Pseudarthrosis (Pseudoarthrosis)

A pathologic entity characterized by deossification of a weight-bearing long bone, followed by bending and pathologic fracture, with inability to form normal BONY CALLUS leading to existence of the "false joint" that gives the condition its name. (Dorland, 27th ed)

Also Known As:

Networked: 1361 relevant articles (54 outcomes, 73 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Infection
3.	Congenital Abnormalities (Deformity)
4.	Scoliosis
5.	Low Back Pain (Lumbago)

Experts

1.	Lenke, Lawrence G: 12 articles (04/2015 - 01/2002)
2.	Bridwell, Keith H: 11 articles (07/2014 - 01/2002)
3.	Adogwa, Owoicho: 7 articles (04/2015 - 10/2011)
4.	Epstein, Nancy E: 7 articles (01/2015 - 09/2003)
5.	Riew, K Daniel: 6 articles (10/2015 - 05/2008)
6.	Mummaneni, Praveen V: 6 articles (09/2015 - 08/2009)
7.	Deviren, Vedat: 6 articles (05/2015 - 03/2002)
8.	Tsirikos, Athanasios I: 6 articles (01/2015 - 06/2003)
9.	Qiu, Yong: 6 articles (12/2014 - 08/2005)
10.	Cho, Tae-Joon: 6 articles (12/2014 - 05/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pseudarthrosis:

1.	TitaniumIBA 07/15/2006 - "To evaluate the safety and efficacy of using an integrated titanium mesh cage and pedicled rib flap for thoracic spine reconstruction in patients at high risk of pseudarthrosis. " 01/01/2008 - "We did not confront any loss of correction, pseudoarthrosis, and titanium mesh cage collapse or implant failure. " 11/01/2007 - "Second, we compare x-ray outcomes, including pseudarthrosis rates and angulation of healing, between patients receiving resorbable plates and a control group of patients receiving titanium plates. " 01/01/2002 - "The authors think that the use of titanium mesh cages anteriorly with single or dual rod anterior instrumentation systems provide for adequate lordotic sagittal alignment and an acceptable pseudarthrosis rate." 05/01/1999 - "Wear debris is generated by the use of titanium spinal instrumentation in patients with a pseudarthrosis. "
2.	recombinant human bone morphogenetic protein-2IBA 05/01/2011 - "The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for the treatment of congenital pseudarthrosis of the tibia has been investigated in only one previous study, with promising results. " 04/01/2010 - "The purpose of this study was to analyze the pseudarthrosis rate in a large series of recombinant human bone morphogenetic protein-2 (rhBMP-2) augmented multilevel (> or =3 levels) anterior cervical fusions. " 02/01/2011 - "Analysis of prevertebral soft-tissue swelling and dysphagia in multilevel anterior cervical discectomy and fusion with recombinant human bone morphogenetic protein-2 in patients at risk for pseudarthrosis."
3.	Polymethyl Methacrylate (Sol)IBA 04/01/2012 - "To investigate the clinical efficacy of polymethylmethacrylate (PMMA) augmentation in vertebral pseudarthrosis after osteoporotic vertebral fractures. " 12/01/2013 - "In most cases, an intravertebral cleft was present, and we filled it with polymethylmethacrylate, which healed the pseudarthrosis. " 01/01/2011 - "PMMA assisted discectomy shows a high rate of pseudarthrosis. " 01/01/2011 - "Polymethylmethacrylate-assisted ventral discectomy: rate of pseudarthrosis and clinical outcome with a minimum follow-up of 5 years." 01/01/2011 - "This study presents a long term comparison of clinical and radiological data from patients with pseudarthrosis and solid arthrodesis after PMMA assisted ventral discectomy was performed. "
4.	Teriparatide (Parathar)FDA Link 09/01/2015 - "Because of the numerous positive results, from the point of view of teriparatide treatment, a multicentric, prospective randomized study on the treatment of aseptic pseudarthrosis should be initiated."
5.	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 04/01/2014 - "In the therapy for pseudarthroses of the proximal tibia, the human recombinant bone morphogenetic proteins (BMP-2 and BMP-7) have been used for several years. " 04/01/2014 - "[Use of Bone Morphogenetic Proteins (BMPs) for the Treatment of Pseudarthroses - Efficiency and Therapy Failure]." 08/01/2012 - "A type 2 recombinant human bone morphogenetic protein (rhBMP2) and Masquelet's procedure were used in three children presenting with congenital pseudarthrosis of the tibia (CPT). " 08/01/2012 - "Masquelet's procedure and bone morphogenetic protein in congenital pseudarthrosis of the tibia in children: a case series and meta-analysis." 04/01/1996 - "Partially purified canine bone morphogenetic protein (cBMP) was used in the repair of a delayed union fracture and a pseudoarthrosis. "
6.	polyetheretherketoneIBA 12/01/2009 - "Given our experience, we currently reserve the use of PEEK and rhBMP-2 for use in those patients who are at greatest risk of pseudoarthrosis." 12/01/2009 - "Pseudoarthrosis, shown as a horizontal radiolucent fissure through the midportion of the PEEK cage on CT, occurred in four patients. " 03/01/2011 - "For aged and osteoporotic patients with degenerative cervical spinal disorders, three-level anterior cervical arthrodesis with PEEK cages and plate fixation reduced the pseudarthrosis and adjacent segment degeneration and improved the clinical outcomes. " 02/01/2011 - "Multilevel ACDF procedures using PEEK grafts and rhBMP-2 can be performed safely in patients with multiple risk factors for pseudarthrosis with excellent fusion outcomes."
7.	Stainless Steel (Steel, Stainless)IBA 09/15/2008 - "Although the average follow-up in the Ti group was significantly shorter than in the SS group, the 4.75-mm titanium alloy construct resulted in improved maintenance of deformity correction at 2-years postop and a lower incidence of instrumentation-related complications (pseudarthrosis, rod breakage, and surgical revisions) compared to the 4.0-mm stainless steel construct. "
8.	AlloysIBA 09/15/2008 - "Although the average follow-up in the Ti group was significantly shorter than in the SS group, the 4.75-mm titanium alloy construct resulted in improved maintenance of deformity correction at 2-years postop and a lower incidence of instrumentation-related complications (pseudarthrosis, rod breakage, and surgical revisions) compared to the 4.0-mm stainless steel construct. "
9.	infliximab (Remicade)FDA Link 05/01/2006 - "Radiographs showed rapid exacerbation of preexisting spinal pseudoarthrosis at the T11-T12 level after infliximab therapy. " 05/01/2006 - "To describe a case with paraparesis caused by rapid exacerbation of preexisting spinal pseudoarthrosis after infliximab therapy for advanced AS. " 05/01/2006 - "Paraparesis due to exacerbation of preexisting spinal pseudoarthrosis following infliximab therapy for advanced ankylosing spondylitis." 05/01/2006 - "Although this patient could have certainly become myelopathic over time without undergoing infliximab therapy, the patient's history and radiographic course suggest that suppression of inflammation by infliximab improved his activities of daily living, which paradoxically exacerbated preexisting spinal pseudoarthrosis and quickened the onset of subsequent myelopathy."
10.	Polyurethanes (Polyurethane)IBA 09/01/1961 - "(Histomorphological study of a pseudoarthrosis treated with "ostamer")]." 02/17/1961 - "[Microscopic studies on a pseudarthrosis treated with a "bone glue" (Ostamer)]."

Therapies and Procedures

1.	Arthrodesis 07/01/2011 - "In this study, using the best widely available CT technologies and the ideal gold standard, thin-cut CT remained less than ideal for the assessment of lumbar arthrodesis/pseudarthrosis. " 09/01/1993 - "The risk of pseudarthrosis was significantly greater after a multiple-level arthrodesis than after a single-level arthrodesis (p < 0.01). " 08/01/1992 - "For distal radio-ulnar joint disorders, the Sauvé-Kapandji procedure, previously attributed to Lauenstein, of arthrodesis of the joint and distal ulnar pseudarthrosis is a very useful procedure, yet is not often practised. " 02/01/2013 - "The distal radioulnar joint can be arthrodesed, while forearm pronation and supination are maintained or even improved by creating a pseudoarthrosis of the ulna just proximal to the arthrodesis. " 11/01/2010 - "The distal radioulnar joint can be arthrodesed, while forearm pronation and supination are maintained or even improved by creating a pseudoarthrosis of the ulna just proximal to the arthrodesis. "
2.	Transplants (Transplant) 06/01/1999 - "The best treatment, especially in unfavorable types, seems to be a radical resection of the pseudarthrosis and reconstruction with a free vascularized fibular graft." 02/10/1978 - "The method described by Matti-Russe using an iliac graft has given good results in old fractures and pseudarthroses, causing 95% fracture healing in old fractures and 76% in pseudarthroses." 01/01/1979 - "[A new treatment for congenital tibial pseudoarthrosis---free fibula graft with microvascular anastomosis: a preliminary report of 12 cases (author's transl)]." 07/01/2007 - "Three patients undergoing surgery in the first year of the study exhibited plate/graft extrusion (1 to 3 wk) or pseudarthroses (2 to 6 mo); subsequent improvements in surgical technique eliminated these complications in the last 5 years of the study. " 04/30/1960 - "[A contribution to the efficacy of Phemister's bone graft in the treatment of pseudarthrosis]."
3.	Osteotomy 06/01/1993 - "This patient was treated successfully with excision of the pseudoarthrosis, shortening osteotomy of the ulna, grafting, and intramedullary fixation of both the radius and the ulna. " 04/01/2015 - "A central hook-rod construct is safe, controlled, and effective for applying compressive forces to close various spinal osteotomies without fixation failure or pseudarthrosis at the osteotomy site noted at a follow-up of 5 or more years. " 04/01/2012 - "The purpose of this study is to explore the outcomes of pedicle subtraction osteotomy (PSO) at the level of pseudarthrotic lesion combined with supplemental anterior fusion for patients suffering from kyphotic pseudarthrosis in AS. " 02/01/2008 - "The goals of this study were to develop a new intramedullary, rotation-stable locking device and evaluate it biomechanically and in vivo for maintenance of a critical size osteotomy gap in a model of conscious pseudarthrosis. " 05/01/1999 - "From this study it can be concluded that the dove-tail osteotomy of the mandible is the best possible design of temporary anterior mandibular osteotomy in preventing pseudoarthrosis due to the mainly primary bone contact and gap healing process."
4.	Bone Transplantation (Bone Grafting) 04/01/1982 - "The stable plate-osteosynthesis is regarded as the best treatment in combination with an autologous bone grafting in cases of atrophic or defect-pseudarthrosis. " 01/01/2011 - "Excision of pseudarthrosis, intramedullary rodding, and cortical bone grafting is very effective in achieving union of congenital pseudarthrosis of the tibia but a proportion of children will require additional operations to deal with refractures and other complications. " 12/01/2014 - "The pseudarthrosis revision surgery with humeral head preserving re-osteosynthesis with bone transplantation is an effective treatment for non-unions of the proximal humerus and the proximal humeral shaft and the current results showed high bone consolidation rates. " 01/01/2011 - "This study evaluates the results of the treatment of congenital pseudarthrosis of the tibia by excision of the pseudarthrosis, transarticular intramedullary rodding, and onlay autogenous cortical bone grafting in a cohort of children followed till skeletal maturity. " 03/01/2009 - "The purpose of this study was to evaluate the long-term results of a technique consisting of excision of the pseudarthrosis, autologous bone grafting, and insertion of an intramedullary Kirschner wire into the tibia. "
5.	Decompression 12/01/2007 - "There were four complications associated with the index procedure, all early in the series, including three cases of pseudarthrosis and one patient that had an insufficient decompression of basilar invagination. " 11/01/2005 - "Use standardized outcome measures to evaluate the results of posterior fusion with selective nerve root decompression as a treatment option for symptomatic pseudarthrosis of the cervical spine. " 09/15/2003 - "In anterior cervical decompression and fusion (ACDF), because the risks and likelihood of pseudarthrosis increase with the number of treated segments, attempts are typically made to limit the number of treated levels. " 01/15/2002 - "Because pseudarthrosis resulted in poorer clinical outcomes, strut grafting should be considered after multilevel anterior cervical decompression to increase the likelihood of successful fusion." 08/01/1997 - "In the group of twenty-two patients (non-smokers) who had been managed without instrumentation, none of the twelve managed without decompression had a pseudarthrosis compared with three of the ten managed with decompression (p = 0.04). "