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Chondroitin Sulfate Proteoglycans

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Proteoglycans consisting of proteins linked to one or more CHONDROITIN SULFATE-containing oligosaccharide chains.

Also Known As:

Chondroitin Sulfate Proteoglycan; Proteochondroitin Sulfate; Proteoglycan, Chondroitin Sulfate; Proteoglycans, Chondroitin Sulfate; Sulfate Proteoglycan, Chondroitin; Sulfate Proteoglycans, Chondroitin; Proteochondroitin Sulfates

Networked: 367 relevant articles (4 outcomes, 34 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Silver, Jerry: 8 articles (04/2015 - 04/2006)
2.	Ferrone, Soldano: 8 articles (11/2011 - 01/2004)
3.	Bassols, Anna: 7 articles (02/2011 - 02/2002)
4.	Tom, Veronica J: 6 articles (08/2015 - 05/2008)
5.	Levine, Joel M: 6 articles (12/2014 - 05/2002)
6.	Stallcup, William B: 5 articles (12/2014 - 04/2002)
7.	Snow, Diane M: 5 articles (02/2014 - 06/2002)
8.	Li, Shuxin: 4 articles (09/2015 - 02/2007)
9.	Wight, Thomas N: 4 articles (04/2014 - 05/2005)
10.	Houlé, John D: 4 articles (01/2013 - 05/2008)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 05/15/1995 - "In this study, we evaluated the potential role for a specific melanoma-associated chondroitin sulfate proteoglycan core protein, termed NG2, to collaborate with alpha 4 beta 1 integrin in focal contact formation in human melanoma cells. " 11/01/1986 - "Immunolocalization studies using whole-mount electron microscopy revealed that the chondroitin sulfate proteoglycan was present almost exclusively on microspikes, a microdomain of the melanoma cell surface. " 10/25/1984 - "Monoclonal antibody (Mab) 9.2.27 was utilized in a combination of biosynthetic and biochemical investigations as an immunological probe for the study of chondroitin sulfate proteoglycans (CSP) in human melanoma cells. " 03/01/2015 - "CSPG4-negative melanoma cell line WM1552C was transfected with CSPG4 and CSPG4 lacking cytoplasmic domain (melanoma-associated chondroitin sulfate proteoglycan (MCSP)ΔCD). " 12/01/2011 - "These cells located in the basal layer were negative for connexin-43 and positive for melanoma-associated chondroitin sulfate proteoglycan, containing holoclones with 0.2% CFE, thus representing the SC population. "
2.	Neoplasms (Cancer) 11/01/2012 - "The aim of this study was to analyze the potential role of NG2 chondroitin sulfate proteoglycan in amoeboid morphology and invasiveness of cancer cells. " 08/01/2014 - "Contributions of chondroitin sulfate proteoglycans to neurodevelopment, injury, and cancer." 09/25/2013 - "Specifically, noninvasive lesions are associated with a rich matrix containing substantial amounts of glycosylated chondroitin sulfate proteoglycans (CSPGs), whereas glycosylated CSPGs are essentially absent from diffusely infiltrating tumors. " 10/01/2012 - "We provide evidence that one third of BM-derived GFP(+) cells infiltrating the tumor expressed the chondroitin sulfate proteoglycan NG2 (pericytic marker) or α-smooth muscle actin (α-SMA, myofibroblast marker), whereas almost 90% of Thy1(+) fibroblasts were originating from resident GFP-negative cells. " 08/01/2007 - "The system developed was tested by assaying for chondroitin sulfate proteoglycans in sera from patients with various cancers and comparing the results to those obtained for sera from healthy people. "
3.	Glioma (Gliomas) 09/24/1993 - "Recent studies have shown that in glioma cells, most of the soluble secreted APP occurs as a chondroitin sulfate proteoglycan (CSPG). " 09/25/2009 - "Chondroitin sulfate proteoglycans (CSPGs) are among the major inhibitory components in the neural matrix, but surprisingly, some are up-regulated in gliomas and act as pro-invasive signals. " 08/01/1999 - "The expression and function of NG2, a transmembrane chondroitin sulfate proteoglycan was studied in human gliomas of various histological types in culture using immunocytochemistry and flow cytometry. " 08/01/1995 - "Previously, we showed that in C6 glioma cell cultures, secreted APP nexin II occurs as the core protein of a chondroitin sulfate proteoglycan (CSPG). " 05/14/1993 - "Here we present evidence that full length APP-chondroitin sulfate proteoglycan is present on the cell surface of C6 glioma cells. "
4.	Cicatrix (Scar) 09/04/2015 - "Chondroitin sulfate proteoglycans (CSPGs) are highly expressed by reactive scars and are potent contributors to the non-permissive environment in mature CNS. " 08/05/2015 - "This is due to: (1) the presence of inhibitory molecules, e.g., chondroitin sulfate proteoglycans (CSPG), in the glial scar at the lesion; and (2) the diminished growth capacity of adult neurons. " 08/01/2015 - "We previously demonstrated that injury-induced upregulation of matrix chondroitin sulfate proteoglycans (CSPGs) restricts the survival, migration, integration, and differentiation of NPCs following SCI. CSPGs are long-lasting components of the astroglial scar that are formed around the lesion. " 01/01/2015 - "Extracellular matrix molecule chondroitin sulfate proteoglycans (CSPGs) are highly upregulated in scar tissues and form a potent chemical barrier for CNS axon regeneration. " 10/01/2014 - "Astrogliosis and glial scar deposition, measured by GFAP-positive and chondroitin sulfate proteoglycan-positive volume, was significantly reduced. "
5.	Spinal Cord Injuries (Spinal Cord Injury) 12/03/2014 - "NG2 is purportedly one of the most growth-inhibitory chondroitin sulfate proteoglycans (CSPGs) produced after spinal cord injury. " 04/02/2014 - "Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. " 04/02/2014 - "Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury." 02/01/2013 - "Conditional Sox9 ablation reduces chondroitin sulfate proteoglycan levels and improves motor function following spinal cord injury." 06/01/2011 - "As a physical barrier to regenerating axons, reactive astrogliosis is also a biochemical barrier which can secrete inhibitory molecules, including chondroitin sulfate proteoglycans (CSPGs) in the pathological mechanism of spinal cord injury (SCI). "

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4.	Exotoxins
5.	Immunotoxins (Immunotoxin)
6.	Hyaluronic Acid (Hyaluronan)
7.	Proteoglycans (Proteoglycan)
8.	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)
9.	Amyloid (Amyloid Fibrils)
10.	Versicans (Versican)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Transplants (Transplant)
3.	Homologous Transplantation (Allograft)
4.	Immunotherapy
5.	Transplantation (Transplant Recipients)