Psychosurgery (Lobotomy)

Treatment of chronic, severe and intractable psychiatric disorders by surgical removal or interruption of certain areas or pathways in the brain, especially in the prefrontal lobes.

Also Known As:

Networked: 457 relevant articles (12 outcomes, 28 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Nijensohn, Daniel E: 3 articles (12/2015 - 09/2014)
2.	Weil, Alexander G: 3 articles (01/2015 - 01/2014)
3.	Lévêque, Marc: 3 articles (01/2015 - 01/2014)
4.	Durand, Edgar: 3 articles (01/2015 - 01/2014)
5.	Dougherty, Darin D: 2 articles (01/2014 - 05/2002)
6.	Cosgrove, G Rees: 2 articles (09/2011 - 05/2002)
7.	Smith, Timothy R: 1 article (12/2015)
8.	Laws, Edward R: 1 article (12/2015)
9.	Bi, Wenya Linda: 1 article (12/2015)
10.	Brewster, Ryan: 1 article (12/2015)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/2013 - "Lobotomy was understood to be a promising treatment in schizophrenia and in 1940-ies and -50-ies about 1600 patients were operated in Finland. " 01/17/1970 - " leukotomy is a safe and effective method of reducing the symptoms of excessive tension, anxiety, fear or depression in patients with a variety of illnesses, including anxiety neurosis, phobic psychoneurosis, obsessional neurosis, neurotic or psychotic depressive reactions and schizophrenia. " 03/01/1953 - "[Psychopathological findings in a case of schizophrenia with clinical remission after Fiamberti leukotomy]." 01/01/2013 - "Well designed controlled trials are needed to establish the effectiveness of psychosurgery in patients with schizophrenia." 08/01/2004 - "This study investigated the long-term effects of bilateral prefrontal leukotomy on lexical abilities in schizophrenia subjects. "
2.	Pain (Aches) 03/01/2006 - "Following prefrontal lobotomy, the emotional impact of chronic pain is dramatically reduced, while affective responses to acute pain are paradoxically increased. " 06/29/1946 - "Pain of organic disease relieved by prefrontal lobotomy." 01/01/1953 - "[Psychosurgery in inoperable pain; studies on 57 cases]." 03/01/1952 - "[Critical study on the treatment of pain with prefrontal lobotomy]." 12/01/2015 - "A final factor may be that Eva Perón's lobotomy was in fact performed for behavior and personality modification, and not just for pain control. "
3.	Epilepsy (Aura) 12/01/1999 - "Many investigations have been carried out on lateralization, mainly in relation to specific pathologies (i.e., epilepsy, split-brain, lobotomy, etc.), while there have been few studies of healthy subjects. " 07/01/1953 - "Lobotomy and epilepsy; a study of 1000 patients." 12/01/2010 - "The mean post-operative CRP levels were highest in the most surgically traumatic procedure--lobotomy for epilepsy intervention, and lowest in the least surgically traumatic procedure--stereotactic brain biopsy (p < 0.001). " 06/01/2004 - "Temporal lobotomy in the surgical management of epilepsy: technical report." 05/01/2002 - "In order to improve the refractory epilepsy the team decided an epilepsy surgery with right temporal lobotomy and right frontal corticetomy. "
4.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 04/01/1992 - "Except for rarely performed psychosurgery, obsessive compulsive disorder seldom improved with reversible treatments before 1966. " 01/01/2001 - "The object of this study is to assess the changes in regional cerebral blood flow (rCBF) following stereotactic limbic leukotomy in patients with medically intractable Obsessive-Compulsive Disorder (OCD). " 07/01/2015 - "Surgical therapies for treatment-refractory obsessive-compulsive disorder (OCD), such as deep brain stimulation or psychosurgery, remain unattainable for many patients. " 05/01/2014 - "Over the past decade the clinical applications have expanded into the realm of psychosurgery, including depression and obsessive compulsive disorder (OCD). " 01/01/2014 - "The pilot study correlated cingulotomy and limbic leucotomy lesion characteristics with clinical outcomes for patients with obsessive-compulsive disorder. "
5.	Seizures (Seizure) 09/01/2013 - "Postoperatively, one of two patients with temporal lobectomy and one of three patients with topectomy were seizure-free at 1-year follow-up. " 01/01/2013 - "The inception of the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (1974-1978) is briefly discussed as it pertains to the "determination of the Secretary of Health, Education and Welfare regarding the recommendations and guidelines on psychosurgery." The controversial work - namely recording of brain activity, DBS, and amygdalotomy for intractable psychomotor seizures in patients with uncontrolled violence - conducted by Drs. " 01/01/2013 - "Violence, mental illness, and the brain - A brief history of psychosurgery: Part 3 - From deep brain stimulation to amygdalotomy for violent behavior, seizures, and pathological aggression in humans." 03/01/2012 - "Circumscribed occipital topectomy led to seizure freedom. " 06/01/2009 - "Lesionectomy resulted in the best seizure control, followed by topectomy, and then MSTs."

Related Drugs and Biologics

1.	Antipsychotic Agents (Antipsychotics)
2.	Penicillins (Penicillin)
3.	phenothiazine
4.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)
5.	Neurotransmitter Agents (Neurotransmitter)
6.	Vanadium
7.	Titanium
8.	Prolactin
9.	Procaine (Novocaine)
10.	Placebos

Related Therapies and Procedures

1.	Colostomy
2.	Psychosurgery (Lobotomy)
3.	Drug Therapy (Chemotherapy)
4.	Split-Brain Procedure (Split-Brain)
5.	Deep Brain Stimulation