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Pro-Opiomelanocortin (Proopiomelanocortin)

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A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).

Also Known As:

Proopiomelanocortin; POMC; ACTH-Endorphin Precursor; ACTH-beta-Lipotropin Precursor; Corticotropin-beta-Lipotropin Precursor; Endorphin-ACTH Precursor; Opiocortin; Pre-POMC; Pre-pro-opiocortin; Preproopiomelanocortin; Pro-ACTH-Endorphin; Pro-Opio-Melanocortin; Proopiocortin; ACTH Endorphin Precursor; ACTH beta Lipotropin Precursor; Corticotropin beta Lipotropin Precursor; Endorphin ACTH Precursor; Pre POMC; Pre pro opiocortin; Pro ACTH Endorphin; Pro Opio Melanocortin; Pro Opiocortin; Pro Opiomelanocortin; Pro-Opiocortin; Opiomelanocortin, pro-

Networked: 1235 relevant articles (28 outcomes, 154 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Low, Malcolm J: 17 articles (04/2015 - 06/2003)
2.	Elmquist, Joel K: 15 articles (06/2015 - 08/2002)
3.	Cowley, Michael A: 14 articles (01/2015 - 06/2003)
4.	Lowell, Bradford B: 13 articles (06/2015 - 06/2004)
5.	O'Rahilly, Stephen: 12 articles (05/2011 - 08/2002)
6.	White, Anne: 10 articles (09/2015 - 08/2002)
7.	Nillni, Eduardo A: 9 articles (04/2015 - 04/2004)
8.	Horvath, Tamas L: 9 articles (09/2014 - 03/2004)
9.	Tai, Ming-Hong: 9 articles (06/2014 - 02/2006)
10.	Coppari, Roberto: 9 articles (03/2012 - 06/2004)

Related Diseases

1.	Obesity 04/01/2011 - "The present study, for the first time, investigated the long-term efficacy of POMC gene transfer concurrently into both sites in the regulation of energy metabolism in aged F344xBN rats bearing adult-onset obesity. " 08/01/2011 - "POMC overexpression in the ventral tegmental area ameliorates dietary obesity." 09/15/2010 - "Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity." 11/01/2005 - "We assessed whether overproduction of POMC in the hypothalamus ameliorates age-related obesity in rats. " 02/01/2015 - "Preventing Obesity in the Military Community (POMC): the development of a clinical trials research network."
2.	AIDS-Related Complex (ARC) 01/01/2015 - "In this study, we used the modified rabies virus to map the brain areas that provide direct inputs to the POMC neurons in the ARC and NTS as well as the inputs to the ARC AgRP neurons for comparison. " 11/28/2014 - "This study aimed to determine whether Oxt regulates propiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus. " 11/17/2014 - "In vivo studies showed that SGA newborns and adult offspring had increased protein expression of hypothalamic/ARC SIRT1 and AgRP with decreased POMC. " 02/20/2013 - "Using pharmacogenetic methods to activate or deplete neuron groups in separate brain areas, in the present study, we show that POMC neurons in the ARC and NTS suppress feeding behavior at different time scales. " 08/01/2011 - "In this study, we compared the effects of delivery of a recombinant adeno-associated viral (rAAV) construct encoding POMC to the ARC with delivery to the ventral tegmental area (VTA). "
3.	Body Weight (Weight, Body) 06/01/2009 - "Here, we show that expression of ObRb only in POMC neurons leads to a marked decrease in energy intake and a modest reduction in body weight in Lepr(db/db) mice. " 09/01/2013 - "In conclusion, the exon 3 of gene POMC was associated with growth traits, and C allele was beneficial to the increase of body weight and body size traits of sheep, which potentially afford a good foundation for further study on POMC gene as aided breeding markers for growth traits in sheep." 08/01/2007 - "The study of POMC biology has lead to some fundamental insights into the mechanisms controlling food intake and body weight. " 06/01/2005 - "Associations of BMI, weight and total fat with SNPs in regions flanking the POMC gene in this powerful study suggest that regulation of POMC expression may be influential in determining body weight." 01/01/2001 - "This review will focus on the role of central melanocortin signaling in eating behavior and will evaluate studies of the neural pathways of POMC and AGRP systems, the effects of the central melanocortinergic system on food intake and body weight, and the regulation of hypothalamic POMC and AGRP neurons in response to altered feeding state and energy balance. "
4.	Neoplasms (Cancer) 10/01/2014 - "Expanding upon previous observations of high POMC in EAS, this study specifically demonstrates elevated POMC levels can identify occult ectopic tumors. " 04/22/1999 - "Further studies are required to elucidate the role of E2F factors in POMC gene transcription in SCLC cells, but our results have identified mechanisms different from those in pituitary corticotroph cells that are used by these SCLC tumor cells." 02/01/2016 - "In contrast, mutated tumors expressed significantly higher levels of POMC, SSTR5, and MGMT. " 01/01/2012 - "These results support the existence of an MC-1R-independent pathway for POMC gene therapy, which further expands the therapeutic spectrum of POMC therapy for multiple types of cancer." 01/01/2012 - "Lastly, POMC gene delivery induced a significant suppression of tumor vasculature. "
5.	Pain (Aches) 10/01/2009 - "This suggested that transfer of POMC by RSW is an effective treatment for inflammatory pain." 03/01/2010 - "Significant associations between the maximum number of pain sites and SNPs in the CRHBP and POMC genes were also observed and a SNP in MC2R was also associated with CWP. " 01/01/2009 - "Although MIDGE vectors circumvent side-effects associated with classical viral and plasmid vectors, the current POMC-MIDGE-NLS did not result in reliable analgesic effectiveness in our pain model. " 12/01/2005 - "Purulent fluids contained numerous bacteria of various types, thus suggesting that oral bacteria may cause symptoms such as pain in POMC with purulent fluids. " 06/01/2004 - "We previously reported that intrathecal pro-opiomelanocortin gene electroporation could reduce pain sensitivity induced by chronic constriction injury (CCI) of the sciatic nerve. "

Related Drugs and Biologics

1.	Pro-Opiomelanocortin (Proopiomelanocortin)
2.	Messenger RNA (mRNA)
3.	Leptin
4.	Insulin (Novolin)
5.	Hormones
6.	Glucose (Dextrose)
7.	Peptides
8.	beta-Endorphin (Endorphin, beta)
9.	Neuropeptide Y
10.	Leptin Receptors

Related Therapies and Procedures

1.	Thymectomy
2.	Tourniquets
3.	Intranasal Administration
4.	Analgesia
5.	Surgical Instruments (Clip)