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Progeria (Hutchinson Gilford Syndrome)

An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature graying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
Also Known As:
Hutchinson Gilford Syndrome; Hutchinson Gilford Progeria Syndrome; Hutchinson-Gilford Progeria Syndrome; Hutchinson-Gilford Progeria Syndromes; Progeria Syndrome, Hutchinson-Gilford; Progeria Syndromes, Hutchinson-Gilford; Hutchinson-Gilford Syndrome
Networked: 747 relevant articles (21 outcomes, 37 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Progeria (Hutchinson Gilford Syndrome)
2. Inborn Genetic Diseases (Disease, Hereditary)
3. Lipodystrophy
4. Emery-Dreifuss Muscular Dystrophy (Scapuloperoneal Muscular Dystrophy)
5. Cardiomyopathies (Cardiomyopathy)

Experts

1. Young, Stephen G: 36 articles (01/2021 - 07/2004)
2. Fong, Loren G: 33 articles (01/2021 - 12/2004)
3. Yang, Shao H: 21 articles (04/2016 - 12/2004)
4. Gordon, Leslie B: 20 articles (06/2022 - 05/2003)
5. Andrés, Vicente: 19 articles (10/2022 - 10/2011)
6. Cao, Kan: 19 articles (01/2021 - 03/2007)
7. López-Otín, Carlos: 19 articles (01/2019 - 12/2005)
8. Misteli, Tom: 17 articles (07/2021 - 04/2005)
9. Eriksson, Maria: 16 articles (01/2022 - 05/2003)
10. Bergo, Martin O: 15 articles (10/2022 - 07/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Progeria:
1. Lamin Type A (Lamin A)IBA
2. prelamin AIBA
3. Peptides (Polypeptides)IBA
4. p21(ras) farnesyl-protein transferase (protein farnesyltransferase)IBA
5. EnzymesIBA
6. LaminsIBA
7. Adenosine Triphosphate (ATP)IBA
8. 1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
9. QuercetinIBA
10. fisetinIBA

Therapies and Procedures

1. Therapeutics
2. Cell- and Tissue-Based Therapy (Cell Therapy)
3. Conservative Treatment
4. Rejuvenation
5. Transplantation