Properdin

A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.

Also Known As:

Networked: 373 relevant articles (6 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Song, Wen-Chao: 9 articles (08/2015 - 01/2008)
2.	Miwa, Takashi: 6 articles (08/2015 - 01/2008)
3.	Schwaeble, Wilhelm J: 6 articles (07/2015 - 03/2008)
4.	Stover, Cordula M: 6 articles (07/2015 - 03/2008)
5.	Stover, Cordula: 6 articles (08/2014 - 04/2010)
6.	Gullipalli, Damodar: 4 articles (08/2015 - 01/2013)
7.	Sato, Sayaka: 4 articles (08/2015 - 01/2013)
8.	Meri, Seppo: 4 articles (01/2012 - 05/2005)
9.	Byrne, Simon: 3 articles (01/2015 - 01/2014)
10.	Lesher, Allison M: 3 articles (10/2014 - 01/2013)

Related Diseases

1.	Infection 04/08/2014 - "Low-dose recombinant properdin provides substantial protection against Streptococcus pneumoniae and Neisseria meningitidis infection." 06/01/2009 - "This study is the first to show a significant association between properdin deficiency and recurrent infections." 12/01/2008 - "This study concluded that patients with low expression of properdin should be advised to take extensive preventive measures and seek early management with appropriate treatments against infection." 05/01/1958 - "Experimental studies of the in vivo relationships of the properdin system to resistance to infection." 08/01/2014 - "In vitro analyses of splenocytes and bone marrow-derived myeloid cells support the view that the opposing outcomes of properdin-deficient and wildtype mice in these two infection models is likely to be due to a skewing of macrophage activity to an M2 phenotype in the properdin-deficient mice. "
2.	Arthritis (Polyarthritis) 01/01/2012 - "Our data show that the active involvement of properdin in arthritis is related to an increased proinflammatory cytokine production and RANKL expression on immune cells and to a stimulation of the RANKL-dependent osteoclast differentiation." 10/01/2010 - "Ab neutralization of properdin in WT mice similarly ameliorated arthritis development, whereas reconstitution of properdin-null mice with exogenous properdin restored arthritis sensitivity. " 01/15/1976 - "The C3-activator fragment of the properdin complex was identified in fresh serum samples obtained from two of the three patients with circulating cryoprotein complexes and arthritis. " 01/01/2012 - "Abrogated RANKL expression in properdin-deficient mice is associated with better outcome from collagen-antibody-induced arthritis." 10/01/2010 - "Properdin deficiency rescued mice from AP complement–mediated embryonic lethality caused by deficiency of the membrane complement regulator Crry and markedly reduced disease severity in the K/BxN model of arthritis. "
3.	Reperfusion Injury 10/01/2014 - "Renal ischemia-reperfusion injury in the Crry conditional knockout mice was prevented by blocking C3 and C5 activation using an anti-properdin or anti-C5 monoclonal antibody (mAb), respectively. " 04/01/2013 - "Blocking properdin, the alternative pathway, and anaphylatoxin receptors ameliorates renal ischemia-reperfusion injury in decay-accelerating factor and CD59 double-knockout mice."
4.	Convalescence 12/01/1977 - "Serum properdin titers were decreased in 14 patients at the time of admission, in 12 patients 2 hours after treatment, and in none during convalescence. " 09/01/1991 - "A decrease in the levels of complement and properdin during convalescence is seemingly linked with their consumption for the formation of immune complexes, eliminated from the body."
5.	Kidney Diseases (Kidney Disease) 01/01/2013 - "Mutations in fH associate with several human kidney diseases, but whether inhibiting properdin would be beneficial in these diseases is unknown. "

Related Drugs and Biologics

1.	Complement System Proteins (Complement)
2.	Antigen-Antibody Complex (Immune Complex)
3.	Lipopolysaccharides
4.	Anaphylatoxins
5.	CD55 Antigens (Decay Accelerating Factor)
6.	Collagen
7.	Complement Factor B (Factor B)
8.	Immunoglobulin A (IgA)
9.	Immunoglobulin G (IgG)
10.	Antibodies

Related Therapies and Procedures

1.	Homologous Transplantation (Allograft)
2.	Radiotherapy
3.	Aftercare (After-Treatment)
4.	Transplants (Transplant)
5.	Ligation