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Prothrombin (Factor II)

A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
Also Known As:
Factor II; Blood Coagulation Factor II; Differentiation Reversal Factor; Factor II, Coagulation; Factor, Differentiation Reversal; II, Coagulation Factor; Coagulation Factor II; Blood-coagulation factor II
Networked: 5251 relevant articles (120 outcomes, 483 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Akar, Nejat: 20 articles (08/2013 - 03/2003)
2. Middeldorp, Saskia: 15 articles (03/2021 - 07/2003)
3. De Stefano, V: 15 articles (12/2016 - 01/2000)
4. De Stefano, Valerio: 15 articles (11/2014 - 05/2002)
5. Rosendaal, F R: 15 articles (10/2010 - 01/2000)
6. Grottke, Oliver: 14 articles (10/2021 - 12/2010)
7. Schöchl, Herbert: 14 articles (10/2021 - 01/2010)
8. Glueck, Charles J: 14 articles (07/2020 - 06/2002)
9. Martinelli, Ida: 14 articles (10/2017 - 05/2002)
10. Kawakami, Tamihiro: 13 articles (09/2021 - 12/2007)

Related Diseases

1. Hemorrhage
2. Thrombosis (Thrombus)
3. Hemophilia A (Haemophilia)
4. Wounds and Injuries (Trauma)
5. Hypoprothrombinemias (Prothrombin Deficiency)

Related Drugs and Biologics

1. factor V Leiden
2. Bilirubin
3. Warfarin (Coumadin)
4. Fibrinogen (Factor I)
5. Vitamin K
6. recombinant FVIIa (rFVIIa)
7. Antibodies
8. Thrombin
9. Factor V (Coagulation Factor V)
10. Factor VIII (Coagulation Factor VIII)

Related Therapies and Procedures

1. Therapeutics
2. Liver Transplantation
3. Catheters
4. Length of Stay
5. Aftercare (After-Treatment)