Protein Synthesis Inhibitors

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.

Also Known As:

Networked: 139 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gold, Paul E: 3 articles (05/2009 - 07/2007)
2.	Anokhin, K V: 2 articles (03/2013 - 11/2000)
3.	Solntseva, S V: 2 articles (09/2012 - 11/2007)
4.	Nikitin, V P: 2 articles (09/2012 - 11/2007)
5.	Canal, Clinton E: 2 articles (08/2007 - 07/2007)
6.	Bishopric, Nanette H: 2 articles (04/2007 - 07/2004)
7.	Webster, Keith A: 2 articles (04/2007 - 07/2004)
8.	Li, Huifang: 2 articles (04/2007 - 07/2004)
9.	Dougherty, Christopher J: 2 articles (04/2007 - 07/2004)
10.	Frazier, Donna P: 2 articles (04/2007 - 07/2004)

Related Diseases

1.	Shock 06/03/1996 - "Modification of the alternative splicing process of testosterone-repressed prostate message-2 (TRPM-2) gene by protein synthesis inhibitors and heat shock treatment." 12/01/1987 - "Moreover, HSP70 mRNA is more stable in cells treated with protein synthesis inhibitors, suggesting that a heat shock-sensitive labile protein regulates its turnover. " 11/01/1987 - "Transcriptional activation of the major immediate early transcription unit of human cytomegalovirus by heat-shock, arsenite and protein synthesis inhibitors." 05/20/1994 - "Analysis of the effects of protein synthesis inhibitors demonstrated that neither cycloheximide nor puromycin was effective in blocking the induction of HSE-binding activity in cells recovering from a transient cold shock. " 11/29/1996 - "c-Jun NH2-terminal protein kinase (JNK), a member of the mitogen-activated protein kinase family, is activated in response to many stressful stimuli including heat shock, UV irradiation, protein synthesis inhibitors, and inflammatory cytokines. "
2.	Mycoplasma Pneumonia 03/01/1995 - "Macrolide and tetracycline antibiotics, which are protein synthesis inhibitors, are effective in the treatment of mycoplasma pneumonia. "
3.	Amnesia (Dissociative Amnesia) 09/01/1992 - "In the present study, the effect of subcutaneously administered CER on amnesia induced by protein synthesis inhibitors was examined in passive and active avoidance responses and in the Morris water maze test. " 08/01/1982 - "These studies further document the effects of protein synthesis inhibitors on CA mechanisms and suggest that disruption of CA biochemistry may play a role in the amnesia observed after administration of protein synthesis inhibitors." 03/01/2013 - "Protein synthesis inhibitors injected before or immediately after learning episode, produce significant amnesia. " 11/01/2007 - "Thus, we have provided the first demonstration that recovery of a long-term memory "trace" on exposure to relatively low doses of protein synthesis inhibitors produces transient and short-lived amnesia, lasting 2-3 h, while long-term, irreversible amnesia occurs after longer-lasting or more profound suppression of protein synthesis. " 11/01/2007 - "Effects of protein synthesis inhibitors during reactivation of associative memory in the common snail induces reversible and irreversible amnesia."
4.	Infection 09/01/2008 - "Clinical studies exploring protein synthesis inhibitors as future candidates for treatment of intestinal infections caused by Stx2-producing STEC should therefore include knowledge of the toxin variant in addition to the subtype." 05/01/2003 - "Targeting bacterial virulence: the role of protein synthesis inhibitors in severe infections. " 09/01/2015 - "aureus (MRSA) is reportedly enhanced by β-lactams, but inhibited by protein-synthesis inhibitors, a fact that has influenced management of infections associated with PVL. " 11/01/2010 - "Our results suggest that such protein synthesis inhibitors may exacerbate the progression of CA-MRSA disease when applied at concentrations that are too low or when treating infections caused by strains resistant to those antibiotics." 07/15/1988 - "The activation of macrophage resistance to infection by LK was 1) not signal sequence dependent, 2) absent in cells treated with the second signal at lower (4 degrees C) temperatures and in the presence of protein synthesis inhibitors, and 3) induced by the cooperation of IFN-gamma and LK of m.w. "
5.	Seizures (Seizure) 07/01/1984 - "This study examined the effects of protein synthesis inhibitors on sleep and seizure susceptibility in amygdala-kindled cats. " 07/01/2010 - "The present findings suggest that the mechanisms underlying kindling are resistant to modification, even under the influence of protein synthesis inhibitors, and that there are important differences between the processes of learning and kindling seizures." 05/01/2004 - "These data parallel our previous data revealing that protein synthesis inhibitors prevent induction but not expression of group I mGluR-mediated persistent seizure-length discharges. " 07/01/1984 - "The results extend previous work showing that protein synthesis inhibitors which suppress REM sleep increase seizure susceptibility only in animals that are either highly predisposed to seizures or that display REM sleep disruption as the sole sleep deficit associated with their seizure condition." 07/01/1984 - "Effects of protein synthesis inhibitors on sleep and amygdala-kindled seizure thresholds in cats."

Related Drugs and Biologics

1.	Cycloheximide (Cicloheximide)
2.	Puromycin
3.	Anti-Bacterial Agents (Antibiotics)
4.	Tetracycline (Achromycin)
5.	Anisomycin
6.	Complementary RNA (cRNA)
7.	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
8.	Methicillin (Metin)
9.	Panton-Valentine leukocidin
10.	RNA (Ribonucleic Acid)

Related Therapies and Procedures

1.	Ligation
2.	Injections
3.	Aftercare (After-Treatment)