Histone-Lysine N-Methyltransferase

An enzyme that catalyzes the methylation of the epsilon-amino group of lysine residues in proteins to yield epsilon mono-, di-, and trimethyllysine.

Also Known As:

Histone-Lysine Methyltransferase; Histone Lysine Methyltransferase; Histone Lysine N Methyltransferase; Methyltransferase, Histone-Lysine; Methyltransferase, Protein Lysine; N-Methyltransferase, Histone-Lysine; Protein Lysine Methyltransferase; Protein Methylase III; Protein Methyltransferase III; S-Adenosyl-L-methionine:histone-L-lysine N(6)-methyltransferase

Networked: 196 relevant articles (1 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - One-Carbon Group Transferases
      - Methyltransferases: 5778
        Protein Methyltransferases: 69
        Histone Methyltransferases: 1204
        Histone-Lysine N-Methyltransferase: 196
        Polycomb Repressive Complex 2: 337
        human NSD3 protein: 1
        human SMYD2 protein: 1
        Arabidopsis At2g31650 protein
        Arabidopsis AT4G15180 protein
        Arabidopsis ATX3 protein
        Arabidopsis ATX4 protein
        Arabidopsis ATX5 protein
        Arabidopsis LAZ2 protein
        Arabidopsis SDG26 protein
        Arabidopsis SUVH1 protein
        Arabidopsis SUVH2 protein
        Arabidopsis SUVH3 protein
        Arabidopsis SUVH4 protein
        Arabidopsis SUVH6 protein
        Arabidopsis SUVR4 protein
        Arabidopsis SUVR5 protein
        C elegans ASH-2 protein
        C elegans DOT-1.1 protein
        C elegans Met-1 protein
        C elegans Met-2 protein
        C elegans Set-1 protein
        C elegans SET-25 protein
        C elegans SET-4 protein
        C elegans SET-6 protein
        cytochrome C methyltransferase
        Drosophila egg protein
        Drosophila Hmt4-20 protein
        Drosophila NSD protein
        Drosophila PR-Set7 protein
        Drosophila PRC2 protein
        Drosophila Set1 protein
        Drosophila Set2 protein
        Drosophila SETD3 protein
        Drosophila TRR protein
        human ASH1L protein
        human ATPSCKMT protein
        human DOT1L protein
        human EHMT1 protein
        human EHMT2 protein
        human KMT2A protein
        human KMT2B protein
        human KMT5A protein
        human KMT5C protein
        human MLL4 protein
        human NSD1 protein
        human NSD2 protein
        human PRDM13 protein
        human PRDM2 protein
        human PRDM7 protein
        human PRDM9 protein
        human Setd1A protein
        human SETD1B protein
        human SETD2 protein
        human SETD7 protein
        human SETDB1 protein
        human SETDB2 protein
        human SETMAR protein
        human SMYD3 protein
        human SUV39H2 protein
        mouse Ash1l protein
        mouse Atpsckmt protein
        mouse Dot1l protein
        mouse G9a protein
        mouse GLP protein
        mouse Kmt2a protein
        mouse Kmt2b protein
        mouse MLL3 protein
        mouse MLL4 protein
        mouse MLL5 protein
        mouse Nsccn1 protein
        mouse Nsd1 protein
        mouse Prdm13 protein
        mouse Prdm2 protein
        mouse prdm9 protein
        mouse SET8 protein
        mouse Setd1b protein
        mouse SETD2 protein
        mouse Setd7 protein
        mouse Setd8 protein
        mouse SETDB1 protein
        mouse Setdb2 protein
        mouse Smyd2 protein
        mouse Smyd3 protein
        mouse Suv39h2 protein
        mouse Suv4-20h protein
        mouse WHSC1 protein
        mouse WHSC1L1 protein
        rat Ash1l protein
        rat DOT1L protein
        rat Ehmt2 protein
        rat Kmt5c protein
        rat Nsd2 protein
        rat Prdm2 protein
        rat Setd2 protein
        rat Setd7 protein
        rat SMYD2 protein
        ribulose-1,5-bisphosphate carboxylase-oxygenase large subunit epsilonN-methyltransferase
        S cerevisiae BRE2 protein
        S cerevisiae Dot1 protein

Experts

1.	Hamamoto, Ryuji: 6 articles (11/2021 - 10/2011)
2.	Arrowsmith, Cheryl H: 5 articles (01/2019 - 08/2010)
3.	Nakamura, Yusuke: 5 articles (07/2017 - 10/2011)
4.	Jeltsch, Albert: 4 articles (01/2020 - 11/2012)
5.	Kudithipudi, Srikanth: 4 articles (01/2020 - 11/2012)
6.	Brown, Peter J: 4 articles (01/2019 - 08/2010)
7.	Vedadi, Masoud: 4 articles (01/2019 - 08/2010)
8.	Cho, Hyun-Soo: 3 articles (11/2021 - 10/2011)
9.	Allali-Hassani, Abdellah: 3 articles (01/2019 - 08/2010)
10.	Dong, Aiping: 3 articles (01/2019 - 08/2010)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2014 - "New protein lysine methyltransferase (PKMT) assays are needed to facilitate screening for improved PKMT inhibitors, because PKMTs are mutated or overexpressed in several cancers. " 01/01/2022 - "Frequent truncation mutations of the histone lysine N-methyltransferase KMT2C have been detected by whole exome sequencing studies in various cancers, including malignancies of the prostate. " 01/01/2022 - "Exome sequencing studies have shown that the histone-lysine N-methyltransferase 2 (KMT2) gene is one of the most commonly mutated genes in a range of human malignancies and is linked to some of the most common and deadly solid tumors. " 12/01/2021 - "Numerous studies have shown that SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) is involved in the initiation and progression of many cancers. " 01/01/2015 - "Previous studies have suggested that the histone lysine methyltransferase G9a (EHMT2) is required to perpetuate malignant phenotypes through multiple mechanisms in a variety of cancer types. "
2.	Carcinogenesis 06/01/2018 - "The present study aimed to explore the possible oncogenic role of euchromatic histone lysine methyltransferase 1 (EHMT1) in gastric carcinogenesis. " 12/08/2020 - "Aberrant Activity of Histone-Lysine N-Methyltransferase 2 (KMT2) Complexes in Oncogenesis." 07/01/2017 - "Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization." 01/01/2016 - "We analyzed underlying molecular mechanisms of one of the identified genes, the Histone-lysine N-methyltransferase KMT2D, and showed that it promotes tumorigenesis by dysregulating a subset of transcriptional enhancers and target genes involved in cell migration. " 01/01/2023 - "Histone lysine methyltransferase SMYD3 promotes oral squamous cell carcinoma tumorigenesis via H3K4me3-mediated HMGA2 transcription."
3.	Multiple Myeloma 10/15/2013 - "Histone lysine methyltransferase NSD2 (WHSC1/MMSET) is overexpressed frequently in multiple myeloma due to the t(4;14) translocation associated with 15% to 20% of cases of this disease. " 06/15/2011 - "MMSET (WHSC1/NSD2) is a SET domain-containing histone lysine methyltransferase the expression of which is deregulated in a subgroup of multiple myelomas with the t(4;14)(p16;q32) translocation associated with poor prognosis. " 05/01/2011 - "Multiple myeloma SET (Suppressor of variegation, Enhancer of zeste, and Trithorax) domain (MMSET) is a histone lysine methyltransferase deregulated in a subgroup of multiple myelomas with the t(4;14)(p16;q32) translocation and poor prognosis. " 04/01/2013 - "The multiple myeloma SET domain (MMSET) involved in the t(4;14)(p16;q32) chromosomal translocation encodes a histone lysine methyltransferase. " 11/18/2011 - "The histone lysine methyltransferase NSD2 (MMSET/WHSC1) is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. "
4.	Stomach Neoplasms (Stomach Cancer) 08/01/2020 - "The present study aimed to evaluate whether the H3K9me2 methylation level is associated with the expression level of euchromatic histone lysine methyltransferase 2 (EHMT2) in the prognosis of gastric cancer (GC). " 01/01/2023 - "To investigate the expression of histone lysine N-methyltransferase 2D (KMT2D) in gastric cancer patients and its relationship with the prognosis. " 01/01/2021 - "Frequent mutations of genes in the histone-lysine N-methyltransferase 2 (KMT2) family members were identified in gastric cancers (GCs). " 06/01/2018 - "Euchromatic histone lysine methyltransferase 1 regulates cancer development in human gastric cancer by regulating E-cadherin." 01/01/2018 - "Histone lysine methyltransferase 2D (KMT2D/MLL2) is a known cancer-related protein; however, its function in gastric cancer (GC) remains uncharacterized. "
5.	Breast Neoplasms (Breast Cancer) 08/01/2019 - "Association between histone lysine methyltransferase KMT2C mutation and clinicopathological factors in breast cancer." 12/06/2016 - "We performed a FOXA1 rapid immunoprecipitation mass spectrometry of endogenous proteins (RIME) screen in ERα-positive MCF-7 breast cancer cells and found histone-lysine N-methyltransferase (MLL3) as the top FOXA1-interacting protein. " 08/09/2019 - "Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. " 07/01/2016 - "SET7/9 is a protein lysine methyltransferase that had been initially identified as a histone lysine methyltransferase which generates monomethylation at histone 3 lysine 4. Different functions were attributed to the protein methylation mediated by SET7/9. In this study, we found that the expression of SET7/9 declined in a majority of the human breast cancer tissues examined compared with normal tissues. " 11/01/2018 - "Inhibition of euchromatin histone-lysine N-methyltransferase 2 sensitizes breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through reactive oxygen species-mediated activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway activation."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Histones (Histone)
3.	Lysine (L-Lysine)
4.	Histone-Lysine N-Methyltransferase
5.	Methyltransferases
6.	Phosphotransferases (Kinase)
7.	Histone Methyltransferases
8.	Biomarkers (Surrogate Marker)
9.	Enzymes
10.	Chromatin

Related Therapies and Procedures

1.	Therapeutics
2.	Quantum Dots (Quantum Dot)
3.	Punctures
4.	Ligation
5.	Drug Therapy (Chemotherapy)