Progestins (Progestagens)

Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERONE. Primary actions of progestins, including natural and synthetic steroids, are on the UTERUS and the MAMMARY GLAND in preparation for and in maintenance of PREGNANCY.

Also Known As:

Networked: 2073 relevant articles (113 outcomes, 257 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Frye, Cheryl A: 19 articles (01/2011 - 01/2003)
2.	Hyder, Salman M: 15 articles (01/2013 - 02/2005)
3.	Seeger, H: 12 articles (07/2014 - 10/2000)
4.	Mueck, A O: 12 articles (07/2014 - 10/2000)
5.	Lanari, Claudia: 11 articles (01/2013 - 01/2002)
6.	Mueck, Alfred O: 10 articles (08/2011 - 07/2002)
7.	Lange, Carol A: 9 articles (04/2014 - 12/2004)
8.	Liang, Yayun: 9 articles (01/2013 - 02/2005)
9.	Seeger, Harald: 9 articles (08/2011 - 07/2002)
10.	Frye, C A: 8 articles (11/2013 - 08/2001)

Related Diseases

1.	Endometriosis (Adenomyosis) 08/01/2015 - "For over 50 years, oral progestins have been demonstrated to be effective in the treatment of endometriosis. " 12/01/2009 - "Oral progestins have been reported to be effective in the treatment of endometriosis. " 11/01/2014 - "Aim of the present review is to present the results of clinical studies on new trends of progestins in the treatment of endometriosis." 01/01/2011 - "To avoid the several subtle modalities for distorting facts and orientating opinions in favour of specific compounds, progestins and monophasic OC used continuously are here proposed as the reference comparator in all future randomized controlled trials on medical treatment for endometriosis." 12/01/2006 - "We performed a MEDLINE and EMBASE search to identify all studies published in the English language literature on the use of progestogens for the treatment of endometriosis. "
2.	Breast Neoplasms (Breast Cancer) 04/01/2011 - "The data presented are very important in terms of the positive results of progestogens and breast cancer risk in clinical studies so far." 12/01/1990 - "The progestins, another class of agonists, are also effective in the palliation of advanced breast cancer. " 01/01/1995 - "Whether progestins give protection against breast cancer is less clear. " 01/01/2013 - "This study confirms differential effects on breast cancer risk of progestagens and regimens specifically used in France. " 03/01/2012 - "In the present study we analyse its mechanism of regulation by progestins in breast cancer cells. "
3.	Neoplasms (Cancer) 12/01/2008 - "Taken together, these apparently disparate themes allowed me to suggest the idea that systemic progestins have the ability to reawaken cancers that were presumed to be either nonexistent or cured. " 01/29/1977 - "[Efficacy of progestagens in cancer of the corpus uteri]." 12/01/2013 - "This study suggests a protective effect of progestins against ovarian and oviductal cancers. " 11/01/2003 - "To study the effect of progestagens and the two PR isotypes on tumor dissemination, in vitro and in vivo models should be applied. " 10/01/2003 - "This study aimed to identify pathways of cytoskeleton regulation responsive to progestins and to determine whether these are perturbed when PRA is overexpressed to the levels seen in cancers. "
4.	Endometrial Neoplasms (Endometrial Cancer) 12/01/2001 - "Premenopausal women--especially young women--with endometrial cancer stage I may be treated successfully with progestins alone as primary therapy to preserve their child-bearing potential. " 04/01/2008 - "Primary treatment with either oral or intra-uterine progestagens to preserve fertility in younger women with endometrial carcinoma is effective in about 70% of cases. " 06/01/2001 - "The concept that hormonal therapy may be useful in the treatment of endometrial cancer antedated the pharmaceutical availability of progestational compounds. " 12/01/1999 - "Does it really offer as much protection against endometrial cancer as oral progestogens do?" 09/01/1979 - "Reduced incidence of endometrial cancer among postmenopausal women treated with progestogens."
5.	Endometrial Hyperplasia 01/01/2011 - "Comparison of the efficacy of three progestins in the treatment of simple endometrial hyperplasia without atypia." 01/01/2004 - "The addition of progestogens, either in continuous combined or sequential regimens, helped to reduce the risk of endometrial hyperplasia and improved adherence to therapy. " 01/01/2000 - "The addition of progestogens, either in continuous combined or sequential regimens, helped to prevent the development of endometrial hyperplasia and improved adherence to therapy (odds ratios of 3.7 for sequential therapy and 6.0 for continuous therapy). " 10/01/2011 - "We carried out a web-based survey of all UK consultant gynaecologists, from the Royal College of Obstetricians and Gynaecologists (RCOG) database, to evaluate the current practice and to enquire whether a trial between oral progestogens and LNG-IUS for endometrial hyperplasia is required. " 06/01/2001 - "By 1959, initial studies demonstrated the ability of progestins to reverse endometrial hyperplasias. "

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Hormones
3.	Gonadotropin-Releasing Hormone (GnRH)
4.	Progesterone
5.	Oral Contraceptives
6.	Levonorgestrel (Plan B)
7.	Tamoxifen
8.	Megestrol Acetate (Borea)
9.	Medroxyprogesterone Acetate (Depo-Provera)
10.	Danazol (Azol)

Related Therapies and Procedures

1.	Contraception (Birth Control)
2.	Hysterectomy
3.	Estrogen Replacement Therapy
4.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
5.	Injections