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Ovine Pulmonary Adenomatosis (Jaagsiekte)

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A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.

Also Known As:

Jaagsiekte; Pulmonary Adenomatosis, Ovine; Adenomatosis, Ovine Pulmonary; Ovine Pulmonary Carcinoma; Pulmonary Ovine Adenomatosis; Adenomatoses, Ovine Pulmonary; Adenomatoses, Pulmonary Ovine; Adenomatosis, Pulmonary Ovine; Carcinomas, Ovine Pulmonary; Ovine Adenomatoses, Pulmonary; Ovine Adenomatosis, Pulmonary; Ovine Pulmonary Adenomatoses; Ovine Pulmonary Carcinomas; Pulmonary Adenomatoses, Ovine; Pulmonary Carcinoma, Ovine; Pulmonary Carcinomas, Ovine; Pulmonary Ovine Adenomatoses; Adenomatosis, Pulmonary, Ovine; Carcinoma, Ovine Pulmonary

Networked: 15 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Pulmonary Adenomatosis
2.	Carcinoma (Carcinomatosis)
3.	of Sheep Progressive Interstitial Pneumonia (Maedi)
4.	Neoplasms (Cancer)

Experts

1.	Sozmen, M: 1 article (11/2012)
2.	Beytut, E: 1 article (11/2012)
3.	Taylor, H W: 1 article (02/2002)
4.	Mitchell, M A: 1 article (02/2002)
5.	Kim, D Y: 1 article (02/2002)
6.	De las Heras, M: 1 article (02/2002)
7.	Cho, D-Y: 1 article (02/2002)
8.	de las Heras, M: 1 article (05/2001)
9.	Jassim, F A: 1 article (05/2001)
10.	Carlson, J O: 1 article (05/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ovine Pulmonary Adenomatosis:

1.	AntigensIBA 01/01/1988 - "These studies document the presence of type D-related retrovirus antigen in ovine pulmonary carcinoma (OPC) in the United States and indicate that lentivirus-induced LIP is a lesion frequently associated with this disease." 09/15/1992 - "Evidence for retroviral capsid and nucleocapsid antigens in ovine pulmonary carcinoma." 06/01/1986 - "Mason-Pfizer monkey virus-related antigen was detected in 3 out of 5 jaagsiekte lungs examined using a direct immunoperoxidase staining technique with anti-MPMV p27 serum. " 06/01/1986 - "The localization of a Mason-Pfizer monkey virus-related antigen in jaagsiekte tumour tissue and cell lines." 10/01/1990 - "A heterologous competition radioimmunoassay (RIA) which consisted of 125I-labeled langur retrovirus major gag protein and goat anti-squirrel monkey retrovirus serum was used to detect a type D retrovirus-associated antigen in tumor cell homogenates, lung fluid, and cell culture supernatant fluids of naturally occurring and experimentally-induced ovine pulmonary carcinoma (OPC, sheep pulmonary adenomatosis). "
2.	AntibodiesIBA 03/01/1979 - "On the other hand, the absence of antibodies in sheep sera from Iceland as well as the other data obtained in this study did not exclude involvement of the virus in jaagsiekte." 03/01/1979 - "Antibodies to herpesvirus ovis were present in roughly 70% of all animals tested and no evidence was obtained for the involvement of the virus in the aetiology of jaagsiekte. " 02/01/1979 - "Lung carcinoma of sheep (jaagsiekte): tissue-bound precipitating antibodies."
3.	Capsid Proteins (Capsid Protein)IBA 02/01/2002 - "In the present study, immunohistochemical examination of the pulmonary tumours with a rabbit polyclonal antiserum to jaagsiekte retroviral capsid protein proved negative."
4.	Pulmonary Surfactant-Associated Protein A (Surfactant Protein A)IBA 05/01/2001 - "Jaagsiekte sheep retrovirus proviral clone JSRV(JS7), derived from the JS7 lung tumor cell line, induces ovine pulmonary carcinoma and is integrated into the surfactant protein A gene."
5.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 11/01/2012 - "An investigation of growth factors and lactoferrin in naturally occurring ovine pulmonary adenomatosis."
6.	Conditioned Culture MediaIBA 06/01/1987 - "Demonstration of growth-inhibitory as well as growth-stimulatory factors in medium conditioned by lung lavage cells stimulated with a chemotactic factor secreted by jaagsiekte tumour cells."
7.	gag Gene Products (gag Protein)IBA 10/01/1990 - "Detection and quantitation of a type D retrovirus gag protein in ovine pulmonary carcinoma (sheep pulmonary adenomatosis) by means of a competition radioimmunoassay." 10/01/1990 - "A heterologous competition radioimmunoassay (RIA) which consisted of 125I-labeled langur retrovirus major gag protein and goat anti-squirrel monkey retrovirus serum was used to detect a type D retrovirus-associated antigen in tumor cell homogenates, lung fluid, and cell culture supernatant fluids of naturally occurring and experimentally-induced ovine pulmonary carcinoma (OPC, sheep pulmonary adenomatosis). "
8.	Tuberculin (PPD)IBA 09/01/1988 - "This effect, measured in terms of skin swelling after intradermal inoculation with tuberculin, showed a positive linear relationship with the latency period before the appearance of jaagsiekte symptoms in animals co-infected with JSRV, as well as with the activity of monocytes. "
9.	RNA (Ribonucleic Acid)IBA 01/01/1978 - "Lack of maedi viral related RNA in pulmonary carcinoma of sheep (jaagsiekte)."
10.	LactoferrinIBA 11/01/2012 - "An investigation of growth factors and lactoferrin in naturally occurring ovine pulmonary adenomatosis."

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 06/01/1980 - "A summary is given of the results obtained in experimental transmission of jaagsiekte by means transplantation of cell cultures. " 12/01/1977 - "Transplantation of cultured jaagsiekte (sheep pulmonary adenomatosis) cells into athymic nude mice."