A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl-containing-peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.
Also Known As:
Prolyl Hydroxylase; Peptidyl Prolyl Hydroxylase; Procollagen Prolyl 4-Hydroxylase; Prolyl 4-Hydroxylase; 4-Dioxygenase, Proline,2-Oxoglutarate; 4-Hydroxylase, Procollagen Prolyl; 4-Hydroxylase, Prolyl; Dioxygenase, Procollagen-Proline; Hydroxylase, Peptidyl Prolyl; Hydroxylase, Proline; Hydroxylase, Prolyl; Hydroxylase, Protocollagen Prolyl; Procollagen Proline Dioxygenase; Procollagen Prolyl 4 Hydroxylase; Proline,2 Oxoglutarate 4 Dioxygenase; Prolyl 4 Hydroxylase; Prolyl 4-Hydroxylase, Procollagen; Prolyl Hydroxylase, Peptidyl; Prolyl Hydroxylase, Protocollagen; Proline Hydroxylase; Proline,2-Oxoglutarate 4-Dioxygenase; Protocollagen Prolyl Hydroxylase; Procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase