Purines

A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.

Networked: 436 relevant articles (6 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Souza, Diogo O: 9 articles (11/2015 - 04/2004)
2.	Schmidt, André P: 9 articles (11/2015 - 04/2004)
3.	Carter, Nicola S: 5 articles (02/2014 - 03/2005)
4.	Esther, Charles R: 5 articles (02/2013 - 01/2008)
5.	Böhmer, Ana Elisa: 5 articles (02/2011 - 10/2008)
6.	Ullman, Buddy: 4 articles (10/2010 - 03/2005)
7.	Soares, Félix A: 3 articles (11/2015 - 04/2004)
8.	Souza, D O: 3 articles (03/2010 - 02/2000)
9.	Schmidt, A P: 3 articles (03/2010 - 05/2000)
10.	Elisabetsky, Elaine: 3 articles (02/2010 - 10/2008)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2013 - "Enantiospecific synthesis of heterocycles linked to purines: different apoptosis modulation of enantiomers in breast cancer cells." 12/01/2014 - "Given the emerging role of adenosine and other purines in tumor growth and metastasis, this study evaluated the effects of adenosine on the invasion of metastatic prostate and breast cancer cells. " 05/01/2003 - "Novel radiolabeled O(6)-benzylguanine (O(6)-BG) derivatives, 2-amino-6-O-[(11)C]-[(methoxymethyl)benzyloxy]-9-methyl purines ([(11)C]p-O(6)-AMMP, 1a; [(11)C]m-O(6)-AMMP, 1b; [(11)C]o-O(6)-AMMP, 1c), 2-amino-6-O-benzyloxy-9-[(11)C]-[(methoxycarbonyl)methyl]purine ([(11)C]ABMMP, 2), and 2-amino-6-O-benzyloxy-9-[(11)C]-[(4'-methoxycarbonyl)benzyl]purine ([(11)C]ABMBP, 3), have been synthesized for evaluation as new potential positron emission tomography (PET) imaging agents for the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT) in breast cancer. " 07/01/2012 - "Metabolomic fingerprint of breast cancer cells treated with the antidiabetic drug metformin revealed a significant accumulation of 5-formimino-tetrahydrofolate, one of the tetrahydrofolate forms carrying activated one-carbon units that are essential for the de novo synthesis of purines and pyrimidines. " 01/01/1999 - "This progress is manifested by new cytotoxic drugs which have recently entered clinical practice (taxanes, topoisomerase I inhibitors, gemcitabine, vinorelbine, new purines), as well as the efficacy of monoclonal antibody therapies against the CD-20 antigen of B-cell lymphomas and the Her2/neu oncogene in breast cancer. "
2.	Heart Failure 10/09/2013 - "Xanthine oxidase (XO) metabolizes purines to uric acid and its inhibition has been shown to improve clinical outcome in patients with chronic heart failure. " 11/16/1999 - "Progressive loss of myocardial ATP due to a loss of total purines during the development of heart failure in dogs: a compensatory role for the parallel loss of creatine." 09/01/2014 - "It further identifies areas where there is limited data, such as signaling systems 20-HETE, purines, endothelin, the role of renal water retention mechanisms for congestion, and renal hypoxia in AKI during heart failure. "
3.	Adenocarcinoma 06/01/1982 - "Quantitative structure-activity relationships of purines II: Prediction of activity against adenocarcinoma CA755 and toxicity in mice." 05/01/1982 - "A series of four human colon adenocarcinomas, growing as xenografts in immune-deprived mice, have been used to evaluate the efficacy of 5-FU in combination with two purines, hypoxanthine (Hx) and allopurinol (HPP), which have reduced the toxicity of 5-FU in host mice. "
4.	B-Cell Lymphoma (Lymphoma, B Cell) 01/01/1999 - "This progress is manifested by new cytotoxic drugs which have recently entered clinical practice (taxanes, topoisomerase I inhibitors, gemcitabine, vinorelbine, new purines), as well as the efficacy of monoclonal antibody therapies against the CD-20 antigen of B-cell lymphomas and the Her2/neu oncogene in breast cancer. "
5.	Chagas Disease (American Trypanosomiasis) 11/01/1988 - "Analogues of purines, especially those of hypoxanthine and inosine, appear to hold considerable promise for the treatment of Chagas' disease."

Related Drugs and Biologics

1.	Xanthine Oxidase
2.	Hypoxanthine
3.	Allopurinol (Remid)
4.	purine
5.	Inosine
6.	Uric Acid (Urate)
7.	Enzymes
8.	Fluorouracil (Carac)
9.	Dietary Proteins
10.	Topoisomerase I Inhibitors

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Tourniquets
3.	Ion-Selective Electrodes (Ion-Selective Electrode)
4.	Drug Therapy (Chemotherapy)
5.	Ketogenic Diet