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Propafenone (Rythmol)

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An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.

Also Known As:

Rythmol; SA 79; Abbott Brand of Propafenone Hydrochloride; Aliud Brand of Propafenone Hydrochloride; Alpharma Brand of Propafenone Hydrochloride; Apo-Propafenone; Apotex Brand of Propafenone Hydrochloride; Arythmol; Azupharma Brand of Propafenone Hydrochloride; Baxarytmon; Cuxafenon; Fenoprain; Hexal Brand of Propafenone; Juta Brand of Propafenone Hydrochloride; Jutanorm; Kendrick Brand of Propafenone Hydrochloride; Knoll Brand of Propafenone Hydrochloride; Merck dura Brand of Propafenone Hydrochloride; Nistaken; Norfenon; Pintoform; Prolecofen; Propafenon AL; Propafenon Hexal; Propafenon Minden; Propafenone Hydrochloride; Propafenone Hydrochloride, (R)-Isomer; Propafenone Hydrochloride, (S)-Isomer; Propafenone, (+-)-Isomer; Propafenone, (R)-Isomer; Propafenone, (S)-Isomer; Propamerck; Q-Pharm Brand of Propafenone Hydrochloride; Rytmo-Puren; Rytmogenat; Rytmonorm; SA-79; TAD Brand of Propafenone Hydrochloride; Hydrochloride, Propafenone; SA79; 1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-

Networked: 676 relevant articles (142 outcomes, 122 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Ketones: 431
  - Propiophenones
    - Propafenone: 676

Experts

1.	Lafuente-Lafuente, Carmelo: 4 articles (01/2015 - 04/2006)
2.	Boriani, Giuseppe: 4 articles (04/2010 - 01/2002)
3.	Bergmann, Jean-François: 3 articles (01/2015 - 04/2006)
4.	Aragon, Martin: 3 articles (01/2014 - 10/2013)
5.	Trivi, Marcelo: 3 articles (01/2014 - 10/2013)
6.	Conde, Diego: 3 articles (01/2014 - 10/2013)
7.	Costabel, Juan Pablo: 3 articles (01/2014 - 10/2013)
8.	Dorian, Paul: 3 articles (01/2011 - 09/2003)
9.	Martignani, Cristian: 3 articles (04/2010 - 01/2002)
10.	Biffi, Mauro: 3 articles (04/2010 - 01/2002)

Related Diseases

1.	Atrial Fibrillation 06/01/1987 - "Furthermore, propafenone caused a marked decrease in peak ventricular rate during atrial fibrillation. " 03/01/1996 - "Furthermore, the percentage decrease of ventricular rate during atrial fibrillation was significantly greater in patients with propafenone (-25 +/- 4% versus -8 +/- 3%, P < 0.01). " 12/15/2002 - "We report a double-blind, multicenter, multinational, placebo-controlled, and well-controlled trial to prove that the sustained-release (SR) formulation of propafenone is superior to placebo in preventing symptoms of paroxysmal atrial fibrillation (AF). " 03/01/2000 - "Propafenone is an effective and safe antiarrhythmic drug for converting paroxysmal and/or recent-onset atrial fibrillation of various origins with a more limited efficacy in chronic atrial fibrillation." 01/01/1995 - "The two drugs were equally effective in converting postoperative atrial fibrillation and/or flutter after 24 h although propafenone was superior within the first hour."
2.	Tachycardia (Tachyarrhythmias) 12/01/2012 - "In patients with non-inducible AVNRT, but without complete ventriculo-atrial block, propafenone was more effective in patients with shorter echo zone of tachycardia." 12/01/2012 - "In patients with non-inducible tachycardia, complete ventriculo-atrial block can be used as an electrophysiological predictor of the efficacy of propafenone oral therapy in the prevention of tachycardia. " 12/01/2012 - "Group A had significantly lower incidence of tachycardia than group B (95% vs 70.8%, P=0.038), and complete ventriculo-atrial block predicted the efficacy of propafenone oral therapy in the prevention of tachycardia (sensitivity 87.5%, specificity 52.8%, positive predictive value 95%, negative predictive value 29.2%). " 01/01/1995 - "Propafenone is a potent antiarrhythmic agent effective in either supraventricular or ventricular tachyarrhythmias. " 04/01/1990 - "Seven of the 13 children (53.8%) with ventricular ectopics, all three children with paroxysmal re-entry atrioventricular tachycardia, and two of the three children with paroxysmal atrial tachycardia were treated successfully with propafenone. "
3.	Cardiac Arrhythmias (Arrythmia) 06/01/1992 - "A younger age, low spontaneous arrhythmia variability, and particularly a low titration dose were the best predictors of the short and long term efficacy of propafenone. " 12/15/2002 - "There was a significant reduction in average heart rate during the first recurrence of symptomatic arrhythmia after day 5 in the low-dose propafenone group compared with placebo. " 08/01/1987 - "In junctional arrhythmia propafenone was certainly effective but unpredictably so (3 good results, 2 fair results, 4 failures). " 11/01/2002 - "Elevated plasma concentration is consistent with better efficacy of propafenone in patients with ventricular arrhythmia." 06/01/1987 - "Electrophysiologic testing identified the patient's arrhythmia, and demonstrated that it improved with intravenous propafenone, a new type 1C antiarrhythmic medication. "
4.	Ventricular Tachycardia 03/01/1986 - "In 19 cases of ventricular tachycardia, propafenone proved to be efficacious in 3 out of 5 cases presenting rapid discharges and in 7 out of 14 patients with continuous arrhythmias, notably those with a catecholaminergic component. " 12/01/1988 - "Propafenone is effective in treating ventricular tachycardia and in suppressing premature ventricular complexes (PVCs). " 11/14/1984 - "Propafenone was also effective in controlling couplets and nonsustained ventricular tachycardia. " 11/01/1990 - "Efficacy of propafenone in preventing ventricular tachycardia: inverse correlation with rate-related prolongation of conduction time." 10/01/1985 - "Propafenone eliminated all exercise provocable ventricular tachycardia. "
5.	Supraventricular Tachycardia 07/01/1994 - "In addition, propafenone is very effective in young patients with supraventricular tachycardia based on enhanced abnormal automaticity. " 06/01/1989 - "In conclusion, propafenone is very effective in the control of paroxysmal supraventricular tachycardia; intravenous propafenone can predict the efficacy of oral therapy." 06/01/1989 - "The authors studied the efficacy of intravenous (IV) (1.5-2 mg/kg) and oral propafenone (450 to 900 mg/day) in 16 patients with paroxysmal, sustained, recurrent supraventricular tachycardia (SVT). " 11/01/2010 - "Propafenone, an antiarrhythmic drug that is effective for treating supraventricular tachycardias, can induce well-known proarrhythmic and systemic adverse effects. " 10/16/1998 - "Thus, propafenone is effective in terminating supraventricular tachycardias and AF in the vast majority of patients. "

Related Drugs and Biologics

1.	Flecainide (Tambocor)
2.	Amiodarone (Amiodarona)
3.	Sotalol (Sotalol Hydrochloride)
4.	Quinidine (Chinidin)
5.	Disopyramide (Norpace)
6.	Procainamide (Procan)
7.	ibutilide (Corvert)
8.	Mexiletine (Mexitil)
9.	Digoxin (Digitek)
10.	Cytochrome P-450 CYP2D6 (CYP2D6)

Related Therapies and Procedures

1.	Electric Countershock (Cardioversion)
2.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
3.	Oral Administration
4.	Fontan Procedure (Fontan Operation)
5.	Intravenous Infusions