HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Psychomotor Disorders

Subscribe to New Research on Psychomotor Disorders

Abnormalities of motor function that are associated with organic and non-organic cognitive disorders.

Also Known As:

Developmental Psychomotor Disorders; Psychomotor Disorders, Developmental; Developmental Psychomotor Disorder; Impairment, Psychomotor; Impairments, Psychomotor; Psychomotor Disorder, Developmental; Psychomotor Impairments; Psychomotor Impairment

Networked: 177 relevant articles (4 outcomes, 18 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Amnesia (Dissociative Amnesia)
2.	Perennial Allergic Rhinitis
3.	Seasonal Allergic Rhinitis (Hay Fever)
4.	Sleep Initiation and Maintenance Disorders (Insomnia)
5.	Anterograde Amnesia

Experts

1.	Zacny, James P: 6 articles (01/2012 - 01/2003)
2.	Mørland, Jørg: 4 articles (05/2012 - 06/2006)
3.	Bramness, Jørgen G: 3 articles (11/2009 - 06/2006)
4.	Parrott, Andrew C: 2 articles (03/2014 - 07/2013)
5.	Hjelmeland, Knut: 2 articles (05/2012 - 08/2011)
6.	Gustavsen, Ingebjørg: 2 articles (05/2012 - 08/2011)
7.	Gutierrez, Sandra: 2 articles (05/2008 - 11/2003)
8.	Skurtveit, Svetlana: 2 articles (09/2007 - 06/2006)
9.	Herrmann, Nathan: 2 articles (11/2005 - 06/2003)
10.	Sproule, Beth A: 2 articles (11/2005 - 06/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Psychomotor Disorders:

1.	Diazepam (Valium)FDA LinkGeneric 08/01/1984 - "In the single dose study its effects were similar to diazepam for sedative action and most of the psychological tests, with a tendency towards greater psychomotor impairment. " 08/01/2007 - "Dissociation between objective psychomotor impairment and subjective sleepiness after diazepam administration in the aged people." 06/01/1996 - "Psychomotor impairment after 6 weeks of diazepam was similar to that seen in nonanxious volunteers." 02/01/1992 - "By 5 h after injection, 0.3 mg/kg of diazepam showed the highest scores of psychomotor impairment. " 04/01/1978 - "A technique for investigating the intensity and duration of human psychomotor impairment after intravenous diazepam."
2.	BenzodiazepinesIBA 10/01/1995 - "In cases where a benzodiazepine eliminated by oxidative metabolism is required, a reduction in initial dosage and careful clinical evaluation for signs of psychomotor impairment may be appropriate." 01/01/2014 - "They are associated with less drowsiness, psychomotor impairment, alcohol potentiation and potential for addiction or abuse than benzodiazepines. " 01/01/2006 - "Patients receiving benzodiazepines are at increased risk of daytime sedation, falls, and cognitive and psychomotor impairment. " 07/01/2004 - "The speed with which high-potency benzodiazepines are absorbed, and rise to peak concentrations is correlated with both abuse potential and with the incidence and severity of common adverse events, such as sedation and cognitive and psychomotor impairment. " 08/01/2003 - "Benzodiazepines are not recommended for long-term treatment of GAD, due to associated development of tolerance, psychomotor impairment, cognitive and memory changes, physical dependence, and a withdrawal reaction on discontinuation. "
3.	Flumazenil (Romazicon)FDA LinkGeneric 11/01/1992 - "Flumazenil (mean dose: 0.73 mg [7.3 ml]) was significantly more effective than placebo (mean dose: 8.9 ml) in reversing sedation, psychomotor impairment, and amnesia within 5 minutes after the start of administration. " 01/01/1990 - "Flumazenil reversed the psychomotor impairments induced by midazolam but not its amnesic effects. " 09/01/2002 - "Results indicate that within 20 min of administration, oral flumazenil is capable of partially reversing some cognitive and psychomotor impairments but the attentional and stimulus discrimination effects of midazolam sedation still remain." 10/01/1996 - "These results demonstrate that flumazenil's effects on reversing psychomotor impairment are similar when midazolam or diazepam are used for conscious sedation. " 10/01/1996 - "Flumazenil reversal of psychomotor impairment due to midazolam or diazepam for conscious sedation for upper endoscopy."
4.	Terfenadine (Seldane)IBA 04/01/1993 - "while several of the newer antihistamines, such as terfenadine, have overcome the problem of sedation, it is also important to establish their propensity to cause psychomotor impairment. " 01/01/1982 - "Clinically, terfenadine is effective against perennial allergic rhinitis, acute seasonal allergic rhinitis and allergic skin conditions while being devoid of CNS effects including sedation, psychomotor impairment or interaction with diazepam or alcohol. "
5.	Verapamil (Calan)FDA LinkGeneric 04/01/1992 - "Verapamil appears to be an effective hypotensive and does not produce profound psychomotor impairment at clinically used doses during the first weeks of treatment."
6.	Ethanol (Ethyl Alcohol)IBA 09/10/2013 - "Attempting to drive with a BAC above 0.4 g% verifies the development of an appreciable tolerance to ethanol-induced cognitive and psychomotor impairment. " 05/01/2001 - "Taken together, results suggest that prolonged voluntary ethanol intake could induce permanent psychomotor impairment and associative learning facilitation, and also an impairment of the inhibition related to the intoxication state." 01/01/1985 - "This paper reviews animal and human studies bearing on its relative abuse liability, including data on pharmacological profile, reinforcing effects, liking, speed of onset, discriminative stimulus effects, subjective effects, physiological dependence, rebound and early morning insomnia, drug produced anxiety, lethality in overdose, psychomotor impairment, interactions with ethanol, anterograde amnesia, impaired awareness of drug effect, and other psychiatric and behavioral disturbances. " 05/01/2012 - "Individual psychomotor impairment in relation to zopiclone and ethanol concentrations in blood--a randomized controlled double-blinded trial." 10/01/1980 - "Ethanol may enhance the sedative effect of benzodiazepines leading to greater psychomotor impairment, but the mechanism is not clear. "
7.	Nitrazepam (Serenade)IBA 01/01/1992 - "The concentration of nitrazepam increased gradually during the course of treatment and was associated with residual sedative effects on days 4 and 7. Nitrazepam produced no apparent psychomotor impairments in these studies. " 11/01/1980 - "On the morning after a hypnotic dose some residual psychomotor impairment does occur, which is comparable to that with usual doses of nitrazepam or flurazepam, but clinically apparent 'hangover' occurs infrequently. " 10/01/1987 - "This study examined psychomotor impairment in healthy young males and females after 1 and 7 nights of flunitrazepam (1 mg), nitrazepam (2.5 mg) and temazepam (10 mg). "
8.	Lorazepam (Ativan)FDA LinkGeneric 05/01/1985 - "After each pretreatment, psychomotor impairment by the challenge dose of lorazepam 3 mg (LZ) was measured. " 01/01/1993 - "The results of this study suggest that CL284,846 is a safe, rapid acting and effective sedative with some clear advantages over lorazepam with respect to unwanted cognitive and psychomotor impairments." 11/01/2003 - "Cognitive and psychomotor impairment were obtained with the higher doses of oxycodone, but to a much lesser degree than that of lorazepam. " 10/01/1995 - "There were no differences in psychomotor impairment, memory, sedation, or lorazepam concentration detected between the lorazepam alone and lorazepam plus nefazodone treatments. " 10/01/1995 - "By day 7 of alprazolam or lorazepam, psychomotor impairment decreased, indicating the development of tolerance. "
9.	Flunitrazepam (Rohypnol)IBA 06/02/2006 - "Flunitrazepam: psychomotor impairment, agitation and paradoxical reactions." 10/01/1999 - "Benzodiazepines in Miami-Dade County, Florida driving under the influence (DUI) cases (1995-1998) with emphasis on Rohypnol: GC-MS confirmation, patterns of use, psychomotor impairment, and results of Florida legislation." 01/01/1994 - "Flunitrazepam (1 and 2 mg), diazepam (10 and 20 mg) or placebo was administered to healthy, male volunteers, and the time course of psychomotor impairment, as indicated by simple and complex choice reaction time and movement time, was studied during a period of 6 h after drug intake. " 01/01/1994 - "This finding may indicate that flunitrazepam may have a higher apparent in vivo intrinsic efficacy than diazepam when assessed by psychomotor impairment." 10/01/1987 - "This study examined psychomotor impairment in healthy young males and females after 1 and 7 nights of flunitrazepam (1 mg), nitrazepam (2.5 mg) and temazepam (10 mg). "
10.	Alprazolam (Xanax)FDA LinkGeneric 01/01/1990 - "In addition, the study was designed to determine alprazolam pharmacokinetics and the degree to which its hydroxymetabolites accumulate, the degree of psychomotor impairment, and whether tolerance to impairment and sedation develops during three different multiple dose regimens. " 01/01/1987 - "Sedation and psychomotor impairment on day 1 were greatest with 2 mg alprazolam bid. " 09/01/2007 - "Pregabalin showed less cognitive and psychomotor impairment than alprazolam, and it showed different effects on sleep architecture to the latter in terms of REM sleep latency and slow wave stage 3/4 sleep. " 04/01/1999 - "Another objective was to determine whether DHEA-S and/or DHEA concentrations are related to psychomotor impairment after alprazolam. " 10/01/1995 - "Alprazolam plus nefazodone increased psychomotor impairment (MaxOE, approximately 50%) and sedation relative to alprazolam alone on days 3, 5, and 7 (p < 0.05). "

Therapies and Procedures

1.	Activities of Daily Living (ADL) 11/01/2000 - "Cross-sectional evaluation of the relationship of specific cognitive impairments, psychomotor retardation, severity of depression, and medical burden to impairment of instrumental activities of daily living. " 01/01/2012 - "Among psychomotor disorders in children, developmental coordination disorder (DCD) is characterized by a motor skill impairment that interferes with psychomotor development, academic performance and activities of daily living, despite normal intelligence. " 01/01/2008 - "Particular common features include cognitive deficits (attention, executive functioning, language and memory), functional difficulties (in activities of daily living), psychomotor impairment (dyspraxia and poor co-ordination), and behavioural difficulties (aggression, agitation, and wandering). "
2.	Preoperative Period 08/01/2000 - "Patients in the three midazolam groups experienced significant psychomotor impairment in the preoperative period compared with melatonin or placebo. " 06/01/1999 - "Midazolam produced the highest scores for sedation at 30 and 60 min after administration and significant psychomotor impairment in the preoperative period compared with melatonin or placebo. "
3.	Polypharmacy 02/01/2013 - "Thus, in 2005, a National Institutes of Health expert consensus panel on chronic insomnia recommended dropping the term "secondary insomnia" in favor of the term "comorbid insomnia." Because CBTi does not carry the risks associated with some sleep medications (eg, dependency, polypharmacy, cognitive and psychomotor impairment), it is an attractive option for patients with other conditions. "
4.	Conscious Sedation 10/01/1996 - "These results demonstrate that flumazenil's effects on reversing psychomotor impairment are similar when midazolam or diazepam are used for conscious sedation. " 10/01/1996 - "Flumazenil reversal of psychomotor impairment due to midazolam or diazepam for conscious sedation for upper endoscopy."
5.	Premedication 06/01/2008 - "Many patients have preoperative anxiety; therefore, the development of a strong anxiolytic with minimal psychomotor impairment for premedication may be desirable. "