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Prosthesis Failure

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Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.

Also Known As:

Prosthesis Migration; Failure, Prosthesis; Failures, Prosthesis; Loosening, Prosthesis; Loosenings, Prosthesis; Migration, Prosthesis; Migrations, Prosthesis; Prosthesis Failures; Prosthesis Loosenings; Prosthesis Migrations; Prosthesis Loosening

Networked: 157 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions
- Pathologic Processes: 4357
  - Postoperative Complications
    - Prosthesis Failure: 157
      - Implant Capsular Contracture: 6

Related Diseases

1.	Infection
2.	Pain (Aches)
3.	Osteolysis
4.	Osteoarthritis
5.	Inflammation

Experts

1.	Hu, Yihe: 3 articles (08/2015 - 06/2011)
2.	Li, Mingqing: 3 articles (08/2015 - 06/2011)
3.	Esposito, Marco: 3 articles (01/2013 - 01/2010)
4.	Morawietz, L: 3 articles (03/2008 - 01/2003)
5.	Krenn, V: 3 articles (03/2008 - 01/2003)
6.	Gehrke, T: 3 articles (03/2008 - 01/2003)
7.	Cannas, M: 3 articles (03/2004 - 03/2003)
8.	Renò, F: 3 articles (03/2004 - 03/2003)
9.	Xie, Jie: 2 articles (08/2015 - 01/2014)
10.	Li, Kanghua: 2 articles (06/2011 - 04/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Prosthesis Failure:

1.	TitaniumIBA 10/01/2003 - "There was an additional single incidence of prosthesis failure in the titanium group. " 07/01/2014 - "There was no dislocation, prosthesis loosening, dislocation, loosening of titanium cable, periprosthetic osteolysis, or other complications during the follow-up period. " 12/01/2005 - "Within the limits of this study, the following conclusions can be drawn: 1) Regardless of screw type, marginal misfit was higher for Ni-Cr-Be cylinders after casting, but within acceptable levels of fit; 2) The combination of gold cylinders with gold or titanium screws was the most effective to reduce marginal misfit; 3) Both screw types did not improve marginal fit of Ni-Cr-Be cylinders after overcastting, and 4) Although a 20Ncm torque improved marginal fit in all situations, its use is not recommended due to the increased risk of prosthesis failure. "
2.	GoldIBA 12/01/2005 - "Within the limits of this study, the following conclusions can be drawn: 1) Regardless of screw type, marginal misfit was higher for Ni-Cr-Be cylinders after casting, but within acceptable levels of fit; 2) The combination of gold cylinders with gold or titanium screws was the most effective to reduce marginal misfit; 3) Both screw types did not improve marginal fit of Ni-Cr-Be cylinders after overcastting, and 4) Although a 20Ncm torque improved marginal fit in all situations, its use is not recommended due to the increased risk of prosthesis failure. "
3.	Dental Porcelain (Porcelain)IBA 03/01/2012 - "Prosthesis failure was 25.2% (n = 16/66), with 12 porcelain fractures, 2 cement failures, and 2 framework fractures. " 06/01/2007 - "Our search strategy was as follows: Search 1: Partial fixed denture OR denture, partial, fixed OR denture, partial fixed OR dental porcelain OR metal ceramic alloys OR dental ceramic Search 2: Prosthesis failure OR dental restoration failure OR time factors OR survival analysis Search 3: Meta-analysis OR evaluation studies OR review OR clinical trial OR comparative study OR follow-up studies OR prospective studies OR clinical follow-up study OR clinical trial OR longitudinal studies Inclusion of searches 1, 2 and 3 and limits placed on the publication date starting on January 1, 1980, English language, and clinical studies involving humans resulted in a total of 684 articles. "
4.	UbiquitinIBA 07/01/2009 - "Small ubiquitin-like modifier 1 [corrected] mediates the resistance of prosthesis-loosening fibroblast-like synoviocytes against Fas-induced apoptosis." 07/01/2009 - "To study the expression of small ubiquitin-like modifier 1 (SUMO-1) in aseptic loosening of prosthesis implants and to investigate its role in regulating the susceptibility of prosthesis-loosening fibroblast-like synoviocytes (FLS) to Fas-induced apoptosis. "
5.	Metal Ceramic AlloysIBA 06/01/2007 - "Our search strategy was as follows: Search 1: Partial fixed denture OR denture, partial, fixed OR denture, partial fixed OR dental porcelain OR metal ceramic alloys OR dental ceramic Search 2: Prosthesis failure OR dental restoration failure OR time factors OR survival analysis Search 3: Meta-analysis OR evaluation studies OR review OR clinical trial OR comparative study OR follow-up studies OR prospective studies OR clinical follow-up study OR clinical trial OR longitudinal studies Inclusion of searches 1, 2 and 3 and limits placed on the publication date starting on January 1, 1980, English language, and clinical studies involving humans resulted in a total of 684 articles. "
6.	Polyethylene (Polythene)IBA 10/01/2010 - "Malalignment may contribute to early prosthesis failure through point loading and premature polyethylene wear. " 01/01/2009 - "Long-term follow-up is critical for patients with total joint replacement for early detection of occult polyethylene wear and prosthesis loosening. " 02/01/2007 - "It is widely recognized that polyethylene wear debris is one of the main causes of long-term prosthesis loosening. " 09/01/1999 - "Therefore, polyethylene wear was considered one of the major causes of osteolysis, but it was not directly associated with prosthesis loosening. " 11/01/1991 - "Two cases of dissociation of the metal-backed tibial component from its polyethylene articulating surface presented symptoms of prosthesis failure: persistent pain, swelling, sensations of instability, and gait difficulty. "
7.	CytokinesIBA 12/01/2006 - "Plasma cytokines as markers of aseptic prosthesis loosening." 12/01/2006 - "Our data suggest elevated plasma levels of proinflammatory cytokines may be useful as markers of bone resorption in the laboratory diagnosis of prosthesis loosening." 01/01/2001 - "Inhibition of osteoclastogenesis in vitro by OPG suggests that a low level of OPG with elevated bone resorbing cytokines contributes to periprosthetic osteolysis via osteolytic joint fluid, thus leading to THA prosthesis loosening." 01/01/2012 - "In conclusion, ginsenosides can reduce the levels of inflammatory cytokines produced by osteoblasts on induction with Ti particles and can prevent prosthesis loosening. " 01/01/2015 - "CGRP shows a time-dependent inhibitory effect on the secretion of osteolysis-associated pro-inflammatory cytokines, indicating an indirect anti-resorptive influence of the neuropeptide on both aseptic prosthesis loosening and bacterially induced bone resorption which might enhance the life time of total joint replacements."
8.	ultra-high molecular weight polyethylene (UHMWPE)IBA 04/01/2006 - "The tibial component of current knee prostheses made of ultra high molecular weight polyethylene (UHMWPE) has a high degree of wear that causes knee inflammation, prosthesis loosening and subsequent replacement in not more than 15 years. " 03/01/2003 - "To explore direct effects of UHMWPE oxidation on immunocompetent cells and their possible role in the prosthesis failure, peripheral blood cells (PBCs) have been grown for 24 and 48 h onto plastic (Ct), UHMWPE (PE) and heat oxidized UHMWPE (PEOx) discs. " 03/01/2004 - "Ultra-high molecular weight polyethylene (UHMWPE) is a biopolymer widely used in orthopaedic implants and its oxidation is considered as major responsible for inflammation and the prosthesis failure. " 08/01/2003 - "Ultra-high molecular weight polyethylene (UHMWPE), a biopolymer widely used in orthopaedic implants, is oxidized during gamma-ray sterilization; such surface oxidation is considered as major responsible for inflammation and prosthesis failure. "
9.	Polymethyl Methacrylate (Sol)IBA 07/08/2002 - "Prosthesis loosening is a major problem associated with the use of poly(methyl methacrylate) (PMMA) bone cement that may be related to a peri-implant vacuolisation commonly observed at bone-cement interface. " 01/01/2011 - "Using polymethylmethacrylate (PMMA) cement in cemented endoprostheses may cause heat necrosis and prosthesis failure due to the highly exothermic reaction. "
10.	Interleukin-10 (Interleukin 10)IBA 01/01/2002 - "The anti-inflammatory IL-10 was highly elevated only in cases with prosthesis loosening. " 10/01/2002 - "We found a negative correlation between the bone resorption marker (CTX) and IL-10 in cases with prosthesis loosening and a positive correlation between IL-10 and time-to-revision. "

Therapies and Procedures

1.	Prostheses and Implants (Prosthesis) 01/01/1995 - "[Macroscopic, histologic and ultrastructural study of 89 prostheses of anterior cruciate ligament excised because of prosthesis failure]." 09/01/2015 - "Aseptic loosening is the primary cause of cementless femoral prosthesis failure and is related to the primary stability of the cementless femoral prosthesis in the femoral cavity. " 08/01/2015 - "Radiographic results including stress shielding, subsidence of the stems, bone ingrowth and prosthesis loosening showed that prostheses were stably fixed postoperatively. " 07/01/2015 - "Late prosthesis failure occurred in 5 cases (1.4%); among these, redo TAVI was successfully carried out in 2 patients (0.6%) presenting with symptomatic prosthesis restenosis. " 01/01/2014 - "There was no prosthesis loosening or femoral prosthesis subsidence. "
2.	Arthroplasty 12/01/2012 - "This study investigates the use of an accelerated probabilistic framework for predicting the likely performance envelope of a device and applies it to femoral prosthesis loosening in cemented hip arthroplasty. " 11/25/2015 - "Aseptic loosening is the most common cause of prosthesis failure after total hip arthroplasty (THA). " 01/01/2013 - "In a prospective study, radiography and digital tomosynthesis were performed in 40 consecutive patients with total hip arthroplasty referred for suspect prosthesis loosening. " 11/01/2012 - "Prosthesis loosening is becoming more and more important due to increasing numbers of primary arthroplasty. " 01/01/2011 - "Although it has been suggested that women are less appropriate candidates for metal-on-metal arthroplasty, the mechanisms of prosthesis failure has not been fully explained. "
3.	Knee Prosthesis 09/01/2015 - "In this study, we aimed to evaluate the contribution of single-photon emission computerized tomography/computed tomography (SPECT/CT) to three-phase planar bone scintigraphy/SPECT in the assessment of aseptic and septic prosthesis loosening in patients with painful hip and knee prostheses. " 01/01/2010 - "20 patients with painful knee prosthesis underwent PET imaging to evaluate aseptic loosening / prosthesis infection of their knee prosthesis. " 11/01/2008 - "Intraoperative ibandronate reduced prosthesis migration after implantation of total knee prosthesis." 04/01/2006 - "The tibial component of current knee prostheses made of ultra high molecular weight polyethylene (UHMWPE) has a high degree of wear that causes knee inflammation, prosthesis loosening and subsequent replacement in not more than 15 years. "
4.	Dental Restoration Failure 06/01/2007 - "Our search strategy was as follows: Search 1: Partial fixed denture OR denture, partial, fixed OR denture, partial fixed OR dental porcelain OR metal ceramic alloys OR dental ceramic Search 2: Prosthesis failure OR dental restoration failure OR time factors OR survival analysis Search 3: Meta-analysis OR evaluation studies OR review OR clinical trial OR comparative study OR follow-up studies OR prospective studies OR clinical follow-up study OR clinical trial OR longitudinal studies Inclusion of searches 1, 2 and 3 and limits placed on the publication date starting on January 1, 1980, English language, and clinical studies involving humans resulted in a total of 684 articles. "
5.	Antibiotic Prophylaxis 01/01/2013 - "No conclusive information can be derived from the only trial that compared three different durations of antibiotic prophylaxis since no event (implant/prosthesis failures, infections or adverse events) occurred in any of the 25 participants included in each study group. "