Propanil

08/01/2016 - "This simple bedside test was associated with increased use of the first line treatment for propanil poisoning and improved survival. "
02/16/2009 - "The objective of this study is to describe the clinical outcomes and kinetics of propanil following acute intentional self-poisoning. "
06/01/2022 - "We describe a case of severe Propanil poisoning who was successfully treated in a peripheral hospital with available facilities."
06/01/2022 - "A New Treatment Approach for Acute Propanil Poisoning: A Case Report."
01/01/2022 - "Clinical characteristics, treatment and outcomes of acute propanil poisoning in a 7-year retrospective cohort study."

08/01/2016 - "Toxicity from propanil is largely due to methemoglobinemia. "
08/01/2008 - "The reported toxicities for propanil exposure include methemoglobinemia, immunotoxicity, and nephrotoxicity. "
01/01/2022 - "Median time to onset of methemoglobinemia and hemolysis after propanil ingestion was 5.5 and 48 h, respectively. "
06/01/2020 - "Propanil can produce methemoglobinemia, hemolytic anemia, hepatotoxicity, metabolic disorder and nephrotoxicity. "
03/15/1990 - "Methemoglobinemia produced by exposure to the herbicide propanil (3,4-dichloropropionanilide) is thought to be mediated by toxic metabolites formed during the hepatic clearance of the parent compound. "

05/01/1989 - "Contact hypersensitivity response (CHR), blastogenic response to T- and B-cell-specific mitogens, and mixed lymphocyte reaction (MLR) were significantly depressed only in propanil-treated animals at 400 mg/kg. However, the number of splenic antibody-producing cells was also significantly depressed in a dose-dependent manner at the lower doses of 50, 100, and 200 mg/kg. In addition, a significant reduction in the thymus weight and an increase in absolute and relative spleen weight were also measured in animals treated with 200 and 400 mg/kg. The increase in spleen weight also showed a concomitant rise in spleen cellularity. "

01/15/1999 - "In the present study, we investigated the effect of propanil on IL-2 expression and production in the murine lymphoma T cell line, EL-4. "

07/28/2000 - "Studies to determine resistance to infection by the intracellular bacterium Listeria monocytogenes after exposure to propanil were also conducted. "
07/28/2000 - "Initial resistance to the infection was not affected by exposure to propanil. "
07/28/2000 - "These results demonstrate that in vivo exposure to propanil during a bacterial infection suppresses the subsequent in vitro production of cytokines but that the endogenous levels are not affected during the initial stages of infection."