Propafenone (Rythmol)

An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.

Also Known As:

Rythmol; SA 79; Apo-Propafenone; Arythmol; Baxarytmon; Cuxafenon; Fenoprain; Jutanorm; Nistaken; Norfenon; Pintoform; Prolecofen; Propafenon AL; Propafenon Hexal; Propafenon Minden; Propafenone Hydrochloride; Propafenone Hydrochloride, (R)-Isomer; Propafenone Hydrochloride, (S)-Isomer; Propafenone, (+-)-Isomer; Propafenone, (R)-Isomer; Propafenone, (S)-Isomer; Propamerck; Rytmo-Puren; Rytmogenat; Rytmonorm; SA-79; Hydrochloride, Propafenone; SA79; 1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-

Networked: 800 relevant articles (151 outcomes, 145 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 140
- Ketones: 2712
  - Propiophenones: 1
    - Propafenone: 800

Experts

1.	Boriani, Giuseppe: 5 articles (12/2023 - 01/2002)
2.	Lafuente-Lafuente, Carmelo: 5 articles (01/2019 - 04/2006)
3.	Capucci, Alessandro: 4 articles (01/2018 - 01/2002)
4.	Aragon, Martin: 4 articles (01/2014 - 08/2013)
5.	Conde, Diego: 4 articles (01/2014 - 08/2013)
6.	Costabel, Juan Pablo: 4 articles (01/2014 - 08/2013)
7.	Trivi, Marcelo: 4 articles (01/2014 - 08/2013)
8.	Balik, M: 3 articles (05/2024 - 10/2017)
9.	Maly, M: 3 articles (05/2024 - 10/2017)
10.	Waldauf, P: 3 articles (05/2024 - 10/2017)

Related Diseases

1.	Atrial Fibrillation 06/01/1987 - "Furthermore, propafenone caused a marked decrease in peak ventricular rate during atrial fibrillation. " 03/01/1996 - "Furthermore, the percentage decrease of ventricular rate during atrial fibrillation was significantly greater in patients with propafenone (-25 +/- 4% versus -8 +/- 3%, P < 0.01). " 12/15/2002 - "We report a double-blind, multicenter, multinational, placebo-controlled, and well-controlled trial to prove that the sustained-release (SR) formulation of propafenone is superior to placebo in preventing symptoms of paroxysmal atrial fibrillation (AF). " 10/01/1997 - "Propafenone was more effective in patients with acute (<72 h) atrial fibrillation (64.5%). " 01/01/1995 - "The two drugs were equally effective in converting postoperative atrial fibrillation and/or flutter after 24 h although propafenone was superior within the first hour."
2.	Ventricular Tachycardia 01/01/1995 - "Propafenone is a potent antiarrhythmic agent effective in either supraventricular or ventricular tachyarrhythmias. " 03/01/1986 - "In 19 cases of ventricular tachycardia, propafenone proved to be efficacious in 3 out of 5 cases presenting rapid discharges and in 7 out of 14 patients with continuous arrhythmias, notably those with a catecholaminergic component. " 07/01/1991 - "Acute and long-term efficacy of propafenone in patients with sustained ventricular tachyarrhythmias: assessment with programmed ventricular stimulation." 12/01/1988 - "Propafenone is effective in treating ventricular tachycardia and in suppressing premature ventricular complexes (PVCs). " 03/01/1987 - "Propafenone was considered as effective when a well-defined quantitative and qualitative reduction of ventricular tachyarrhythmias was reached. "
3.	Tachycardia (Tachyarrhythmias) 12/01/2012 - "In patients with non-inducible AVNRT, but without complete ventriculo-atrial block, propafenone was more effective in patients with shorter echo zone of tachycardia." 04/01/1990 - "Seven of the 13 children (53.8%) with ventricular ectopics, all three children with paroxysmal re-entry atrioventricular tachycardia, and two of the three children with paroxysmal atrial tachycardia were treated successfully with propafenone. " 03/01/2010 - "The main outcome measures were safety and efficacy of 2 mg/kg intravenous propafenone in tachycardia termination and re-induction. " 08/01/1995 - "Although propafenone is effective in the acute management of junctional reentrant tachycardias, the availability of safer drugs precludes its routine use for these arrhythmias. " 09/15/1991 - "Propafenone was partially or completely effective in 3 of 4 patients with chaotic atrial tachycardia. "
4.	Cardiac Arrhythmias (Arrythmia) 06/01/1992 - "A younger age, low spontaneous arrhythmia variability, and particularly a low titration dose were the best predictors of the short and long term efficacy of propafenone. " 12/15/2002 - "There was a significant reduction in average heart rate during the first recurrence of symptomatic arrhythmia after day 5 in the low-dose propafenone group compared with placebo. " 08/01/1987 - "In junctional arrhythmia propafenone was certainly effective but unpredictably so (3 good results, 2 fair results, 4 failures). " 11/01/2002 - "Elevated plasma concentration is consistent with better efficacy of propafenone in patients with ventricular arrhythmia." 06/01/1987 - "Electrophysiologic testing identified the patient's arrhythmia, and demonstrated that it improved with intravenous propafenone, a new type 1C antiarrhythmic medication. "
5.	Atrial Flutter (Flutter, Atrial) 09/15/1991 - "Propafenone was effective in 33 of 37 patients (89%); atrial flutter was controlled in 2 patients, ventricular ectopy was suppressed in 1 of 2 patients. " 08/01/1991 - "Propafenone is effective in greater than 50% of patients with paroxysmal atrial flutter or fibrillation, resistant to other antiarrhythmic agents. " 02/01/1996 - "We can conclude that propafenone is effective and safe when used with transesophageal pacing in the termination of atrial flutter. " 12/15/1995 - "We conclude that propafenone is effective and safe when used with transesophageal pacing in the termination of atrial flutter. " 02/15/1997 - "Efficacy of intravenous propafenone in termination of atrial flutter by overdrive transesophageal pacing previously ineffective."

Related Drugs and Biologics

1.	Amiodarone (Amiodarona)
2.	Flecainide (Tambocor)
3.	Sotalol (Sotalol Hydrochloride)
4.	Quinidine (Chinidin)
5.	Anti-Arrhythmia Agents
6.	Disopyramide (Norpace)
7.	Procainamide (Procan)
8.	ibutilide (Corvert)
9.	Mexiletine (Mexitil)
10.	Digoxin (Digitek)

Related Therapies and Procedures

1.	Therapeutics
2.	Electric Countershock (Cardioversion)
3.	Oral Administration
4.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
5.	Drug Therapy (Chemotherapy)