Psoralens

Linear furanocoumarins which are found in many PLANTS, especially UMBELLIFERAE and RUTACEAE, as well as PSORALEA from which they were originally discovered. They can intercalate DNA and, in an UV-initiated reaction of the furan portion, alkylate PYRIMIDINES, resulting in PHOTOSENSITIVITY DISORDERS.

Also Known As:

Networked: 295 relevant articles (11 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Borgatti, Monica: 4 articles (09/2010 - 09/2003)
2.	Bianchi, Nicoletta: 4 articles (09/2010 - 09/2003)
3.	Gambari, Roberto: 4 articles (09/2010 - 09/2003)
4.	Vedaldi, Daniela: 3 articles (09/2010 - 02/2008)
5.	Zuccato, Cristina: 3 articles (09/2010 - 02/2008)
6.	Dall'Acqua, Francesco: 3 articles (09/2010 - 02/2008)
7.	Lampronti, Ilaria: 3 articles (07/2008 - 09/2003)
8.	Young, Antony R: 3 articles (11/2006 - 06/2002)
9.	Dogra, Sunil: 2 articles (03/2015 - 01/2004)
10.	Sumiyoshi, Maho: 2 articles (01/2014 - 09/2013)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 11/01/2008 - "Narrowband UVB (NB-UVB), a relatively new light source that is not yet widely available, is effective for treating generalized psoriasis without the use of psoralens. " 03/01/1984 - "Forty-two adults with psoriasis vulgaris were treated total body thrice weekly with both ultraviolet B (UVB) and psoralens and ultraviolet A (PUVA) with the use of protocols shown to be effective with either treatment alone. " 03/01/1984 - "Combination of psoralens and ultraviolet A and ultraviolet B in the treatment of psoriasis vulgaris: a bilateral comparison study." 08/01/2002 - "A combination of psoralens and ultraviolet A radiation is widely used to treat psoriasis. " 10/01/1994 - "Treatment of psoriasis with psoralens and ultraviolet A. "
2.	Vitiligo 01/01/1998 - "A large variety of therapeutic agents are being tried for the treatment of vitiligo, but psoralens continue to be mainstay of treatment although they are not uniformly effective. " 03/01/2014 - "Three randomized, double-blind, placebo-controlled studies have demonstrated significant improvements in vitiligo when oral Polypodium leucotomos therapy was combined with psoralens plus ultraviolet A and narrowband ultraviolet B. " 05/01/1978 - "[Comparative analytical study of the effects of psoralens in vitiligo (findings in 70 patients) (author's transl)]." 05/20/1968 - "[Evaluation of the effectiveness of vitiligo treatment with psoralens; studies of the action mechanism]." 07/01/1965 - "[Studies on the mechanism of psoralens in the treatment of vitiligo]."
3.	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 05/01/2004 - "Extracorporeal photopheresis (ECP) is a form of photochemotherapy that involves exposure of white blood cells to UVA with psoralens and can be effective in Sézary syndrome and erythrodermic cutaneous T-cell lymphoma. " 11/01/2006 - "Although reminiscent of photochemotherapy using psoralens and UV(A) irradiation, an established treatment modality in dermatology particularly for the treatment of psoriasis and cutaneous T-cell lymphoma, a critical difference is the extreme photopotency of the iodinated bibenzimidazole, approximately 1,000-fold that of psoralens. " 01/01/1991 - "Production of hydrogen peroxide by cutaneous T-cell lymphoma following photopheresis with psoralens and ultraviolet light." 01/01/1999 - "Psoralenes (furocoumarins) in combination with ultraviolet (UV) A radiation (320-400 nm) are used in the treatment of vitiligo, psoriasis, cutaneous T-cell lymphoma and other skin and autoimmune diseases (PUFA therapy). " 03/15/1995 - "Psoralens are used clinically in the treatment of several skin diseases, including psoriasis, vitiligo, and cutaneous T cell lymphoma. "
4.	Eczema 05/01/1999 - "UVB and the combination of psoralens with UVA (PUVA) have become important therapeutic modalities, especially for psoriasis and eczema. " 05/01/1997 - "Topical PUVA-paint avoids some of the unwanted side effects of systemic psoralens and has been used successfully in the treatment of palmoplantar eczema and psoriasis. " 04/01/2005 - "Topical psoralen plus UVA (PUVA) is an effective treatment for localized forms of eczema, psoriasis, and palmoplantar pustulosis, which avoids some of the undesirable side-effects of systemic psoralens. "
5.	Erythema 08/01/2011 - "The latter is easier to deliver, with less resultant erythema than systemic psoralens and UVA which requires strict use of 24 hour protective eyewear. " 09/01/2005 - "Few side-effects of topical psoralens plus UVA (PUVA) treatment were noted, except a for few days of slight erythema caused by the high dose of UV." 01/01/1998 - "They photosensitize erythema, hyperpigmentation, and skin aging, affect immune system, etc. Molecular mechanisms of photochemical reactions of psoralens with substrates are also numerous. " 07/01/1983 - "Psoralens are photoactive chemicals which, when rubbed on the skin, react with sunlight to produce erythema, hyperpigmentation and blistering. " 01/01/1991 - "The possible formation of singlet oxygen via photoexcited psoralens has been associated with the occurrence of, amongst others, erythema. "

Related Drugs and Biologics

1.	Ficusin (Psoralen)
2.	Methoxsalen (Oxsoralen)
3.	Adrenal Cortex Hormones (Corticosteroids)
4.	Anthralin (Dithranol)
5.	Cyclosporine (Ciclosporin)
6.	Dosage Forms (Dosage Form)
7.	Psoralens
8.	5-methoxypsoralen (bergapten)
9.	DNA (Deoxyribonucleic Acid)
10.	angelicin

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Phototherapy (Light Therapy)
3.	PUVA Therapy
4.	Photopheresis
5.	Drug Therapy (Chemotherapy)