Psychosurgery (Lobotomy)

Treatment of chronic, severe and intractable psychiatric disorders by surgical removal or interruption of certain areas or pathways in the brain, especially in the prefrontal lobes.

Also Known As:

Networked: 605 relevant articles (19 outcomes, 35 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Lévêque, Marc: 5 articles (12/2019 - 01/2014)
2.	Miller, Jonathan P: 4 articles (01/2019 - 12/2015)
3.	Lipsman, Nir: 3 articles (01/2020 - 11/2013)
4.	Park, Jun T: 3 articles (08/2018 - 12/2015)
5.	Cosgrove, G Rees: 3 articles (01/2017 - 05/2002)
6.	Nijensohn, Daniel E: 3 articles (12/2015 - 09/2014)
7.	Durand, Edgar: 3 articles (01/2015 - 01/2014)
8.	Weil, Alexander G: 3 articles (01/2015 - 01/2014)
9.	Faria, Miguel A: 3 articles (01/2013 - 01/2013)
10.	Schulder, Michael: 2 articles (01/2022 - 01/2021)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/2013 - "Lobotomy was understood to be a promising treatment in schizophrenia and in 1940-ies and -50-ies about 1600 patients were operated in Finland. " 01/17/1970 - " leukotomy is a safe and effective method of reducing the symptoms of excessive tension, anxiety, fear or depression in patients with a variety of illnesses, including anxiety neurosis, phobic psychoneurosis, obsessional neurosis, neurotic or psychotic depressive reactions and schizophrenia. " 03/01/1953 - "[Psychopathological findings in a case of schizophrenia with clinical remission after Fiamberti leukotomy]." 12/15/2019 - "Since prefrontal leucotomy could be regarded as a model of sTBI, in this study we evaluated two autopsied schizophrenia with this procedure. " 01/01/2017 - "In this study, we analyzed postmortem brain tissues from five institutionalized patients with schizophrenia and history of surgical leucotomy with subsequent survival of at least another 40 years. "
2.	Mental Disorders (Mental Disorder) 02/01/2006 - "Neuroimaging, psychosurgery, deep-brain stimulation, and psychopharmacology hold considerable promise for more accurate prediction and diagnosis and more effective treatment of neurological and psychiatric disorders. " 01/01/2008 - "Authors suggest that stereotactic psychosurgery by RF and CKRS could be a safe and effective means of treating some medically intractable mental illnesses." 09/01/2002 - "These long-term results indicate that stereotactic psychosurgery is a safe and effective method of treating some medically intractable psychiatric illnesses." 03/01/2023 - "In this study the Contemporary role of Stereotactic radiosurgery is reviewed starting with relevant history of psychosurgery followed by individual psychiatric disorders." 07/01/2013 - "Existing data on efficacy and tolerability, as well as those studies indicating the risk for incapacity in drug-resistant severe mental disorders, suggest the need to achieve a better understanding of the capacity to consent to psychosurgery in patients affected by mental disorders. "
3.	Seizures (Absence Seizure) 01/01/1976 - "The seizures were relieved without the incapacitating complications that occur with standard lobotomy and temporal lobe resection. " 01/01/2013 - "The inception of the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (1974-1978) is briefly discussed as it pertains to the "determination of the Secretary of Health, Education and Welfare regarding the recommendations and guidelines on psychosurgery." The controversial work - namely recording of brain activity, DBS, and amygdalotomy for intractable psychomotor seizures in patients with uncontrolled violence - conducted by Drs. " 06/01/2004 - "To describe the technique of temporal lobotomy and demonstrate that it may produce results equivalent to anterior temporal lobectomy in the control of drug-resistant complex partial seizures of anterior temporal lobe origin. " 05/01/2002 - "The measures of the functional deficits carried out with the Wada test, associated with known brain lesions, aid in determining the lateralization of the onset of seizures and provide some estimate of the risk to memory after a temporal lobotomy. " 06/01/1998 - "Case report of a patient with complex partial frontal lobe seizures as a complication of bifrontal lobotomy."
4.	Epilepsy (Aura) 12/01/1999 - "Many investigations have been carried out on lateralization, mainly in relation to specific pathologies (i.e., epilepsy, split-brain, lobotomy, etc.), while there have been few studies of healthy subjects. " 07/01/1953 - "Lobotomy and epilepsy; a study of 1000 patients." 01/01/2023 - "Behavioral Improvements following Lesion Resection for Pediatric Epilepsy: Pediatric Psychosurgery?" 01/01/2023 - "Letter to the Editor regarding "Behavioral Improvements following Lesion Resection for Pediatric Epilepsy: Pediatric Psychosurgery?"" 01/01/2021 - "Penfield's greatest achievement - the surgical treatment of epilepsy - grew from the same roots as psychosurgery, and the histories of these treatments overlap in surprising ways. "
5.	Pain (Aches) 06/29/1946 - "Pain of organic disease relieved by prefrontal lobotomy." 01/01/1953 - "[Psychosurgery in inoperable pain; studies on 57 cases]." 03/01/1952 - "[Critical study on the treatment of pain with prefrontal lobotomy]." 11/01/2021 - "After categorizing the working mechanisms of each of the available treatments (pain killers, psychopharmacology, psychotherapy, neuromodulation, psychosurgery, spinal cord stimulation) to 1 or more of the 3 pathways, a rational combination can be proposed of activating the descending pain inhibitory pathway in combination with inhibition of the medial and lateral pathway, so as to rebalance the pain (and suffering) pathways." 12/01/2015 - "A final factor may be that Eva Perón's lobotomy was in fact performed for behavior and personality modification, and not just for pain control. "

Related Drugs and Biologics

1.	Anticonvulsants (Antiepileptic Drugs)
2.	Antidepressive Agents (Antidepressants)
3.	Serotonin (5 Hydroxytryptamine)
4.	Antipsychotic Agents (Antipsychotics)
5.	Psychotropic Drugs (Psychoactive Drugs)
6.	Pentylenetetrazole (Metrazol)
7.	Penicillins (Penicillin)
8.	Opioid Analgesics (Opioids)
9.	neodymium pyrocatechin disulfonate (NPD)
10.	barbituric acid (barbiturate)

Related Therapies and Procedures

1.	Therapeutics
2.	Colostomy
3.	Deep Brain Stimulation
4.	Radiotherapy
5.	Adjuvant Chemotherapy