Pseudorabies

09/23/2022 - "Re-emerging pseudorabies (PR) caused by pseudorabies virus (PRV) variant has been prevailing among immunized herds in China since 2011, indicating that commercially available PR vaccine strains couldn't provide complete protection against novel, epidemic PRV variant. "
06/05/2014 - "The currently used Bartha-K61 strain is a very safe and effective vaccine against pseudorabies (PR) and has played a critical role in the control and eradication of PR worldwide. "
11/16/2020 - "The PRV-ΔgE/ΔgI/ΔTK-(CD2v) recombinant strain has strong immunogenicity, is safe and effective, and maybe a potential vaccine candidate for the prevention of ASF and Pseudorabies."
12/01/2017 - "Pseudorabies (PR) outbreaks have re-emerged in many pig farms with vaccination coverage in China, which suggests that current vaccine strains provide poor protection against novel, epidemic strains. "
11/28/2018 - "Recently, pseudorabies (PR) outbreaks have been reported in a large number of swine herds vaccinated with the Bartha-K61 vaccine in China, the current pseudorabies virus (PRV) belonging to Genotype II is differential genetically from Bartha-K61 vaccine belonging to Genotype I. Furthermore, it has been proved that the Bartha-K61 vaccine cannot provide sufficient protection against the current PRVs in China. "

01/01/2000 - "Whereas the relative contribution of several nonessential glycoproteins to neurovirulence and neurotropism of Pseudorabies virus (PrV), an alphaherpesvirus which causes Aujeszky's disease in pigs, has recently been uncovered in studies using viral deletion mutants, the importance of essential glycoproteins is more difficult to assess. "
07/01/2013 - "Expression and purification of Suid Herpesvirus-1 glycoprotein E in the baculovirus system and its use to diagnose Aujeszky's disease in infected pigs."
10/01/2008 - "DIVA diagnostic of Aujeszky's disease using an insect-derived virus glycoprotein E."
11/01/2001 - "In the alphaherpesvirus pseudorabies virus (PrV), the causative agent of Aujeszky's disease in pigs, the essential glycoprotein D (gD) mediates secondary attachment of virions to target cells by binding to newly identified cellular receptors (R. "
04/01/1997 - "Effect of maternally acquired Aujeszky's disease (pseudorabies) virus-specific antibody in pigs on establishment of latency and seroconversion to differential glycoproteins after low dose challenge."

08/01/1975 - "Electron microscopic studies of the DNA of defective and standard pseudorabies virions."
01/01/2023 - "Pseudorabies virus (PRV) is a double-stranded DNA virus that causes Aujeszky's disease and is responsible for economic loss worldwide. "
04/01/2021 - "Pseudorabies (Aujeszky's disease) virus DNA detection in swine nasal swab and oral fluid specimens using a gB-based real-time quantitative PCR."
01/01/2021 - "Pseudorabies virus (PRV) is an enveloped double-stranded DNA virus that is the etiological agent of Aujeszky's disease in pigs. "
05/11/2009 - "Protection in mice immunized with a heterologous prime-boost regime using DNA and recombinant pseudorabies expressing TgSAG1 against Toxoplasma gondii challenge."

04/01/1997 - "We compared the ability of an ELISA to detect antibodies to Aujeszky's disease (pseudorabies) virus gE in colostrum (test A) and in a single droplet of whole blood (test B) with the results obtained in serum (gold standard) in the target population by constructing and analyzing such curves. "
02/01/1995 - "[Vaccination trial against Aujeszky's disease: development of antibody titers in sow serum, colostrum and the serum of suckling piglets and the influence of maternal antibodies on the serologic vaccination reaction of weaned piglets]."
07/01/2020 - "The demonstrable presence of PRV antibodies in swine oral fluids suggests the possible use of oral fluids in pseudorabies surveillance."
11/01/2014 - "Antibodies to PRRSV and Aujeszky's disease, on the other hand, were not found at all. "
04/01/2010 - "The development of T-cell responses in pigs vaccinated against Aujeszky's disease in the presence of maternal-derived antibodies (MDA) was examined. "

07/01/1988 - "Two experimental porcine models of Aujeszky's disease (AD) were compared for assessing the efficacy of potential antiviral compounds. "
01/01/2020 - "This study aimed to reveal the antiviral ability of PBD-2 against pseudorabies virus (PRV), the causative pathogen of Aujeszky's disease, in PK-15 cells and in a PBD-2 expressing transgenic (TG) mouse model. "
05/01/2023 - "In addition to vaccination, the development of antiviral molecules is also a beneficial supplement to the control of Pseudorabies (PR). "
11/01/2022 - "In recent years, some drugs have been reported to treat PR; however, the variety of anti-pseudorabies drugs is limited, and the underlying mechanism of the antiviral effect of some drugs is unclear. "
02/01/2011 - "The immune response induced by intradermal vaccination using a needle-less device was evaluated in conventional pigs in comparison with the more conventional intramuscular vaccination; to this purpose, vaccination against Aujeszky's Disease (AD) was used as a model of antiviral immunity. "

01/30/1984 - "During a study designed to identify changes in the genomes that are observed in mutant populations of pseudorabies virions, a thymidine kinase-defective population of virions which contains genomes that possess inverted repeated sequences of unequal sizes has been identified. "
01/01/1994 - "Simultaneous inoculation of 50 doses of two modified live pseudorabies vaccines with either functional (strain Bartha) or inactivated (strain Begonia) thymidine kinase into piglets of 1 week of age did not induce any clinical signs of Aujeszky's disease. "
06/01/1992 - "Twenty four cloned isolates of Aujeszky's disease virus collected from outbreaks of Aujeszky's disease from 1981 through 1989 in Japan were characterized by their restriction endonuclease (RE) cleavage patterns, virulence for mice and thymidine kinase (TK) activity. "
08/01/1992 - "In order to compare the effect of the route of immunization on the efficacy of a modified live Aujeszky's disease (AD) vaccine, which had deletions in both thymidine kinase (TK-) and glycoprotein gIII genes (gpIII-), 20 six-week-old pigs were vaccinated by either the intramuscular (IM) (n = 10) or subcutaneous (SC) (n = 10) route. "
11/03/1990 - "Safety of an Aujeszky's disease vaccine based on deletion mutant strain 783 which does not express thymidine kinase and glycoprotein I."

12/06/2018 - "Dogs that are used for hunting feral swine are at high risk of exposure to pseudorabies because the disease is considered endemic in feral swine in the U.S."
12/06/2018 - "Pseudorabies detected in hunting dogs in Alabama and Arkansas after close contact with feral swine (Sus scrofa)."
01/01/2014 - "First reports of pseudorabies and winter ticks (Dermacentor albipictus) associated with an emerging feral swine (Sus scrofa) population in New Hampshire."
08/30/2013 - "Serological and molecular investigation of the prevalence of Aujeszky's disease in feral swine (Sus scrofa) in the subregions of the Pantanal wetland, Brazil."
07/01/2013 - "The US commercial swine industry obtained pseudorabies-free status in 2004, which was important because of the economic value of domestic swine production; however, feral swine remain competent hosts and represent a constant threat for reintroducing the virus into the commercial industry. "

01/15/2002 - "Our experiments in experimental animals and natural hosts suggested the efficiency and potential application of DNA vaccines for pseudorabies in pigs."
01/15/2002 - "Protection induced by intramuscular immunization with DNA vaccines of pseudorabies in mice, rabbits and piglets."
03/31/1999 - "Potency of an experimental DNA vaccine against Aujeszky's disease in pigs."
11/24/1998 - "Effect of vaccination route and composition of DNA vaccine on the induction of protective immunity against pseudorabies infection in pigs."
12/01/2005 - "Previously, we showed that murine prothymosin alpha (ProT) enhances the efficacy of a pseudorabies DNA vaccine delivered by bacterial vectors. "

08/01/1983 - "Relative activities of acyclovir and BW759 against Aujeszky's disease and equine rhinopneumonitis viruses."
08/01/1983 - "Compound BW759 (9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine) was shown to be about 230 times more active than acyclovir (9-[2-hydroxyethoxymethyl]guanine) (ACV) against Equid herpesvirus type 1 infection in Syrian hamsters and was more effective against Aujeszky's disease in mice. "
06/01/1985 - "Chemotherapy of Aujeszky's disease (pseudorabies) in the mouse by means of nucleoside analogues: bromovinyldeoxyuridine, acyclovir, and dihydroxypropoxymethylguanine."
01/01/1992 - "The combined antiviral effects of some flavonoid compounds and acycloguanosine (acyclovir, Zovirax) were studied on the multiplication of herpes simplex virus types 1 and 2 in HEp-2 cells and on pseudorabies (Aujeszky) virus in chick embryo fibroblast cells by the yield reduction method. "
01/01/1990 - "The antiviral effect of the combination acyclovir (ACV) and ribavirin (R) on herpes simplex virus type 1 (HSV-1) in diploid cell culture of human embryonal skin and muscle fibroblasts and the virus of pseudorabies in secondary culture of chicken embryonal fibroblasts is studied. "

01/01/1987 - "Comparative efficacy of three 2'-fluoropyrimidine nucleosides and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (BW B759U) against pseudorabies and equine rhinopneumonitis virus infection in vitro and in laboratory animals."
12/15/2021 - "Finally, VPD was shown to have an antiviral effect on the viral production of two strains of pseudorabies virus (wild type NIA-3 and recombinant PRV-XGF) at the concentrations ranging from 0.5 to 1.5 mM, suggesting that VPD could be a suitable alternative to nucleoside analogues as an antiherpetic drug against Aujeszky's disease."
06/01/1985 - "Chemotherapy of Aujeszky's disease (pseudorabies) in the mouse by means of nucleoside analogues: bromovinyldeoxyuridine, acyclovir, and dihydroxypropoxymethylguanine."
01/01/1987 - "The three 2'-fluoropyrimidine nucleosides 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC), 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil (FIAU), and 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-methyluracil (FMAU), showed high activity in RK13 monolayers against equine rhinopneumonitis virus, (EHV-1, IC50 range 0.02-0.18 microM), Aujeszky's disease virus (SHV-1, pseudorabies, IC50 range 0.25-7 microM) and infectious bovine rhinotracheitis virus (1BR, BHV-1, IC50 range 0.1-3 microM). "

09/01/1974 - "[Scientific foundation for the therapy of Aujeszky's disease]."
07/01/1988 - "Therapy of Aujeszky's disease (pseudorabies) in naturally infected and artificially inoculated piglets using BW B759U (9-[1,3-dihydroxy-2-propoxymethyl] guanine)."

06/07/2019 - "Intranasal administration with recombinant Bacillus subtilis induces strong mucosal immune responses against pseudorabies."
06/27/1987 - "Failure to induce Aujeszky's disease in cattle by intranasal administration of high doses of vaccine virus."

01/01/1995 - "To investigate the routes of neural spread of pseudorabies (Aujeszky's disease) virus (PRV), the effects of chemical sympathectomy by 6-hydroxydopamine (6-OHDA) on clinical signs and viral spread in mice inoculated intraocularly with PRV were examined. "

12/19/2018 - "The yeast@Au microspheres were successfully used in a flow cytometry immunoassay to detect Pseudorabies viral infection events. "

01/01/1994 - "Pigs were vaccinated by scarification or intramuscular injection with a swinepox virus-Aujeszky's disease (pseudorabies) recombinant (rSPV-AD) constructed by inserting the linked Aujeszky's disease virus genes coding for glycoproteins gp50 and gp63, attached to a vaccinia virus p7.5 promoter, into the thymidine kinase gene of swinepox virus. "