Prostaglandins

A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.

Also Known As:

Networked: 17100 relevant articles (479 outcomes, 1554 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Narumiya, Shuh: 78 articles (01/2022 - 01/2002)
2.	Urade, Yoshihiro: 33 articles (01/2021 - 06/2002)
3.	Sugimoto, Yukihiko: 29 articles (01/2021 - 01/2002)
4.	Maruyama, Takayuki: 27 articles (01/2022 - 01/2002)
5.	DuBois, Raymond N: 24 articles (12/2021 - 05/2003)
6.	Milne, Ginger L: 23 articles (08/2022 - 06/2006)
7.	Doré, Sylvain: 22 articles (01/2020 - 05/2003)
8.	Levine, Jon D: 21 articles (01/2022 - 10/2002)
9.	Dannenberg, Andrew J: 21 articles (01/2019 - 08/2002)
10.	Breyer, Richard M: 20 articles (12/2020 - 03/2003)

Related Diseases

1.	Inflammation (Inflammations) 11/01/2002 - "In addition to their proinflammatory activities, prostaglandins recently have been shown to be beneficial in the resolution of tissue injury and inflammation. " 09/01/2012 - "Human immunodeficiency virus (HIV)-induced inflammation, and its consequences within the central nervous system (CNS), must be countered by multiple pharmacologic agents, and 15-deoxy-Δ(12,14) -prostaglandin J(2) (15d-PGJ2) may hold promise in the treatment of pathologies associated with this inflammatory response. " 01/01/2011 - "Ocular irritation of the developed formulation was also checked by HET-CAM test and efficacy of the developed formulation against prostaglandin-induced ocular inflammation in rabbit eye was determined. " 11/16/2023 - "Our study confirmed that FCS can directly promote gut microbiota to synthesize inflammatory factor prostaglandins, which provides new insights and directions for the treatment of FCS-induced metabolic disorders and inflammation." 11/01/2023 - "Studies have confirmed that prostaglandins and their receptors play important roles in the occurrence and development of PAH through vasoconstriction, vascular smooth muscle cell proliferation and migration, inflammation, and extracellular matrix remodeling. "
2.	Pain (Aches) 08/01/1990 - "However, overall pain experience and morbidity were not significantly improved suggesting that there was no clinical benefit derived from interference with tissue prostaglandin synthesis at the time of surgery." 01/01/2022 - "Both BTX-A and prostaglandins helped in the healing and pain control of DUs. " 06/25/2016 - "This study was designed to investigate the contribution of prostaglandins to the maintenance of inflammatory pain. " 11/01/1999 - "This study confirms that COX-2 derived prostanoids are important clinical mediators of pain and other symptoms of knee OA and that inhibition of COX-1 is not required to provide clinical benefit." 06/01/1983 - "It is suggested on the basis of animal studies that this effect may be mediated by release of prostaglandins as well as indirectly via pain relief."
3.	Neoplasms (Cancer) 04/01/2002 - "Inhibition of prostaglandin synthesis may be beneficial in human malignancy. " 04/13/2022 - "One of the consequences of the study is an assumption of prostanoid-dependent (or independent) tumor phenotypes. " 08/20/2019 - "Recent studies showed that the activation of prostaglandin (PG) receptor EP1 promotes cell migration and invasion in different cancers. " 01/01/2019 - "Accumulating studies showed that the activation of prostaglandin (PG) receptor EP1 promotes cell migration and invasion in different cancers, which could be inverted by blocking the EP1 receptor. " 10/01/2018 - "Previous studies utilizing immune compromised mice have shown that blocking prostaglandin synthesis reduces PPBC tumor progression in a tumor cell extrinsic manner. "
4.	Ulcer 01/01/1996 - "A prostanoid-induced increase in ulcer flux could be a rationale for the improved wound healing. " 09/15/2014 - "Clinical studies indicate that prostaglandins of E class (PGEs) may promote healing of tissue injury e.g., gastroduodenal and dermal ulcers. " 01/01/1994 - "Metaanalyses of therapeutic trials have indicated that time to first relapse was longer after ulcer healing with prostaglandins (PG) than after healing with H2-receptor blockers, which might be due to a different effect of the two treatments on parietal cell sensitivity. " 12/01/1990 - "The mechanism of ulcer healing by prostaglandins and the clinical relevance of antiulcer effects of drugs demonstrated in acute studies with animals were also controversial. " 02/01/1986 - "Several studies have provided quantitative evidence of disturbed prostaglandin metabolism in some forms of ulcer disease. "
5.	Pulmonary Arterial Hypertension 01/01/2022 - "The earliest clinical studies of prostanoid treatment in pulmonary arterial hypertension demonstrated an important link between lowering mean pulmonary arterial pressure (or pulmonary vascular resistance) and improved survival. " 01/01/2020 - "Prostanoid treatment in patients with severe pulmonary arterial hypertension (PAH) has been proven safe and effective. " 04/01/2020 - "Parenteral prostanoids are effective for improving outcomes in patients with pulmonary arterial hypertension. " 07/01/2007 - "Prostanoids have been shown to improve exercise tolerance, hemodynamics and quality of life in patients with pulmonary arterial hypertension (PAH). " 12/01/2005 - "In pulmonary arterial hypertension, prostanoid inhalation has been found to improve pulmonary hemodynamics, right ventricular function, gas exchange, and clinical outcome. "

Related Drugs and Biologics

1.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
2.	Prostaglandins
3.	Indomethacin (Indometacin)
4.	Prostaglandins E
5.	Dinoprostone (PGE2)
6.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
7.	Leukotrienes
8.	Aspirin (Acetylsalicylic Acid)
9.	Alprostadil (Muse)
10.	Nitric Oxide (Nitrogen Monoxide)

Related Therapies and Procedures

1.	Therapeutics
2.	Surgical Amputation (Amputations)
3.	Analgesia
4.	Anesthesia
5.	Drug Therapy (Chemotherapy)