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Promethazine (Promet)

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A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.

Also Known As:

Promet; Phenergan; Prometazin; Atosil; Diphergan; Diprazin; Isopromethazine; Phenargan; Phensedyl; Pipolfen; Pipolphen; Promethazine Hydrochloride; Prothazin; Pyrethia; Remsed; Rumergan; Hydrochloride, Promethazine; Proazamine; 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-

Networked: 477 relevant articles (44 outcomes, 69 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Gan, Tong J: 3 articles (11/2009 - 02/2005)
2.	Habib, Ashraf S: 3 articles (11/2009 - 02/2005)
3.	Kan, Kelvin K W: 3 articles (12/2008 - 12/2003)
4.	Rudd, John A: 3 articles (12/2008 - 12/2003)
5.	Kristal, Bruce S: 3 articles (01/2008 - 01/2004)
6.	Stavrovskaya, Irina G: 3 articles (01/2008 - 01/2004)
7.	Van de Heyning, Paul H: 2 articles (12/2015 - 06/2014)
8.	Wuyts, Floris L: 2 articles (12/2015 - 06/2014)
9.	Weerts, Aurélie P: 2 articles (12/2015 - 06/2014)
10.	Grant, Gary D: 2 articles (12/2014 - 09/2013)

Related Diseases

1.	Nausea 02/01/2015 - "Ninety-seven percent of subjects reported total relief of nausea with a single administration of promethazine at either dose. " 07/01/2003 - "Thus, promethazine neither reduced the nausea associated with RWR, nor retarded or hastened habituation. " 08/01/1999 - "The incidence of nausea was not altered by prophylactic administration of 0.6 mg x kg(-1) promethazine i.m. " 10/01/1995 - "This combination was also more efficient in reducing the incidence of nausea (to 25%) and nausea episodes than promethazine along (P < 0.05). " 06/01/1994 - "Another experimental group also received promethazine and was allowed to make as many head movements as they could, before reaching nausea, up to 800. "
2.	Vomiting 09/20/2011 - "In conclusion, daily linear acceleration training and promethazine could prevent the hypergravity-induced vomiting episodes." 09/20/2011 - "Higher dose of bolus injection of promethazine (50mg/kg, i.p.) completely abolished the vomiting episodes, although the animals were drowsy and sedated due to side effects. " 03/01/1993 - "Following intramuscular (IM) promethazine on flight day 1, the scores were used to determine if the crewmembers were "sick" or "not sick" on flight day 2. On the basis of the scoring criteria, any subject with a score adding to greater than three, with any severe symptom, or with vomiting was defined as "sick." The comparison showed that 25% of crewmembers treated with IM promethazine were "sick" on flight day 2, compared to 50% of crewmembers who did not receive promethazine (p = 0.046). " 03/01/2010 - "The initial examination of the efficacy of low-dose promethazine for the treatment of nausea and vomiting in the hospitalized elderly." 08/01/1999 - "To determine the incidence of post-discharge nausea and vomiting (PDNV) following outpatient laparoscopic procedures in women, and to assess the efficacy of the prophylactic administration of promethazine prior to discharge from hospital. "
3.	Postoperative Nausea and Vomiting (PONV) 02/01/2015 - "Promethazine 6.25 mg is as effective in controlling PONV as promethazine 12.5 mg, while resulting in less sedation." 08/01/2015 - "Is Promethazine 6.25 mg Intravenous Dose Really Ideal to Treat Postoperative Nausea and Vomiting?" 02/01/2015 - "In a double-blind, randomized controlled trial (n = 120), 59 subjects received promethazine 6.25 mg and 61 subjects received promethazine 12.5 mg to treat PONV. " 02/01/2015 - "A comparison of two differing doses of promethazine for the treatment of postoperative nausea and vomiting." 11/01/1999 - "During the 24-hour period, the incidence of postoperative nausea and vomiting was reduced from 74% (placebo) to 39% (promethazine; p = 0.03) and 29% (combination; p = 0.003). "
4.	Motion Sickness (Airsickness) 10/01/2000 - "Autogenic-feedback training exercise is superior to promethazine for control of motion sickness symptoms." 10/01/2000 - "An earlier study tested the effects of promethazine on cognitive and psychomotor performance and motion sickness tolerance in a rotating chair. " 01/01/2015 - "The results of experimental clinical testing of the antinaupathia action of as new compounds, so motion sickness medications (promethazine, ikaron-1 etc.) are presented. " 01/01/2008 - "Development of a melting tablet containing promethazine HCl against motion sickness." 03/01/2007 - "Microcapsule-gel formulation of promethazine HCl for controlled nasal delivery: a motion sickness medication."
5.	Pruritus (Itching) 04/01/1990 - "Promethazine appears to be the most effective in the prevention of chloroquine-induced pruritus but the differences were not significant. " 01/01/2010 - "Oral promethazine improved itching (P < 0.0058) and clinical scores (P < 0.032) significantly more than topical steroids. " 12/01/2004 - "However, the relationship between parasite density and resultant pruritus was significantly different between naltrexone and promethazine. " 12/01/2004 - "One patient on naltrexone and two on promethazine never experienced any itching. " 12/01/2004 - "Both naltrexone and promethazine subjectively reduced itching severity compared with prior historical experience. "

Related Drugs and Biologics

1.	Ondansetron (Zofran)
2.	Chlorpromazine (Thorazine)
3.	Chloroquine (Aralen)
4.	Meperidine (Pethidine)
5.	Promethazine (Promet)
6.	Dexamethasone (Maxidex)
7.	Midazolam (Versed)
8.	Caffeine (No Doz)
9.	Metoclopramide (Reglan)
10.	Lorazepam (Ativan)

Related Therapies and Procedures

1.	General Anesthesia
2.	Injections
3.	Drug Therapy (Chemotherapy)
4.	Sympathectomy (Sympathectomies)
5.	Analgesia