Schonlein purpura nephritis with prednisone and azathioprine: a clinical and histopathologic study."
4.	NitrogenIBA 07/01/2009 - "The objective of this study is to compare serum and urine reactive nitrogen intermediates (RNI) and citrulline levels in children with Henoch-Schonlein purpura (HSP) during activity and remission. "
5.	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/01/2009 - "Serum and urine nitric oxide levels in children with Henoch-Schonlein purpura during activity and remission: a study from North India."
6.	CitrullineIBA 07/01/2009 - "The objective of this study is to compare serum and urine reactive nitrogen intermediates (RNI) and citrulline levels in children with Henoch-Schonlein purpura (HSP) during activity and remission. "
7.	bredinin (mizoribine)IBA 02/01/2010 - "Successful use of mizoribine to treat recurrent corticosteroid-resistant palpable purpura in a patient with henoch-schonlein purpura nephritis." 04/01/2011 - "Methylprednisolone pulse plus mizoribine in children with Henoch-Schoenlein purpura nephritis." 04/01/2011 - "We evaluated whether methylprednisolone and urokinase pulse therapy combined with mizoribine (MUPM) was effective in children with severe Henoch-Schoenlein purpura nephritis (HSPN). " 03/01/2007 - "We report here an 11-year-old boy with Henoch-Schoenlein purpura nephritis (HSPN) accompanied by recurrent purpura and persistent nephropathy despite conventional therapy such as prednisolone, methylprednisolone pulse therapy and immunosuppressive agent (Mizoribine). "
8.	Cyclosporine (Ciclosporin)FDA LinkGeneric 06/01/1998 - "Failure of cyclosporine A in controlling Schoenlein-Henoch purpura." 04/01/1997 - "Severe nephrotic syndrome in a patient with Schönlein-Henoch purpura: complete remission after cyclosporin A."
9.	Fosinopril (Monopril)FDA LinkGeneric 03/01/2009 - "[Efficacy of fosinopril on proteinuria in children with Henoch-Schonlein purpura nephritis]."
10.	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 04/01/2011 - "We evaluated whether methylprednisolone and urokinase pulse therapy combined with mizoribine (MUPM) was effective in children with severe Henoch-Schoenlein purpura nephritis (HSPN). "

Therapies and Procedures

1.	Plasma Exchange 01/01/1979 - "Plasma exchange as sole therapy was effective in patients with idiopathic anaphylactoid purpura and mixed cryoglobulinaemia, but not in one SLE patient with CIC. " 03/01/1987 - "[Treatment, by plasma exchange, of a severe digestive manifestation of rheumatoid purpura in an adult]." 04/28/1982 - "[Plasma exchange treatment in a patient with severe Schoenlein-Henoch purpura]." 10/01/2008 - "Successful treatment of Henoch-Schonlein purpura nephritis with plasma exchange in an adult male." 09/01/1981 - "Plasma exchange may be a useful form of therapy for patients with Henoch-Schoenlein purpura and progressive renal failure. "
2.	Plasmapheresis 09/01/1989 - "[Experience in the use of plasmapheresis in children with hemorrhagic vasculitis]." 03/01/2004 - "Successful treatment of crescentic glomerulonephritis associated with adult-onset Henoch-Schoenlein purpura by double-filtration plasmapheresis." 09/01/1981 - "Two adult patients with Henoch-Schoenlein purpura and rapidly progressive glomerulonephritis were treated with plasmapheresis. " 01/01/1988 - "In virus hepatitis with liver insufficiency, bullous erythema and hemorrhagic vasculitis plasmapheresis can be used as an independent method. " 01/01/1984 - "The authors discuss the results of the use of therapeutic plasmapheresis (290 sessions) in 56 patients with immunity-mediated diseases: hemorrhagic vasculitis, Goodpasture's syndrome, multiple sclerosis, Guillain-Barre's syndrome, rheumatoid arthritis, partial red cell aplasia, etc. Demonstrate the possibilities of the attainment of positive results provided plasmapheresis is included into the complex of therapeutic measures. "
3.	Renal Dialysis (Hemodialysis) 04/01/2006 - "A case of Henoch-Schonlein purpura temporarily improved by hemodialysis." 01/01/1996 - "[A case of acute renal failure in pregnancy complicated by Henoch-Schoenlein purpura requiring hemodialysis therapy]." 04/01/2006 - "We report a case of Henoch-Schonlein purpura that occurred in an adult patient with end-stage renal disease on continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis (HD). " 01/01/1998 - "A 54-year-old man on hemodialysis for acute chronic renal failure and on corticosteroids for Henoch-Schonlein purpura developed massive hematochezia. "
4.	Tonsillectomy 03/01/2002 - "To explore the peri-operative cure of patients suffered allergic purpura before tonsillectomy. " 03/01/2002 - "[The peri-operative cure of patients suffered allergic purpura before tonsillectomy]." 03/01/2007 - "Efficacy of tonsillectomy plus methylprednisolone pulse therapy for a child with Henoch-Schoenlein purpura nephritis."
5.	Transplants (Transplant) 01/01/2012 - "Post-transplant Henoch-Schonlein purpura de novo: clinical-histological discordance." 10/27/2011 - "Henoch-Schonlein Purpura nephropathy (HSPN) recurrence in renal transplant recipients (RTRs) has been reported in 35% of patients, leading in 11% of these patients to graft loss at 5 years. " 07/01/2011 - "Recurrence and graft loss after kidney transplantation for henoch-schonlein purpura nephritis: a multicenter analysis." 07/01/2001 - "We reported a case of Henoch-Schonlein Purpura in a 51-year-old male, on RRT for 20 years, 8 on dialysis and 12 with renal graft, because of ESRD of unknown origin (chronic glomerulonephritis?). " 05/15/1997 - "Long-term graft survival and graft function of renal transplant recipients with SLE, Wegener's granulomatosis, microscopic polyangiitis, Goodpasture's syndrome, and Henoch-Schonlein purpura were evaluated in a single center. "