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Pulmonary Valve Insufficiency (Insufficiency, Pulmonary Valve)

Subscribe to New Research on Pulmonary Valve Insufficiency

Backflow of blood from the PULMONARY ARTERY into the RIGHT VENTRICLE due to imperfect closure of the PULMONARY VALVE.

Also Known As:

Insufficiency, Pulmonary Valve; Incompetence, Pulmonary Valve; Pulmonary Valve Regurgitation; Regurgitation, Pulmonary; Regurgitation, Pulmonary Valve; Valve Incompetence, Pulmonary; Valve Insufficiency, Pulmonary; Valve Regurgitation, Pulmonary; Pulmonary Regurgitation; Pulmonary Valve Incompetence

Networked: 141 relevant articles (4 outcomes, 6 trials/studies)

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Disease Context: Research Results

Cardiovascular Diseases: 37259
- Heart Diseases: 18762
  - Heart Valve Diseases: 960
    - Pulmonary Valve Insufficiency: 141

Related Diseases

1.	Tetralogy of Fallot (Fallot Tetralogy)
2.	Atrial Heart Septal Defects (Atrial Septal Defect)
3.	Heartburn (Pyrosis)
4.	Deglutition Disorders (Dysphagia)
5.	Pulmonary Valve Stenosis (Pulmonary Stenosis)

Experts

1.	Bonhoeffer, Philipp: 6 articles (02/2011 - 04/2005)
2.	Khambadkone, Sachin: 5 articles (08/2011 - 04/2005)
3.	Taylor, Andrew M: 5 articles (02/2011 - 05/2006)
4.	McElhinney, Doff B: 4 articles (06/2015 - 03/2010)
5.	Lurz, Philipp: 4 articles (02/2011 - 09/2008)
6.	Nordmeyer, Johannes: 4 articles (02/2011 - 09/2008)
7.	Geva, Tal: 3 articles (04/2015 - 03/2010)
8.	Powell, Andrew J: 3 articles (04/2015 - 03/2010)
9.	Tan, Ru San: 3 articles (01/2014 - 11/2007)
10.	Tan, Ju Le: 3 articles (01/2014 - 11/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pulmonary Valve Insufficiency:

1.	OxygenIBA 06/01/1992 - "Patients with an abnormal maximal oxygen uptake (less than 85% of the predicted normal value) had significantly greater residual pulmonary regurgitation than those in whom oxygen uptake was normal. " 03/01/2015 - "Univariate logistic regression proved pulmonary regurgitation (OR = 3.57, 95% CI 1.27-10.04), VA (OR = 3.26, 95% CI 1.06-10.05), right ventricular end-diastolic enlargement (OR = 1.11, 95% CI 1.03-1.2), increase in VE/VCO2 slope (OR = 1.08, 95% CI 1.01-1.17), and decrease in peak oxygen uptake (OR = .91, 95% CI 0.83-0.99) to increase MTWA(abnormal) prevalence. " 04/01/2014 - "Stenting of the right ventricular outflow tract with valve sparing placement of the stent thus treating the underlying pathophysiology of the hypercyanotic spells provides a safe and effective management strategy, improving arterial oxygen saturation, avoiding pulmonary regurgitation and encouraging pulmonary artery growth. " 07/01/1990 - "Oxygen uptake at the anaerobic threshold (VO2AT) was in the normal range regardless of the existence of residual stenosis (PS) or pulmonary regurgitation (PR). " 05/01/1988 - "The 3 variables of pulmonary regurgitation, residual pulmonary stenosis, preoperative aortic oxygen saturation were statistically independent. "
2.	PeptidesIBA 08/01/2010 - "We conclude that in premature neonates with persistent arterial ducts; in teenagers with tetralogy of Fallot and pulmonary regurgitation; and in children with heart transplants and potential allograft rejection cardiac peptides can provide the clinician with additional information, but in children with atrial septal defects the peptides are not helpful in guiding treatment or follow-up."
3.	Protein Phosphatase 2 (Protein Phosphatase 2A)IBA 10/09/2013 - "In a time-course study of LT toxicity, echocardiography revealed acute diastolic heart failure accompanied by pulmonary regurgitation and left atrial dilation in adult Sprague-Dawley rats at time points corresponding to dysregulated JNK, phospholamban (PLB) and protein phosphatase 2A (PP2A) myocardial signaling. "
4.	Ramipril (Altace)FDA LinkGeneric 02/09/2012 - "Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation: the APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot)."
5.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 02/09/2012 - "Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation: the APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot)."
6.	dicarboxydine (DCD)IBA 02/01/2001 - "The purpose of this study was to validate a digital color Doppler (DCD) automated cardiac flow measurement method for quantifying pulmonary regurgitation (PR) in an in vitro and a chronic animal model of the right ventricular outflow tract of postoperative tetralogy of Fallot (TOF). "
7.	phospholambanIBA 10/09/2013 - "In a time-course study of LT toxicity, echocardiography revealed acute diastolic heart failure accompanied by pulmonary regurgitation and left atrial dilation in adult Sprague-Dawley rats at time points corresponding to dysregulated JNK, phospholamban (PLB) and protein phosphatase 2A (PP2A) myocardial signaling. "
8.	Dobutamine FDA LinkGeneric 12/01/2013 - "Eighteen adult patients (age 34 ± 13) with TOF and severe pulmonary regurgitation and 10 healthy volunteers underwent ventricular MR volumetry at baseline and during dobutamine infusion of 10 μg/kg/min and 20 μg/kg/min. Inter-observer and intra-observer agreement was calculated by coefficient of variance (COV). " 06/05/2013 - "To compare the ventricular response to dobutamine stress between adult patients with chronic pulmonary regurgitation (PR) after repair of tetralogy of Fallot (r-TOF) and healthy volunteers using a staged dobutamine stress MR (DS-MR) protocol. " 06/05/2013 - "Dobutamine stress MRI in repaired tetralogy of Fallot with chronic pulmonary regurgitation: a comparison with healthy volunteers." 06/01/2011 - "To evaluate the MR agreement of cardiac function parameters between volumetric (cine SSFP) and phase contrast flow (PC-flow) assessment in patients with repaired tetralogy of Fallot (r-TOF) and chronic pulmonary regurgitation (PR) at rest and under dobutamine stress (DS-MR). " 06/01/2006 - "The aims were to evaluate right and left ventricular systolic function and pulmonary regurgitation (PR) at rest and during dobutamine stress echocardiography (DSE) and to assess relationships between PR and cardiac haemodynamics in late postoperative tetralogy of Fallot patients. "
9.	pro-brain natriuretic peptide (1-76)IBA 07/01/2014 - "Tricuspid and pulmonary regurgitation peak velocities correlated with NT-proBNP (r = 0.305, p < 0.001 and r = 0.186, p = 0.045, respectively). " 07/01/2014 - "Moderate or severe pulmonary regurgitation was not associated with higher NT-proBNP. " 04/01/2009 - "Significant differences in NT-proBNP levels between children with severe pulmonary regurgitation and mild/moderate pulmonary regurgitation were detected (mean values at rest 18.6 +/- 15.0 vs. 4.2 +/- 3.9 fmol/l and after exertion 20.0 +/- 18.6 vs. 5.7 +/- 4.6 fmol/l) (p < 0.05). " 09/15/2011 - "Pulmonary valve replacement in chronic pulmonary regurgitation in adults with congenital heart disease: impact of preoperative QRS-duration and NT-proBNP levels on postoperative right ventricular function." 04/17/2009 - "To assess biventricular functional reserve (FR), NT-proBNP levels and exercise performance, in relation to right ventricular volume in patients with pulmonary regurgitation (PR) after repair of tetralogy of Fallot (TOF) at young age. "
10.	N 30IBA 09/14/2010 - "Between February 2004 and October 2008, 64 patients who underwent RV outflow tract procedures in early childhood had more than or equal to moderate pulmonary regurgitation, and fulfilled defined criteria for PVR were randomly assigned to undergo either PVR alone (n=34) or PVR with surgical RV remodeling (n=30). " 05/01/2000 - "Prevalence of pulmonary regurgitation in normal adult dogs (n=30) was established by color Doppler echocardiographic evaluation. " 02/08/2011 - "Patients were divided into 2 subgroups based on pre-procedural predominant pulmonary stenosis (PS) (n = 35) or predominant pulmonary regurgitation (PR) (n = 30). " 04/01/2003 - "Tricuspid regurgitation (TR) was most commonly found in 32.8% (n=57), pulmonary regurgitation (PR) in 17.2% (n=30), mitral regurgitation (MR) in 8.6% (n=15), and aortic regurgitation (AR) in 1.1% (n=2). "

Therapies and Procedures

1.	Stents 11/01/2010 - "The goal of this study was to evaluate the feasibility of percutaneous valve stent insertion to correct the pulmonary regurgitation in sheep using a cup-shaped valve stent. " 01/01/2015 - "Post-surgical conduit-free non-stenotic RVOT with free pulmonary regurgitation can be treated percutaneously with a valved stent if anatomical (predominantly size) criteria are met. " 08/01/2011 - "Stent embolization may occur particularly in patients with associated significant pulmonary regurgitation. " 11/01/2010 - "Percutaneous pulmonary valve stent implantation can reduce pulmonary regurgitation in a sheep model. " 11/01/2010 - "Percutaneous cylindrical stent insertion to induce significant pulmonary regurgitation in sheep was feasible, simple and reproducible. "
2.	Homologous Transplantation (Allograft) 09/01/2009 - "In a backward multivariate linear regression model, 'eccentric' pulmonary forward flow pattern (r(part) = 0.36, P < 0.001), 'homograft distortion angle' (r(part) = 0.31, P = 0.001), and pre-homograft RVOT diameter (r(part) = 0.19, P = 0.03) were independently associated with the degree of pulmonary regurgitation (in %) at 1 year. " 09/01/2008 - "To evaluate the effects on ventricular function and volumes following right ventricular outflow tract reconstruction (RVOTR) with pulmonary homograft replacement (PVR) and percutaneous pulmonary valve implantation (PPVI) for predominant pulmonary regurgitation. " 05/01/2008 - "Pulmonary regurgitation developed more frequently in homografts albeit at a longer duration of follow-up." 11/01/2007 - "Three patients required pulmonary valve homograft replacement for severe pulmonary regurgitation (PR) at 13, 28 and 36 years after the initial corrective operation. " 03/01/2006 - "We report a case of a 15 month-old boy who underwent the arterial switch operation using cryopreserved aortic homograft for transposition of the great arteries with pulmonary regurgitation, with coexisting right ventricular outflow tract obstruction precluding atrial switch operation. "
3.	Transplants (Transplant) 08/01/2007 - "The post operative course for these 11 years, she had been in controllable congestive heart failure from postoperative pulmonary regurgitation and myocardial ischemy owing to obstract of RCA graft." 09/01/1971 - "Pulmonary valve insufficiency in a case of tetralogy of Fallot after Brock's operation: correction by heterologous aortic graft." 08/01/2010 - "We conclude that in premature neonates with persistent arterial ducts; in teenagers with tetralogy of Fallot and pulmonary regurgitation; and in children with heart transplants and potential allograft rejection cardiac peptides can provide the clinician with additional information, but in children with atrial septal defects the peptides are not helpful in guiding treatment or follow-up."
4.	Fundoplication 12/01/2010 - "Significant reduction of all symptoms (heartburn, regurgitation, pulmonary symptoms, and dysphagia) was noted after fundoplication, except gas bloating (4.7 vs. 20.8%). "
5.	Balloon Dilation 07/01/2013 - "The impact of balloon to annulus ratio, age, and valve anatomy on the late development of moderate and severe pulmonary valve regurgitation following balloon valvuloplasty was analysed. " 12/01/2011 - "Despite application in patients with more hypoplastic valves, balloon valvuloplasty resulted in similar valve growth and pulmonary regurgitation as traditional methods, but higher rates of reintervention. " 11/01/2010 - "Pulmonary regurgitation often results from surgical or balloon valvuloplasty and is associated with deleterious long-term sequelae. " 03/09/2010 - "This study sought to examine the prevalence and predictors of pulmonary regurgitation (PR) following balloon dilation (BD) for pulmonary stenosis (PS) and to investigate its impact on ventricular volume and function, and exercise tolerance. " 07/01/2013 - "Pulmonary valve regurgitation following balloon valvuloplasty for moderate to severe pulmonary valve stenosis is a known late outcome of this procedure. "