Propylthiouracil

A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)

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Networked: 1295 relevant articles (65 outcomes, 99 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Gao, Ying: 13 articles (08/2012 - 06/2003)
2.	Laurberg, Peter: 9 articles (11/2015 - 06/2007)
3.	Zhao, Ming-Hui: 9 articles (08/2012 - 10/2005)
4.	Rivkees, Scott A: 8 articles (06/2015 - 01/2009)
5.	Zhao, Ming-hui: 8 articles (01/2013 - 06/2003)
6.	Shibutani, Makoto: 7 articles (01/2016 - 12/2007)
7.	Tsakiris, Stylianos: 6 articles (08/2015 - 06/2005)
8.	Zarros, Apostolos: 6 articles (08/2015 - 06/2005)
9.	Serakides, Rogéria: 6 articles (06/2014 - 04/2004)
10.	Chen, Min: 6 articles (01/2013 - 01/2007)

Related Diseases

1.	Hyperthyroidism 03/01/1980 - "Hyperthyroidism occurred at the age of 3 10/12 years and was treated successfully with propylthiouracil for 4 years. " 12/01/1984 - "Hyperthyroidism was effectively treated with propylthiouracil (PTU) with slightly increased basal TSH level and normal response of TSH to TRH. " 12/01/2006 - "[The effect of propylthiouracil on the efficacy of radioiodine (I-131) therapy in graves hyperthyroidism]." 10/01/1987 - "Remission in children with hyperthyroidism treated with propylthiouracil. " 04/01/2012 - "The aim of this study is to investigate the CIMT in patients with Graves' hyperthyroidism and the effect of propylthiouracil (PTU) therapy on CIMT. "
2.	Hypothyroidism 10/01/1995 - "Propylthiouracil (PTU)-induced hypothyroidism in male rats produced a highly significant reduction in NOS gene transcripts in the PVN and SON, as assessed by quantitative in situ hybridization histochemistry with a specific oligodeoxynucleotide probe. " 02/01/1999 - "Propylthiouracil (PTU), administered to induce hypothyroidism, resulted in a significant reduction m the thyroid and brain weight of neonatal rats. " 12/01/2000 - "This study compared the efficacy of heat and cold stress to identify thermoregulatory deficits in rats subjected to borderline and overt hypothyroidism via subchronic exposure to propylthiouracil (PTU). " 08/01/2015 - "The current study evaluated the effects of gestational and/or lactational maternal exposure to propylthiouracil (PTU)-induced hypothyroidism (as a suggestive multilevel experimental approach to the study of hypothyroidism-induced changes that has been developed and characterized by the authors) on crucial brain enzyme activities of 21-day-old Wistar rat offspring in a CNS region-specific manner. " 02/01/2015 - "The aim of the present study was to shed more light on the effects of gestational and/or lactational maternal exposure to propylthiouracil (PTU)-induced hypothyroidism as a multilevel experimental approach to the study of hypothyroidism-induced changes on crucial brain enzyme activities of 21-day-old Wistar rat offspring in a brain region-specific manner. "
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 11/01/2011 - "Therapeutic efficacy and safety of propylthiouracil in psoriasis: an open-label study." 03/01/2015 - "Propylthiouracil (PTU), an anti-thyroid thioureylene, has been shown to be effective in chronic plaque psoriasis. " 11/01/2011 - "In this scenario, propylthiouracil (PTU), an antithyroid thioureylene has been shown to be effective in psoriasis which satisfies the above criteria. " 12/01/2003 - "Propylthiouracil (PTU), an antithyroid thioureylene with immunomodulatory properties, has been shown to be effective in the therapy of patients with plaque psoriasis. " 12/01/2004 - "This study examined p16 expression in biopsy samples of eight patients with plaque psoriasis given 300 mg of propylthiouracil in divided doses for 3 months. "
4.	Graves Disease (Basedow Disease) 01/01/2011 - "Successful remission of Evans syndrome associated with Graves' disease by using propylthiouracil monotherapy." 03/01/1979 - "In Graves' disease (including those patients on propylthiouracil) in remission and treated with 131I, the correlation between TDA and hTSA was not significant (r = 0.309; P greater than 0.1); even when the procedures were compared in the untreated group alone, there was no significant correlation between the two activities (r = 0.309, P greater than 0.1). " 01/01/2009 - "Predictors of time to remission and treatment failure in patients with Graves' disease treated with propylthiouracil." 07/01/2001 - "One patient with SAA, which developed during treatment with propylthiouracil for Graves' disease, underwent allogeneic BMT and showed evidence of Graves' disease remission following BMT. " 06/01/1999 - "Therapy with propylthiouracil (PTU) improved fetal thyroid function tests as well as the clinical signs of fetal Graves' disease. "
5.	Thyrotoxicosis 01/01/1979 - "The fetal thyrotoxicosis responded well to propylthiouracil given to the mother. " 11/01/1981 - "Preliminary dose-response studies with propylthiouracil suggest a peak therapeutic serum concentration of above 4 micrograms/ml in the treatment of thyrotoxicosis. " 03/01/1978 - "The present study suggests that with careful attention, pregnant women with thyrotoxicosis can be treated with propylthiouracil without interfering with subsequent intellectual development in the offspring." 11/01/2014 - "When the patient presented in our clinic, he had thyrotoxicosis and was using propylthiouracil. " 11/01/2010 - "The patient developed thyrotoxicosis 3 months after commencing treatment, which required treatment with propylthiouracil. "

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Related Therapies and Procedures

1.	Thyroidectomy
2.	Oral Administration
3.	Aftercare (After-Treatment)
4.	Nutritional Support (Artificial Feeding)
5.	Injections