Pteroylpolyglutamic Acids

Derivatives of folic acid (pteroylglutamic acid). In gamma-glutamyl linkage they are found in many tissues. They are converted to folic acid by the action of pteroylpolyglutamate hydrolase or synthesized from folic acid by the action of folate polyglutamate synthetase. Synthetic pteroylpolyglutamic acids, which are in alpha-glutamyl linkage, are active in bacterial growth assays.

Also Known As:

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fazili, Zia: 1 article (12/2005)
2.	Jain, Ram: 1 article (12/2005)
3.	Pfeiffer, Christine M: 1 article (12/2005)
4.	Zhang, Ming: 1 article (12/2005)
5.	Caldwell, J: 1 article (08/2005)
6.	Capps, R: 1 article (08/2005)
7.	Dervieux, T: 1 article (08/2005)
8.	Furst, D: 1 article (08/2005)
9.	Kremer, J: 1 article (08/2005)
10.	Lein, D O: 1 article (08/2005)

Related Diseases

1.	Folic Acid Deficiency (Folic Acid Deficiencies) 01/01/1983 - "[Effect of folic acid deficiency on the synthesis of pteroylpolyglutamates]." 01/01/1979 - "The distribution in liver of pteroylpolyglutamates and urinary excretion of folate metabolites was studied in folic acid deficient rats after injection of the vitamin, in order to evaluate the effect of folic acid deficiency on the conversion of the vitamin into actual coenzymic forms. " 01/01/1979 - "In view of role played by pteroylpolyglutamates as actual folate coenzymes in single-carbon unit metabolism, the effect of folic acid deficiency on the distribution of these compounds in rat liver has been studied. "
2.	Tropical Sprue 05/31/1969 - "Malabsorption of folate polyglutamates in tropical sprue." 05/31/1969 - "Malabsorption of folate polyglutamates prepared from yeast has been shown in eight patients with untreated tropical sprue and in three out of six patients receiving therapy for sprue. "
3.	Neural Tube Defects (Exencephaly) 05/01/1993 - "The ability to hydrolyse and absorb pteroylpolyglutamates (PteGlun) included in a standard meal in mothers who had given birth to an infant with a neural tube defect was tested by comparing them with mothers who had not had any infants with this defect. " 05/01/1993 - "Absorption of pteroylpolyglutamates in mothers of infants with neural tube defects."
4.	Leukemia 01/01/1983 - "Folate polyglutamates were poor substrates for the efflux mechanism for monoglutamates in L1210 mouse leukemia cells, with negligible loss of preformed folate polyglutamates to the medium over four hours. "
5.	Hypersensitivity (Allergy) 08/01/2000 - "A diet rich in natural folates (pteroylpolyglutamates) appears useful as a management strategy for providing adequate nutrition to patients with folic acid hypersensitivity."

Related Drugs and Biologics

1.	Folic Acid (Vitamin M)
2.	Methotrexate (Mexate)
3.	Glutamic Acid (Glutamate)
4.	Vitamins
5.	gamma-Glutamyl Hydrolase (Carboxypeptidase G2)
6.	Coenzymes (Enzyme Cofactors)
7.	Carbon

Related Therapies and Procedures

1.	Therapeutics