Puromycin

A cinnamamido ADENOSINE found in STREPTOMYCES alboniger. It inhibits protein synthesis by binding to RNA. It is an antineoplastic and antitrypanosomal agent and is used in research as an inhibitor of protein synthesis.

Also Known As:

CL-13900; P-638; Puromycin Dihydrochloride; Puromycin Hydrochloride; Stylomycin; CL 13900; CL13900; P 638; P638; Adenosine, 3'-((2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyl-, (S)-

Networked: 486 relevant articles (16 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kim, Sung-Hoon: 4 articles (04/2019 - 05/2011)
2.	Tojo, Akihiro: 3 articles (12/2021 - 12/2011)
3.	Vaziri, Nosratola D: 3 articles (01/2021 - 05/2002)
4.	Jung, Ji Hoon: 3 articles (04/2019 - 01/2013)
5.	Kim, Bonglee: 3 articles (04/2019 - 01/2013)
6.	Akiyama, Saeko: 2 articles (12/2022 - 10/2022)
7.	Ite, Kenta: 2 articles (12/2022 - 10/2022)
8.	Kasahara, Mureo: 2 articles (12/2022 - 10/2022)
9.	Kimura, Tohru: 2 articles (12/2022 - 10/2022)
10.	Kiyono, Tohru: 2 articles (12/2022 - 10/2022)

Related Diseases

1.	Nephrotic Syndrome (Syndrome, Nephrotic) 12/01/2001 - "Results of our studies indicate that in contrast to puromycin induced nephrotic syndrome, diurnal rhythm of cholesterologenesis in CRF rats is preserved both in liver and in the intestine tissue. " 06/01/1997 - "In an attempt to address this possibility, gene expression of HL was studied in rats with puromycin-induced nephrotic syndrome (NS). " 08/01/1994 - "Puromycin-induced nephrotic syndrome is an animal model of progressive renal disease. " 12/01/1991 - "Where do the experiments on rat kidneys exposed to puromycin leave us in attempting to evaluate further the pathophysiology of oedema in human nephrotic syndrome? " 07/01/2000 - "Experimental nephrotic syndrome was induced in SD rats by repeated peritoneal injections of puromycin. "
2.	Proteinuria 01/01/2023 - "Puromycin treatment can cause glomerular injury to the kidney, leading to proteinuria. " 01/01/2021 - "Lastly, we found that MCC was downregulated in podocytes treated with puromycin aminonucleosides and in glomeruli of diabetic mice and FSGS patients, implicating MCC is involved in the development of podocytopathy and proteinuria. " 11/01/2007 - "In puromycin nephropathy in Wistar rats, IFN-beta started at induction of disease reduced proteinuria by up to 93%, but had no effect on glomerular histology. " 08/01/2007 - "Darbepoetin decreased the proteinuria of rats treated with puromycin. " 02/01/2005 - "The role of ILK signaling in podocyte damage was evaluated using puromycin, an agent known to cause selective proteinuria and to increase ILK activity. "
3.	Amnesia (Dissociative Amnesia) 11/01/1985 - "At these later times, additional puromycin sites covering widespread forebrain areas are necessary to induce amnesia, a result that we attribute to the cerebral spread of the engram during the 6-day period. " 10/01/1984 - "At these later times, additional puromycin sites covering widespread areas of the forebrain are necessary to induce amnesia. " 05/01/1983 - "Temporal and pharmacological parameters of puromycin-induced amnesia." 04/01/1983 - "At these later times, additional puromycin injection sites covering widespread areas of the forebrain are necessary to induce amnesia. " 09/01/1995 - "Bitemporal injections of puromycin consistently induce amnesia of aversive maze learning in mice when administered within 3 days of training. "
4.	Nephrosis 01/01/2006 - "CHOP was weakly expressed in podocytes of control kidneys but up-regulated in most proteinuric human kidneys and in rat puromycin nephrosis. " 10/01/2002 - "Inhibition of Na(+)-Ca(2+) exchange by puromycin may contribute to podocyte injury in PAN nephrosis." 08/01/2002 - "Acute puromycin nephrosis does not cause a notable reduction in visceral epithelial cell number. " 08/01/2002 - "Rats that recover from acute puromycin nephrosis later develop widespread glomerular and tubulointerstitial injury. " 08/01/2002 - "Renal structural abnormalities following recovery from acute puromycin nephrosis."
5.	Infections 11/01/1995 - "melitensis htrA mutant was significantly more sensitive (P < 0.001) to killing by H2O2 and puromycin than the parental strain, and a significant reduction (P < 0.001) in the number of RWP5 recovered from the spleens and livers of experimentally infected BALB/c mice was observed at one week post infection compared to 16M. " 09/01/1955 - "Puromycin studies in experimental Trypanosoma gambiense and Trypanosoma rhodesiense infections in mice." 12/21/2021 - "Seventy-six hours after infection, stable cells were obtained after treated with puromycin for 3 weeks. " 07/10/2018 - "Through infection of the cells with the retrovirus, stabled PPARγ or CDK5 knockdown cell lines were set up and screened by incubation with puromycin. " 07/01/2018 - "Following infection with lentivirus, the expression of DLL4 in the Eca109 cells could be stably silenced through screening with puromycin, which was confirmed by western blotting. "

Related Drugs and Biologics

1.	Puromycin Aminonucleoside
2.	Peptides (Polypeptides)
3.	Arginine Vasopressin (Argipressin)
4.	Arginine (L-Arginine)
5.	Lypressin
6.	cyclo(leucylglycine)
7.	Proteins (Proteins, Gene)
8.	Messenger RNA (mRNA)
9.	Posterior Pituitary Hormones
10.	Monoclonal Antibodies

Related Therapies and Procedures

1.	Therapeutics
2.	Punctures
3.	Injections
4.	Aftercare (After-Treatment)
5.	Intravenous Injections