Promazine (Promazine Hydrochloride)

A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.

Also Known As:

Networked: 119 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Bodmer, Michael: 1 article (07/2015)
2.	Jick, Susan S: 1 article (07/2015)
3.	Rüegg, Stephan: 1 article (07/2015)
4.	Bloechliger, Marlene: 1 article (07/2015)
5.	Meier, Christoph R: 1 article (07/2015)
6.	Mehta, Hetal: 1 article (11/2011)
7.	Swinson, Nicola: 1 article (11/2011)
8.	Lewis, Glyn: 1 article (11/2011)
9.	Hiroeh, Urara: 1 article (11/2011)
10.	Skapinakis, Petros: 1 article (11/2011)

Related Diseases

1.	Body Weight (Weight, Body) 12/01/1985 - "Oral promazine proved to be a very effective and safe medication (average dosage in 57 patients without complications: 5.2 mg/kg body weight/90 minutes before CT-scanning; 96% successful sedation procedures) in comparison to 89 patients with i.m. " 12/01/1985 - "promazine (average dosage: 2.3 mg/kg body weight/45 min before CT with 92% adequate sedations but a complication rate of 7.9%). " 06/01/1983 - "Sleep was induced with 2 mg/kg body weight Protactyl syrus (promazie hydrochloride). " 01/01/1982 - "Animals refused to eat bait containing doses of promazine hydrochloride greater than 17 mg/kg body weight." 01/01/1982 - "Promazine hydrochloride at doses of 2 to 17 mg/kg body weight, given orally to wild pronghorn fawns and an adult, did not produce visible signs of tranquilization. "
2.	Schizophrenia (Dementia Praecox) 01/01/1960 - "The effect of promazine (spraine) on patients with chronic schizophrenia." 10/01/1959 - "Clinical evaluation of promazine therapy for schizophrenia." 01/01/1959 - "Effects of promazine hydrochloride on attention in chronic schizophrenia." 10/01/1957 - "Treatment of chronic schizophrenia with promazine hydrochloride." 01/01/1960 - "The effect of promazine (Sparine) on patients with chronic schizophrenia."
3.	Fibrosis (Cirrhosis) 01/01/1995 - "A newly developed galactose single point (GSP) method was applied to quantitatively measure the residual liver function in cirrhosis patients and successfully correlated it with promazine elimination half-life (r = 0.770, p < 0.01), total plasma clearance of free drug (r = 0.899, p < 0.005), metabolic clearance of free drug (r = 0.902, p < 0.005), and plasma protein binding (r = 0.822, p < 0.005). "
4.	Bipolar Disorder (Mania) 01/01/2008 - "Efforts to modify phenothiazines to find an antimalarial agent also failed but led to novel antiemetic-sedative antihistamines, including promethazine, promazine, and eventually chlorpromazine--the first effective treatment for schizophrenia and mania. "
5.	Poisoning 05/01/1969 - "[Acute poisoning with promazine. " 01/01/2003 - "We report the case of a young woman who - according to ECG, enzyme release, and echocardiography - developed transient acute myocardial ischemia and minimal myocardial damage following self-poisoning with promazine hydrochloride. " 08/01/2005 - "Relation of postmortem blood alcohol and drug concentrations in fatal poisonings involving amitriptyline, propoxyphene and promazine." 08/01/2005 - "In this study, we examined poisoning deaths involving amitriptyline, propoxyphene and promazine, which are, after benzodiazepines, the most frequently occurring drugs in Finnish alcohol-related poisonings. " 05/01/2003 - "The median postmortem blood alcohol concentration (BAC) was 3.3 percent per thousand (w/w) in the 615 alcohol poisonings, but significantly lower, ranging from 1.3 to 1.7 percent per thousand, when promazine, doxepin, amitriptyline or propoxyphene were found together with alcohol. "

Related Drugs and Biologics

1.	Chlorpromazine (Thorazine)
2.	Promethazine (Promet)
3.	Phenothiazines
4.	Histamine Antagonists (Antihistamines)
5.	Galactose (Galactopyranose)
6.	Carrier Proteins (Binding Protein)
7.	phenothiazine
8.	Triflupromazine
9.	Dextropropoxyphene (Darvon)
10.	Benzodiazepines

Related Therapies and Procedures

1.	Intravenous Injections
2.	Anesthesia
3.	Analgesia
4.	Oral Administration
5.	Adjuvant Chemotherapy