Puromycin

A cinnamamido ADENOSINE found in STREPTOMYCES alboniger. It inhibits protein synthesis by binding to RNA. It is an antineoplastic and antitrypanosomal agent and is used in research as an inhibitor of protein synthesis.

Also Known As:

Networked: 398 relevant articles (12 outcomes, 31 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sun, Wei: 2 articles (11/2014 - 09/2012)
2.	Yao, Jian: 2 articles (11/2014 - 09/2012)
3.	Kim, Sung-Hoon: 2 articles (01/2013 - 05/2011)
4.	Tojo, Akihiro: 2 articles (01/2012 - 12/2011)
5.	Kinugasa, Satoshi: 2 articles (01/2012 - 12/2011)
6.	Øvervatn, Aud: 2 articles (04/2010 - 02/2009)
7.	Lamark, Trond: 2 articles (04/2010 - 02/2009)
8.	Bjørkøy, Geir: 2 articles (04/2010 - 02/2009)
9.	Johansen, Terje: 2 articles (04/2010 - 02/2009)
10.	Croons, Valerie: 2 articles (06/2009 - 06/2008)

Related Diseases

1.	Nephrotic Syndrome (Syndrome, Nephrotic) 12/01/2001 - "Results of our studies indicate that in contrast to puromycin induced nephrotic syndrome, diurnal rhythm of cholesterologenesis in CRF rats is preserved both in liver and in the intestine tissue. " 06/01/1997 - "In an attempt to address this possibility, gene expression of HL was studied in rats with puromycin-induced nephrotic syndrome (NS). " 08/01/1994 - "Puromycin-induced nephrotic syndrome is an animal model of progressive renal disease. " 01/01/1994 - "In the puromycin-induced nephrotic syndrome, the activity of one isoform is specifically enhanced. " 12/01/1991 - "Where do the experiments on rat kidneys exposed to puromycin leave us in attempting to evaluate further the pathophysiology of oedema in human nephrotic syndrome? "
2.	Amnesia (Dissociative Amnesia) 11/01/1985 - "At these later times, additional puromycin sites covering widespread forebrain areas are necessary to induce amnesia, a result that we attribute to the cerebral spread of the engram during the 6-day period. " 10/01/1984 - "At these later times, additional puromycin sites covering widespread areas of the forebrain are necessary to induce amnesia. " 05/01/1983 - "Temporal and pharmacological parameters of puromycin-induced amnesia." 04/01/1983 - "At these later times, additional puromycin injection sites covering widespread areas of the forebrain are necessary to induce amnesia. " 09/01/1981 - "Puromycin (PURO), which inhibited protein synthesis by about 70% during the training period, produced amnesia 5 hr after training, while acquisition was not affected. "
3.	Proteinuria 11/01/2007 - "In puromycin nephropathy in Wistar rats, IFN-beta started at induction of disease reduced proteinuria by up to 93%, but had no effect on glomerular histology. " 08/01/2007 - "Darbepoetin decreased the proteinuria of rats treated with puromycin. " 02/01/2005 - "The role of ILK signaling in podocyte damage was evaluated using puromycin, an agent known to cause selective proteinuria and to increase ILK activity. " 09/01/1996 - "In the glomeruli of Heymann nephritic rats, no similar changes were seen, suggesting that the sialylation defect is not due to proteinuria but is a consequence of targeted puromycin action on cells." 12/01/1995 - "In an attempt to examine the possible acute effect of PAN per se, experiments were repeated before and at short intervals (8 and 24 hr) after puromycin injection when proteinuria was absent and the drug exposure prominent. "
4.	Infection 11/01/1995 - "melitensis htrA mutant was significantly more sensitive (P < 0.001) to killing by H2O2 and puromycin than the parental strain, and a significant reduction (P < 0.001) in the number of RWP5 recovered from the spleens and livers of experimentally infected BALB/c mice was observed at one week post infection compared to 16M. " 07/01/1997 - "In this study, we have expressed a novel, selectable marker gene, puromycin acetyltransferase, under the control of the Drosophila melanogaster hsp 70 promoter or under the control of the AcMNPV ie-1 promoter which is active in Spodoptera frugiperda cells in the absence of virus infection. " 09/01/1955 - "Puromycin studies in experimental Trypanosoma gambiense and Trypanosoma rhodesiense infections in mice." 09/01/2015 - "The RAW264.7 cells with stable expression of RFP-GFP-LC3 were obtained by viral infection and puromycin screening. " 09/01/2015 - "The RAW264.7 cell strain with stable expression of RFP-GFP-LC3 was screened with puromycin and analyzed with flow cytometry and fluorescent microscopy for infection efficiency. "
5.	Nephrosis 11/01/1989 - "Essential fatty acid deficiency during acute puromycin nephrosis ameliorates late renal injury." 01/01/2006 - "CHOP was weakly expressed in podocytes of control kidneys but up-regulated in most proteinuric human kidneys and in rat puromycin nephrosis. " 10/01/2002 - "Inhibition of Na(+)-Ca(2+) exchange by puromycin may contribute to podocyte injury in PAN nephrosis." 08/01/2002 - "Acute puromycin nephrosis does not cause a notable reduction in visceral epithelial cell number. " 08/01/2002 - "Rats that recover from acute puromycin nephrosis later develop widespread glomerular and tubulointerstitial injury. "

Related Drugs and Biologics

1.	Arginine Vasopressin (Argipressin)
2.	Arginine (L-Arginine)
3.	Lypressin
4.	cyclo(leucylglycine)
5.	Puromycin Aminonucleoside
6.	Cycloheximide (Cicloheximide)
7.	Protein Synthesis Inhibitors
8.	Posterior Pituitary Hormones
9.	Verapamil (Calan)
10.	Nifedipine (Adalat)

Related Therapies and Procedures

1.	Injections
2.	Aftercare (After-Treatment)
3.	Nephrectomy
4.	Intravenous Injections
5.	Intraperitoneal Injections